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No Effect of Energy Intake Overall on Risk of Endometrial Cancers: a Meta-analysis

  • Chu, Ke-Tan (Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine) ;
  • Song, Yang (Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine) ;
  • Zhou, Jian-Hong (Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine)
  • Published : 2015.01.06

Abstract

Background: Previous epidemiologic studies on the association between energy intake and endometrial cancer risk have only generated contradictory results. The role of energy intake in endometrial carcinogenesis thus remains unclear. To quantitatively assess the potential association between energy intake and endometrial cancer, a meta-analysis of case-control and cohort studies was here conducted. Materials and Methods: Eligible studies were retrieved via both computerized searches and review of references. Fixed-or random-effect models were used to summarize the estimates of OR with 95%CIs. Stratified analyses on study design, region and macronutrients' calorie were performed. Results: Sixteen studies met the inclusion criteria of the meta-analysis. No association between total energy intake and endometrial cancer was observed in either overall group (OR=1.11, 95%CI 0.92-1.30) or subgroups stratified by study design and region. In the specific macronutrients' calorie analysis, higher fat energy intake was found to be associated with increased endometrial risk (OR=1.72, 95%CI 1.12-2.32) while energy from carbohydrate and protein was not related to endometrial cancer risk. Conclusions: Our analysis did not support that total energy intake is related to endometrial cancer risk, in contrast to fat energy.

Keywords

Endometrial cancer;energy;meta-analysis;overall intake;fat intake

References

  1. Acmaz G, Aksoy H, Albayrak E, et al (2014). Evaluation of endometrial precancerous lesions in postmenopausal obese women-a high risk group? Asian Pac J Cancer Prev, 15, 195-8. https://doi.org/10.7314/APJCP.2014.15.1.195
  2. Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML (2007). Fruits and vegetables and endometrial cancer risk: a systematic literature review and meta-analysis. Nutr Cancer, 58, 6-21. https://doi.org/10.1080/01635580701307929
  3. Barbosa JC, Shultz TD, Filley SJ, Nieman DC (1990). The relationship among adiposity, diet, and hormone concentrations in vegetarian and nonvegetarian postmenopausal women. Am J Clin Nutr, 51, 798-803.
  4. Biel RK, Csizmadi I, Cook LS, et al. (2011a). Risk of endometrial cancer in relation to individual nutrients from diet and supplements. Public Health Nutr, 14, 1948-60. https://doi.org/10.1017/S1368980011001066
  5. Biel RK, Friedenreich CM, Csizmadi I, et al (2011b). Casecontrol study of dietary patterns and endometrial cancer risk. Nutr Cancer, 63, 673-86. https://doi.org/10.1080/01635581.2011.563025
  6. Bjorge T, Engeland A, Tretli S, Weiderpass E (2007). Body size in relation to cancer of the uterine corpus in 1 million Norwegian women. Int J Cancer, 120, 378-83. https://doi.org/10.1002/ijc.22260
  7. Bravi F, Scotti L, Bosetti C, et al (2009). Food groups and endometrial cancer risk: a case-control study from Italy. Am J Obstet Gynecol, 200, 1-7. https://doi.org/10.1016/j.ajog.2008.09.007
  8. Bruning PF, Bonfrer JM (1986). Free fatty acid concentrations correlated with the available fraction of estradiol in human plasma. Cancer Res, 46, 2606-9.
  9. Cui X, Rosner B, Willett WC, Hankinson SE (2011). Dietary fat, fiber, and carbohydrate intake in relation to risk of endometrial cancer. Cancer Epidemiol Biomarkers Prev, 20, 978-89. https://doi.org/10.1158/1055-9965.EPI-10-1089
  10. Cust AE, Slimani N, Kaaks R, et al (2007). Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort. Am J Epidemiol, 166, 912-23. https://doi.org/10.1093/aje/kwm161
  11. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  12. Duval S, Tweedie R (2000). Trim and fill: A simple funnel-plotbased method of testing and adjusting for publication bias in meta-analysis. Biometrics, 56, 455-63. https://doi.org/10.1111/j.0006-341X.2000.00455.x
  13. Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  14. Folsom AR, Demissie Z, Harnack L (2003). Glycemic index, glycemic load, and incidence of endometrial cancer: the Iowa women's health study. Nutr Cancer, 46, 119-24. https://doi.org/10.1207/S15327914NC4602_03
  15. Friedenreich C, Cust A, Lahmann PH, et al (2007). Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition. Cancer Causes Control, 18, 399-413. https://doi.org/10.1007/s10552-006-0113-8
  16. Furberg AS, Thune I (2003). Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. Int J Cancer, 104, 669-76. https://doi.org/10.1002/ijc.10974
  17. Goldin BR, Adlercreutz H, Gorbach SL, et al (1982). Estrogen excretion patterns and plasma levels in vegetarian and omnivorous women. N Engl J Med, 307,1542-7. https://doi.org/10.1056/NEJM198212163072502
  18. Goodman MT, Wilkens LR, Hankin JH, et al (1997). Association of soy and fiber consumption with the risk of endometrial cancer. Am J Epidemiol, 146, 294-306. https://doi.org/10.1093/oxfordjournals.aje.a009270
  19. Hsieh LJ, Carter HB, Landis PK, et al (2003). Association of energy intake with prostate cancer in a long-term aging study: baltimore longitudinal study of aging (United States). Urology, 61, 297-301. https://doi.org/10.1016/S0090-4295(02)02120-9
  20. Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC (2003). Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med, 54, 131-52. https://doi.org/10.1146/annurev.med.54.101601.152156
  21. Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN (2010). Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis, 31, 83-9. https://doi.org/10.1093/carcin/bgp280
  22. Jain MG, Rohan TE, Howe GR, Miller AB (2000). A cohort study of nutritional factors and endometrial cancer. Eur J Epidemiol, 16, 899-905. https://doi.org/10.1023/A:1011012621990
  23. Jamison PM, Noone AM, Ries LA, Lee NC, Edwards BK (2013). Trends in endometrial cancer incidence by race and histology with a correction for the prevalence of hysterectomy, SEER 1992 to 2008. Cancer Epidemiol Biomarkers Prev, 22, 233-41. https://doi.org/10.1158/1055-9965.EPI-12-0996
  24. Jiang W, Zhu Z, Bhatia N, Agarwal R, Thompson HJ (2002). Mechanisms of energy restriction: effects of corticosterone on cell growth, cell cycle machinery, and apoptosis. Cancer Res, 62, 5280-7.
  25. Jiang W, Zhu Z, Thompson HJ (2003). Effect of energy restriction on cell cycle machinery in 1-methyl-1-nitrosourea-induced mammary carcinomas in rats. Cancer Res, 63, 1228-34.
  26. Kaaks R, Lukanova A, Kurzer MS (2002). Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev, 11, 1531-43.
  27. Klement RJ, Kammerer U (2011). Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutr Metab (Lond), 8,75. https://doi.org/10.1186/1743-7075-8-75
  28. Kritchevsky D (1999). Caloric restriction and experimental carcinogenesis. Toxicol Sci, 52, 13-6. https://doi.org/10.1093/toxsci/52.2.13
  29. Lau J, Ioannidis JP, Schmid CH (1997). Quantitative synthesis in systematic reviews. Ann Intern Med, 127, 820-6. https://doi.org/10.7326/0003-4819-127-9-199711010-00008
  30. Levi F, Franceschi S, Negri E, La Vecchia C (1993). Dietary factors and the risk of endometrial cancer. Cancer, 71, 3575-81. https://doi.org/10.1002/1097-0142(19930601)71:11<3575::AID-CNCR2820711119>3.0.CO;2-0
  31. Littman AJ, Beresford SA, White E (2001). The association of dietary fat and plant foods with endometrial cancer (United States). Cancer Causes Control, 12, 691-702. https://doi.org/10.1023/A:1011292003586
  32. Loft S, Velthuis-te Wierik EJ, van den Berg H, Poulsen HE (1995). Energy restriction and oxidative DNA damage in humans. Cancer Epidemiol Biomarkers Prev, 4, 515-9.
  33. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  34. McCann SE, Freudenheim JL, Marshall JR, et al (2000). Diet in the epidemiology of endometrial cancer in western New York (United States). Cancer Causes Control, 11, 965-74. https://doi.org/10.1023/A:1026551309873
  35. Nordeen SK, Bona BJ, Jones DN, Lambert JR, Jackson TA (2013). Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin. Horm Cancer, 4, 293-300. https://doi.org/10.1007/s12672-013-0150-1
  36. Petridou E, Kedikoglou S, Koukoulomatis P, Dessypris N, Trichopoulos D (2002). Diet in relation to endometrial cancer risk: a case-control study in Greece. Nutr Cancer, 44, 16-22. https://doi.org/10.1207/S15327914NC441_3
  37. Potischman N, Swanson CA, Brinton LA, et al (1993). Dietary associations in a case-control study of endometrial cancer. Cancer Causes Control, 4, 239-50.
  38. Shu XO, Zheng W, Potischman N, et al (1993). A populationbased case-control study of dietary factors and endometrial cancer in Shanghai, people's republic of China. Am J Epidemiol, 137, 155-65.
  39. Stoll BA (1999). New metabolic-endocrine risk markers in endometrial cancer. Br J Obstet Gynaecol, 106, 402-6. https://doi.org/10.1111/j.1471-0528.1999.tb08290.x
  40. Sue LY, Schairer C, Ma X, et al (2009). Energy intake and risk of postmenopausal breast cancer: an expanded analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Cancer Epidemiol Biomarkers Prev, 18, 2842-50. https://doi.org/10.1158/1055-9965.EPI-09-0087
  41. Sun Z, Liu L, Wang PP, et al (2012). Association of total energy intake and macronutrient consumption with colorectal cancer risk: results from a large population-based case-control study in Newfoundland and Labrador and Ontario, Canada. Nutr J, 11, 18. https://doi.org/10.1186/1475-2891-11-18
  42. Thompson HJ, Jiang W, Zhu Z (1999). Mechanisms by which energy restriction inhibits carcinogenesis. Adv Exp Med Biol, 470, 77-84. https://doi.org/10.1007/978-1-4615-4149-3_8
  43. Tinelli A, Vergara D, Martignago R, et al (2008). Hormonal carcinogenesis and socio-biological development factors in endometrial cancer: a clinical review. Acta Obstet Gynecol Scand, 87, 1101-13. https://doi.org/10.1080/00016340802160079
  44. Tretli S, Gaard M (1996). Lifestyle changes during adolescence and risk of breast cancer: an ecologic study of the effect of world war II in Norway. Cancer Causes Control, 7, 507-12. https://doi.org/10.1007/BF00051882
  45. Troisi R, Potischman N, Hoover RN, Siiteri P, Brinton LA (1997). Insulin and endometrial cancer. Am J Epidemiol, 146, 476-82. https://doi.org/10.1093/oxfordjournals.aje.a009301
  46. Tzonou A, Lipworth L, Kalandidi A, et al. (1996). Dietary factors and the risk of endometrial cancer: a case--control study in Greece. Br J Cancer, 73, 1284-90. https://doi.org/10.1038/bjc.1996.246
  47. Voskuil DW, Monninkhof EM, Elias SG, Vlems FA, van Leeuwen FE (2007). Physical activity and endometrial cancer risk, a systematic review of current evidence. Cancer Epidemiol Biomarkers Prev, 16, 639-48. https://doi.org/10.1158/1055-9965.EPI-06-0742
  48. Xu WH, Dai Q, Xiang YB, et al (2007). Nutritional factors in relation to endometrial cancer: a report from a populationbased case-control study in Shanghai, China. Int J Cancer, 120, 1776-81. https://doi.org/10.1002/ijc.22456
  49. Yeh M, Moysich KB, Jayaprakash V, et al (2009). Higher intakes of vegetables and vegetable-related nutrients are associated with lower endometrial cancer risks. J Nutr, 139, 317-22.
  50. Zhang Y, Liu H, Yang S, et al (2013). Overweight, obesity and endometrial cancer risk: results from a systematic review and meta-analysis. Int J Biol Markers, 29, 21-9.
  51. Zheng W, Kushi LH, Potter JD, et al (1995). Dietary intake of energy and animal foods and endometrial cancer incidence. The Iowa women's health study. Am J Epidemiol, 142, 388-94.
  52. Zhu Z, Jiang W, Thompson HJ (2003). Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas. Carcinogenesis, 24, 1225-31. https://doi.org/10.1093/carcin/bgg077

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