Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

  • Bai, Rong-Pan (Institute of Environmental Health, Zhejiang Univerisity School of Medicine) ;
  • Weng, Yu (Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang Univerisity School of Medicine) ;
  • Su, Li-Ling (Institute of Environmental Health, Zhejiang Univerisity School of Medicine) ;
  • Jin, Ming-Juan (Institute of Environmental Health, Zhejiang Univerisity School of Medicine) ;
  • Xu, Zheng-Ping (Institute of Environmental Health, Zhejiang Univerisity School of Medicine) ;
  • Lu, Li-Qin (Department of Oncology, Zhejiang Provincial People's Hospital) ;
  • Chen, Guang-Di (Institute of Environmental Health, Zhejiang Univerisity School of Medicine)
  • Published : 2015.01.06


MicroRNA-27a is highly expressed in cancers and has been identified as an oncogenic microRNA. A genetic variant in pre-miR-27a (rs895819) with a transition of A to G has been demonstrated to be associated with cancer risk; however, the results of these studies remain conflicting rather than conclusive. Therefore, we performed a meta-analysis to derive a more precise estimation. Through searching PubMed or other databases up to March 2014 using the following MeSH terms and keywords, "miR-27a", "polymorphism" and "cancer", seventeen case-control studies were identified in this meta-analysis, including 7,813 cases and 9,602. Crude odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to investigate the association strength between rs895819 and the susceptibility of cancer. The results of the overall meta-analysis did not suggest any association between rs895819 polymorphism and cancer susceptibility, and this remained in Asians as a subgroup. In Caucasians, however, the rs895819 was associated with a reduced cancer risk in heterozygous (OR, 0.83; 95%CI, 0.75-0.93) and dominant models (OR, 0.84; 95%CI, 0.76-0.93), and the [G] allele of rs895819 showed a protective effect (OR, 0.90, 95%CI, 0.84-0.97). Further studies showed a significant association between the [G] allele of rs895819 and decreased risk of breast cancer (0.91; 95%CI, 0.85-0.98), and stratified analyses indicated a protective effect of the [G] allele in Caucasians (OR, 0.89; 95%CI, 0.82-0.98), younger breast cancer cases (OR, 0.87; 95%CI, 0.79-0.96), and in the group of unilateral breast cancer patients (OR, 0.90; 95%CI, 0.83-0.97). These findings suggest an association between pre-miR-27a polymorphism rs895819 and cancer risk in Caucasians. The protective effect of rs895819 [G] allele in younger breast cancer and in the group of unilateral breast cancer patients await further confirmation since the included studies in this meta-analysis were limited.


Supported by : National Natural Science Foundation of China


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