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Interaction of Tobacco Smoking and Chewing with Angiotensin Converting Enzyme (Insertion/Deletion) Gene Polymorphisms and Risk of Lung Cancer in a High Risk Area from Northeast India

  • Phukan, Rup Kumar ;
  • Borah, Prasanta Kumar ;
  • Saikia, Bhaskar Jyoti ;
  • Das, Mandakini ;
  • Sekhon, Gaganpreet Singh ;
  • Mahanta, Jagadish
  • Published : 2015.01.22

Abstract

Background: Association of angiotensin converting enzyme (ACE) gene polymorphisms with lung cancer susceptibility remains uncertain and varies with ethnicity. Northeast India represents a geographically, culturally, and ethnically isolated population. The area reports an especially high rate of tobacco usage in a variety of ways of consumption, compared with the rest of the Indian population. Materials and Methods: We conducted a population based case control study in two major high risk region for lung cancer from Northeast India. A total of 151 consecutive lung cancer cases diagnosed histopathologically and equal numbers of controls were recruited with record of relevant sociodemographic information. Blood samples were collected and processed to identify ACE gene polymorphism. Results: Significantly higher (40.4 % vs 29.1%, OR=1.97, CI=1.04-3.72; p=0.037) prevalence of the ACE II genotype was observed among lung cancer cases. Smoking was significantly associated with increased risk of lung cancer (OR=1.70, CI=1.02-2.81; p=0.041). An enhanced risk was also observed for interaction of ACE II genotype with tobacco smoking (OR=4.09, CI=1.51-11.05; p=0.005) and chewing (OR=3.68, CI=1.22-11.13; p=0.021). Conclusions: The present study indicates significant association s of the ACE II genotype with lung cancer in high risk Northeast India.

Keywords

Angiotensin converting enzyme;bradykinin;lung cancer;polymorphisms

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Cited by

  1. gene polymorphisms and plasma nitric oxide with risk of non-small cell lung cancer in South India pp.17526981, 2016, https://doi.org/10.1111/crj.12517
  2. Cost-effectiveness of lung cancer screening and treatment methods: a systematic review of systematic reviews vol.17, pp.1, 2017, https://doi.org/10.1186/s12913-017-2374-1
  3. Risk of major cancers associated with various forms of tobacco use in India: a systematic review and meta-analysis pp.1613-2238, 2018, https://doi.org/10.1007/s10389-018-0992-7

Acknowledgement

Supported by : Indian Council of Medical Research