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The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer

  • Kafshdooz, Leila (Women's Reproductive Health Research Center, Department of Medical Genetics, Tabriz University of Medical Sciences) ;
  • Tabrizi, Ali Dastranj (Women's Reproductive Health Research Center, Department of Medical Genetics, Tabriz University of Medical Sciences) ;
  • Mohaddes, Seyyed Mojtaba (Faculty of Medicine, Tabriz University of Medical Sciences) ;
  • Kafshdooz, Tayebeh (Women's Reproductive Health Research Center, Department of Medical Genetics, Tabriz University of Medical Sciences) ;
  • Akbarzadeh, Abolfazl (Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University Of Medical Sciences) ;
  • Ghojazadeh, Morteza (Women's Reproductive Health Research Center, Department of Medical Genetics, Tabriz University of Medical Sciences) ;
  • Gharesouran, Jalal (Faculty of Medicine, Tabriz University of Medical Sciences)
  • Published : 2015.01.06

Abstract

Background: Endometral carcinoma is the most common malignant tumor of the female genital tract and the fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important roles in the development and progression of cancer through activation of various genes that are involved in crucial aspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, and cell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms and endometrial cancer. Materials and Methods: 75 patients with endometrial carcinoma and 75 patients whose underwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphisms by PCR-RFLP and sequencing. Results: For the 1772 C/T polymorphism, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk. Conclusions: Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.

Keywords

Endometrial carcinoma;HIF-1a polymorphism

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