Effects of a lipid-encapsulated zinc oxide dietary supplement, on growth parameters and intestinal morphology in weanling pigs artificially infected with enterotoxigenic Escherichia coli

  • Kim, Sung jae (College of Veterinary Medicine and Institute of Veterinary Science, National University) ;
  • Kwon, Chang Hoon (College of Veterinary Medicine and Institute of Veterinary Science, National University) ;
  • Park, Byung Chul (R & D Institute, Sunjin Co., Ltd.) ;
  • Lee, Chul Young (The Regional Animal Industry Center, Gyeongnam National University of Science and Technology) ;
  • Han, Jeong Hee (College of Veterinary Medicine and Institute of Veterinary Science, National University)
  • Received : 2014.10.17
  • Accepted : 2014.12.29
  • Published : 2015.01.31


The study was performed to investigate the effect of dietary supplementation of a lipid-encapsulated Zinc oxide on growth parameters and intestinal mucosal morphology piglets born to Duroc-sired Landrace ${\times}$ Yorkshire dams. Twenty-four 30-day-old piglets weaned at 25 days of age were orally challenged with $5{\times}10^8$ colony forming units of enterotoxigenic Escherichia coli (ETEC) K88 and fed one of the four diets for 7 days: (i) a nursery basal diet containing 100-ppm ZnO (referred to as BASAL), (ii) BASAL supplemented with 120-ppm apramycin (referred to as ANTIBIO), (iii) BASAL with 2,400-ppm ZnO (referred to as HIGH), and BASAL containing 100-ppm lipid-encapsulated ZnO (referred to as LE). All piglets were killed at the end of the experiment for histological examination on the intestine. The results showed that the average daily gain (ADG), the villus height: crypt depth (CD) ratio in the ileum, and the goblet cell density of the villus and crypt in the duodenum, jejunum, and colon were greater in the LE-fed group that those of the BASAL (p < 0.05). Fecal consistency score (FCS) and the CD ratio in the ileum were less in the LE-fed group, compared to the BASAL-fed one (p < 0.05). The effects observed in the LE-fed group were almost equal to those of the HIGH-fed group as well as even superior to those of the ANTIBIO-fed group. Taken together, our results imply that dietary supplementation of 100-ppm lipid-encapsulated ZnO is as effective as that of 2,400-ppm ZnO for promoting growth diarrhea and intestinal morphology caused by ETEC infection.


Diarrhea;Enterotoxigenic Escherichia coli;Growth performance;Intestine;Weaning pig;Zinc oxide


Supported by : CTCBIO, Inc., Gyeongnam National University of Science and Technology


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