- Volume 15 Issue 23
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Differences in the Prognostic Significance of the SUVmax between Patients with Resected Pulmonary Adenocarcinoma and Squamous Cell Carcinoma
- Motono, Nozomu (Department of Thoracic Surgery, Kanazawa Medical University) ;
- Ueno, Masakatsu (Department of Thoracic Surgery, Kanazawa Medical University) ;
- Tanaka, Makoto (Department of Thoracic Surgery, Kanazawa Medical University) ;
- Machida, Yuichiro (Department of Thoracic Surgery, Kanazawa Medical University) ;
- Usuda, Katsuo (Department of Thoracic Surgery, Kanazawa Medical University) ;
- Sakuma, Tsutomu (Department of Thoracic Surgery, Kanazawa Medical University) ;
- Sagawa, Motoyasu (Department of Thoracic Surgery, Kanazawa Medical University)
- Published : 2015.01.06
Background: The purpose of this study was to determine the prognostic significance of the maximum standardized uptake value (SUVmax) on F-18-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in patients undergoing surgical treatment for non-small cell lung cancer. Materials and Methods: Seventy-eight consecutive patients (58 with adenocarcinomas, 20 with squamous cell carcinomas) treated with potentially curative surgery were retrospectively reviewed. Results: The SUVmax was significantly higher in the patients with recurrent than with non-recurrent adenocarcinoma (p<0.01). However, among the patients with squamous cell carcinoma, there were no differences with or without recurrence (p=0.69). Multivariate analysis indicated that the SUVmax of adenocarcinoma lesions was a significant predictor of disease-free survival (p=0.04). In addition, an SUVmax of 6.19, the cut-off point based on ROC curve analysis of the patients with pathological IB or more advanced stage adenocarcinomas, was found to be a significant predictor of disease-free survival (p<0.01). Conclusions: SUVmax is a useful predictor of disease-free survival in patients with resected adenocarcinoma, but not squamous cell carcinoma. Patients with adenocarcinoma exhibiting an SUVmax above 6.19 are candidates for more intensive adjuvant therapy.
Non-small cell lung cancer;histologic type;PET;maximum standardized uptake value;prognosis
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