DOI QR코드

DOI QR Code

Clinicopathological Findings and Five Year Survival Rates for Patients with Central Nervous System Tumors in Yazd, Iran

  • Zahir, Shokouh Taghipour (Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences) ;
  • Vakili, Mahmood (Department of Community Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences) ;
  • Navabii, Hossein (School of Medicine, Shahid Sadoughi University of Medical Sciences) ;
  • Rahmani, Koorosh (School of Medicine, Shahid Sadoughi University of Medical Sciences)
  • Published : 2015.01.06

Abstract

Background: The incidence rate of brain tumors has increased more than 40% in the past 20 years, especially in adults. We aimed to study the clinical and pathological findings of central nervous system (CNS) tumor patients and to evaluate their 5 year survival rates. Materials and Methods: The archives of all patients with CNS tumors in 6 health care centers in Yazd, Iran, from 2006 to 2013, were studied. Patients data were extracted using a checklist which included age, sex, date of reference and diagnosis, date of death, clinical signs, radiography findings, pathology report, size and location of tumor, patient treatment and grade of tumor. Results: A total of 306 patient records were studied in the 8 year period. The most prevalent type of tumor was astrocytoma (n=113, 36.9%). The frequency of almost all tumor types was statistically higher in male patients (p=0.025). In most cases surgery with radiotherapy was the treatment of choice (49.3%). The most frequent symptom reported was headache (in 60.8% of patients) followed by convulsions (15.7%). Most of the tumors were located in the right hemisphere (46.1%) and the frontal and parietal lobe (26% and 12%, respectively). Radiography findings displayed edema with a nonhomogeneous lesion in majority of the patients (87%). The survival fraction of the patients with malignant tumors decreased over time (0.807 in the first year and 0.358 at the end of the $5^{th}$ year). Conclusions: Astrocytoma was the more common CNS tumor with male predominance. Overall survival rates of malignant tumors decreased over time and this was in relation with tumor grade.

Keywords

Survival;central nervous system;neoplasm;brain;histopathology

References

  1. Thakkar JP, McCarthy BJ, Villano JL (2014). Age-specific cancer incidence rates increase through the oldest age groups. Am J Med Sci, 348, 65-70. https://doi.org/10.1097/MAJ.0000000000000281
  2. Parkin DM (2001). Global cancer statistics in the year 2000. Lancet Oncol, 2, 533-43. https://doi.org/10.1016/S1470-2045(01)00486-7
  3. Jemal A, Siegel R, Xu J, Ward E (2010). Cancer statistics, 2010. CA Cancer J Clin, 60, 277-300. https://doi.org/10.3322/caac.20073
  4. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  5. Omar S, Alieldin NH, Khatib OM (2007). Cancer magnitude, challenges and control in the Eastern Mediterranean region. East Mediterr Health J, 13, 1486-96.
  6. Mehta M, Vogelbaum MA, Chang S, et al (2011). Neoplasms of the central nervous system. In: DeVita VT Jr, Lawrence TS, Rosenberg SA: Cancer: Principles and Practice of Oncology. 9th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 1700-49.
  7. Yilmaz U, Zeybek U, Kahraman OT, et al (2013). Investigation of ICAM-1 and ${\beta}$3 integrin gene variations in patients with brain tumors. Asian Pac J Cancer Prev,14, 5929-34. https://doi.org/10.7314/APJCP.2013.14.10.5929
  8. Sayegh ET, Aranda D, Kim JM, et al (2014). Prognosis by tumor location in adults with intracranial ependymomas. J Clin Neurosci, 21, 2096-101. https://doi.org/10.1016/j.jocn.2014.05.011
  9. Louis DN, Ohgaki H, Wiestler OD, et al (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol, 114, 97-109. https://doi.org/10.1007/s00401-007-0243-4
  10. Zhang CP, Li HQ, Zhang WT, et al (2014). Clinical manifestations and imaging characteristics of gliomatosis cerebri with pathological confirmation. Asian Pac J Cancer Prev, 15, 4487-91. https://doi.org/10.7314/APJCP.2014.15.11.4487
  11. Mao Y, Desmeules M, Semenciw RM, et al (1991). Increasing brain cancer rates in Canada. CMAJ, 145,1583-91.
  12. Jazayeri SB, Rahimi-Movaghar V, Shokraneh F, et al (2013). Epidemiology of primary CNS tumors in Iran: a systematic review. Asian Pac J Cancer Prev, 14, 3979-85. https://doi.org/10.7314/APJCP.2013.14.6.3979
  13. Porter KR, McCarthy BJ, Freels S, et al (2010). Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology. Neuro Oncol, 12, 520-7. https://doi.org/10.1093/neuonc/nop066
  14. Jiang T, Tang GF, Lin Y, et al (2011). Prevalence estimates for primary brain tumors in China: a multi-center cross-sectional study. Chin Med J, 124, 2578-83.
  15. Gabriella M. Anic, Melissa H. Madden, L. Burton Nabors, et al (2014). Reproductive factors and risk of primary brain tumors in women. J Neurooncol, 118, 297-304. https://doi.org/10.1007/s11060-014-1427-0
  16. Sun T, Warrington NM, Luo J, et al (2014).Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males. The Journal of Clinical Investigation, online, Aug. 1, www.sciencedaily.com/releases/2014/08/140801213341.html.
  17. SEER Stat Fact Sheets: Brain and Other Nervous System Cancer (2014). Available from: http://seer.cancer.gov/csr/1975_2011/results_merged/sect_03_brain_ons.pdf.
  18. Kohler BA, Ward E, McCarthy BJ, et al)2011(.Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst, 103, 714-36. https://doi.org/10.1093/jnci/djr077
  19. Ahmed N, Bhurgri Y, Sadiq S, et al (2007).Pediatric brain tumours at a tertiary care hospital in Karachi. Asian Pac J Cancer Prev, 8, 399-404.
  20. Mehrazin M, Yavari P (2007). Morphological pattern and frequency of intracranial tumors in children. Childs Nerv Syst, 23, 157-62. https://doi.org/10.1007/s00381-006-0198-0
  21. Makino K, Nakamura H, Yano S, et al (2010). Population-based epidemiological study of primary intracranial tumors in childhood. Childs Nerv Syst, 26, 1029-34. https://doi.org/10.1007/s00381-010-1126-x
  22. Asirvatham JR, Deepti AN, Chyne R, et al (2011). Pediatric tumors of the central nervous system: a retrospective study of 1,043 cases from a tertiary care center in South India. Childs Nerv Syst, 27, 1257-63. https://doi.org/10.1007/s00381-011-1407-z
  23. Bock HC, Puchner MJ, Lohmann F, et al (2010). First-line treatment of malignant glioma with carmustine implants followed by concomitant radio chemotherapy: a multicenter experience. Neurosurg Rev, 33, 441-9. https://doi.org/10.1007/s10143-010-0280-7
  24. Brain tumor symptoms. Cancer Research UK (2013) Available from: http://www.cancerresearchuk.org/cancer-help/type/brain-tumour/about/brain-tumour-symptoms#common.
  25. Pashaki AS, Akbari-Hamed E, Mohamadian K, et al (2014). Efficacy of high dose radiotherapy in post-operative treatment of glioblastoma multiform - a single institution report. Asian Pac J Cancer Prev, 15, 2793-6. https://doi.org/10.7314/APJCP.2014.15.6.2793
  26. Manoharan N, Julka PK, Rath GK (2012). Descriptive epidemiology of primary brain and CNS tumors in Delhi, 2003-2007. Asian Pac J Cancer Prev, 13, 637-40. https://doi.org/10.7314/APJCP.2012.13.2.637
  27. Fuentes-Raspall R, Vilardell L, Perez-Bueno F, et al (2011). Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994-2005. J Neurooncol, 101, 117-23. https://doi.org/10.1007/s11060-010-0240-7

Cited by

  1. Comprehensive analysis of Iranian reports of pediatric central nervous system tumors vol.33, pp.9, 2017, https://doi.org/10.1007/s00381-017-3468-0