- Volume 15 Issue 23
DOI QR Code
Protective Effect of Astragalus polysaccharides on Liver Injury Induced by Several Different Chemotherapeutics in Mice
- Liu, Wen (Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University) ;
- Gao, Fang-Fang (Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University) ;
- Li, Qun (Renmin Hospital of Wuhan University, the First College of Clinical Medicine of Wuhan University) ;
- Lv, Jia-Wei (Zhongnan Hospital of Wuhan University, the Second College of Clinical Medicine of Wuhan University) ;
- Wang, Ying (Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University) ;
- Hu, Peng-Chao (Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University) ;
- Xiang, Qing-Ming (Zhongnan Hospital of Wuhan University, the Second College of Clinical Medicine of Wuhan University) ;
- Wei, Lei (Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University)
- Published : 2015.01.06
Side effects are an unavoidable consequence of chemotherapy drugs, during which liver injury often takes place. The current study was designed to investigate the protective effect of Astragalus polysaccharides (APS) against the hepatotoxicity induced by frequently-used chemical therapy agents, cyclophosphamide (CTX), docetaxel (DTX) and epirubicin (EPI)) in mice. Mice were divided into five groups, controls, low or high dose groups (
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