XELOX Plus Bevacizumab vs. FOLFIRI Plus Bevacizumab Treatment for First-line Chemotherapy in Metastatic Colon Cancer: a Retrospective Study of the Anatolian Society of Medical Oncology

  • Duran, Ayse Ocak (Department of Medical Oncology, Erciyes University) ;
  • Karaca, Halit (Department of Medical Oncology, Erciyes University) ;
  • Besiroglu, Mehmet (Department of Medical Oncology, Marmara University) ;
  • Bayoglu, Ibrahim Vedat (Department of Medical Oncology, Izmir Katip Celebi University, Ataturk Training and Research Hospital) ;
  • Menekse, Serkan (Department of Medical Oncology, Celal Bayar University) ;
  • Yapici, Heves Surmeli (Department of Medical Oncology, Kartal Training and Research Hospital) ;
  • Yazilitas, Dogan (Department of Medical Oncology, Konya Training and Research Hospital) ;
  • Bahceci, Aykut (Department of Medical Oncology, Cumhuriyet University) ;
  • Uysal, Mukremin (Department of Medical Oncology, Afyon Kocatepe University) ;
  • Sevinc, Alper (Department of Medical Oncology, Gaziantep University) ;
  • Hacibekiroglu, Ilhan (Department of Medical Oncology, Trakya University) ;
  • Aksoy, Asude (Department of Medical Oncology, Firat University) ;
  • Tanriverdi, Ozgur (Department of Medical Oncology, Mugla University) ;
  • Arpaci, Erkan (Department of Medical Oncology, Sakarya Training and Research Hospital) ;
  • Inanc, Mevlude (Department of Medical Oncology, Kayseri Education and Research Hospital) ;
  • Dane, Faysal (Department of Medical Oncology, Marmara University) ;
  • Ozkan, Metin (Department of Medical Oncology, Erciyes University)
  • Published : 2015.01.06


Background: XELOX plus bevacizumab (XELOX-Bev) and FOLFIRI plus Bevacizumab (FOLFIRI - Bev) treatments are an effective strategies patients with metastatic colorectal cancer (mCRC).The aim of this study was to compare efficacy of first-line XELOX-Bev treatment vs FOLFIRI-Bev treatment for mCRC. Materials and Methods: A total of 409 patients with mCRC who received chemotherapy were included and divided into 2 groups. Group 1 (n=298) received XELOX-Bev and Group 2 (n=111) FOLFIRI-Bev. Comparisons were made in terms of overall (OS) and progression-free (PFS) survival, response rate (RR), and grade 3-4 toxicity. Results: Median follow-up was 11 months in Group 1 and 15 months for Group 2. Complete remission was observed in 29 (9.7%) and 2 (1.8%) patients, partial remission in 139 (46.6%) and 27 (24.5%), stable disease in 88 (29.5%) and 49 (44.1%) and progressive disease in 42 (14.1%) and 33 (30.0%) patients in Group 1 and 2, respectively. Median OS was 25 months (range 2-57 months, 95%CI; 22.2-27.7) for Group 1 and 20 months (range 1-67 months, 95%CI; 16.8-23.1) for Group 2 (p=0.036). Median PFS was 9.6 months (range 2-36 months, 95%CI; 8.8-10.4) for Group 1 and 9 months (range 1-44 months, 95%CI; 7.4-10.5) for Group 2 (p=0.019). Objective RR was 56.4% in Group 1 and 26.1% in Group 2 (p<0.001). Conclusions: First-line XELOX-Bev is more effective with a better response rate, prolongation of median PFS/OS, and a superior safety profile compared with FOLFIRI-Bev.


Metastatic colorectal cancer;XELOX plus bevacizumab;FOLFIRI plus bevacizumab;comparison


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