- Volume 15 Issue 23
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Risk of Treatment Related Death and Febrile Neutropaenia with First Line Palliative Chemotherapy for De Novo Metastatic Breast Cancer in Clinical Practice in a Middle Resource Country
- Phua, Chee Ee (Clinical Oncology Unit, Faculty of Medicine, University of Malaya) ;
- Tang, Weng Heng (Clinical Oncology Unit, Faculty of Medicine, University of Malaya) ;
- Yusof, Mastura Md. (Clinical Oncology Unit, Faculty of Medicine, University of Malaya) ;
- Saad, Marniza (Clinical Oncology Unit, Faculty of Medicine, University of Malaya) ;
- Alip, Adlinda (Clinical Oncology Unit, Faculty of Medicine, University of Malaya) ;
- See, Mee Hoong (Department of Surgery, Faculty of Medicine, University of Malaya) ;
- Taib, Nur Aishah (Department of Surgery, Faculty of Medicine, University of Malaya)
- Published : 2015.01.06
Background: The risk of febrile neutropaenia (FN) and treatment related death (TRD) with first line palliative chemotherapy for de novo metastatic breast cancer (MBC) remains unknown outside of a clinical trial setting despite its widespread usage. This study aimed to determine rates in a large cohort of patients treated in the University of Malaya Medical Centre (UMMC). Materials and Methods: Patients who were treated with first line palliative chemotherapy for de novo MBC from 2002-2011 in UMMC were identified from the UMMC Breast Cancer Registry. Information collected included patient demographics, histopathological features, treatment received, including the different chemotherapy regimens, and presence of FN and TRD. FN was defined as an oral temperature >
De novo metastatic breast cancer;palliative chemotherapy;febrile neutropaenia;treatment related death
Supported by : Ministry of Higher Education
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