DOI QR코드

DOI QR Code

The Carcinogenic Liver Fluke Opisthorchis viverrini among Rural Community People in Northeast Thailand: a Cross-Sectional Descriptive Study using Multistage Sampling Technique

  • Kaewpitoon, Soraya J ;
  • Kaewpitoon, Natthawut ;
  • Rujirakul, Ratana ;
  • Ueng-arporn, Naporn ;
  • Matrakool, Likit ;
  • Tongtawee, Taweesak
  • Published : 2015.12.03

Abstract

Opisthorchis viverrini infection is a serious public health problem in Southeast Asia especially in the northeast and north of Thailand. Therefore, a cross-sectional survey using multistage sampling was conducted from the rural communities of Surin province, Thailand, during September 2013 to July 2014. O. viverrini infection was determined using Kato's thick smear technique. Socio-demographic, information resources, and history data were collected using predesigned semi-structured questionnaires. A total of 510 participants completed interviews and had stools collected. Some 32 (6.47%) participants were infected with O. viverrini. The rate was slightly higehr in males (6.61%) than females (6.32%). High frequencies were found in the age groups 61-70 (19.4%) and 71-80 years (19.4%), those involved in agriculture (10.5%), and in primary school (10.3%). The distribution of high infection was found in Tha Tum (16.7%) and Sankha district (16.7%), followed by Samrong Thap (13.3%), Si Narong (13.33%), and Buachet district (13.33%). Chi-square testing indicated that age (61-70 and 71-80 year old), education (primary school) and occupation (agriculture), were significantly associated with O. viverrini infection (p-value<0.05). Of 72.6% participants who had past histories with stool examination, 17.0% of them had been infected with O. viverrini and 43.2% treated with praziquantel. This finding confirmed that O. viverrini is still a problem in Surin province, Thailand, and therefore, interventions are urgently required for mass treatment and health education implementation.

Keywords

Carcinogenic human liver fluke;Opisthorchis viverrini;Surin;Thailand

References

  1. Harinasuta C, Vajrasthira S (1960). Opisthorchiasis in Thailand. Am J Trop Med Hyg, 54, 100-5.
  2. Harinasuta T, Riganti M, Bunnag D (1984). Opisthorchis viverrini infection: pathogenesis and clinical features. Arzneimittelforschung, 34, 1167-9.
  3. Jongsuksuntigul P, Imsomboon T (2003). Opisthorchiasis control in Thailand. Acta Trop, 88, 229-32. https://doi.org/10.1016/j.actatropica.2003.01.002
  4. Kaewpitoon N, Kaewpitoon SJ, Pengsaa P (2008). Opisthorchiasis in Thailand: review and current status. World J Gastroenterol, 14, 2297-302. https://doi.org/10.3748/wjg.14.2297
  5. Kaewpitoon SJ, Rujirakul R, Kaewpitoon N (2012). Prevalence of Opisthorchis viverrini infection in Nakhon Ratchasima province, Northeast Thailand. Asian Pac J Cancer Prev, 13, 5245-9. https://doi.org/10.7314/APJCP.2012.13.10.5245
  6. Kaewpitoon SJ, Rujirakul R, Ueng-Arporn N, et al (2012). Community-based cross-sectional study of carcinogenic human liver fluke in elderly from Surin province, Thailand. Asian Pac J Cancer Prev, 13, 4285-8. https://doi.org/10.7314/APJCP.2012.13.9.4285
  7. Kato K, Miura M (1954). Comparative examinations. Jpn J Parasitol, 3, 35.
  8. Rujirakul R, Ueng-arporn N, Kaewpitoon S, et al (2015). GISbased spatial statistical analysis of risk areas for liver flukes in Surin Province of Thailand. Asian Pac J Cancer Prev, 16, 2323-6. https://doi.org/10.7314/APJCP.2015.16.6.2323
  9. Sadun EH (1995). Studies on Opisthorchis viverrini in Thailand. Am J Hyg, 62, 81-115.
  10. Sithithaworn P, Andrews RH, Nguyen VD, et al (2012). The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitol International, 61, 10-6. https://doi.org/10.1016/j.parint.2011.08.014
  11. Sithithaworn P, Pipitgool V, Srisawangwong T, et al., (1997). Seasonal variation of Opisthorchis viverrini infection in cyprinoid fish in north-east Thailand: implications for parasite control and food safety. Bull World Health Organ, 75, 125-31.
  12. Sripa B, Bethony JM, Sithithaworn P, et al., (2011). Opisthorchiasis and Opisthorchis-associated cholangiocarcinoma in Thailand and Laos. Acta Trop, 120, 158-68. https://doi.org/10.1016/j.actatropica.2010.07.006
  13. Sripa B, Kaewkes S, Intapan PM, et al (2010). Food-borne trematodiases in Southeast Asia: epidemiology, pathology, clinical manifestation and control. Adv Parasitol, 72, 305-50. https://doi.org/10.1016/S0065-308X(10)72011-X
  14. Sripa B, Kaewkes S, Sithithaworn P, et al (2007). Liver fluke induces cholangiocarcinoma. PLoS Med, 4, 201. https://doi.org/10.1371/journal.pmed.0040201
  15. Surin Administrative Organization, Thailand. General data of Surin province. Access : http://www.surin.go.th. Retrieved date: 11 September 2013.
  16. Suwannahitatom P, Klomjit S, Naaglor T, et al (2013). A follow-up study of Opisthorchis viverrini infection after the implementation of control program in a rural community, central Thailand. Parasit Vectors, 6, 188. https://doi.org/10.1186/1756-3305-6-188
  17. Thaewnongiew K, Singthong S, Kutchamart S, et al (2014). Prevalence and risk factors for Opisthorchis viverrini infections in upper Northeast Thailand. Asian Pac J Cancer Prev, 15, 6609-12. https://doi.org/10.7314/APJCP.2014.15.16.6609
  18. Thamavit W, Bhamarapravati N, Sahaphong S, et al (1978). Effects of dimethylnitrosamine on induction of cholangiocarcinoma in Opisthorchis viverrini-infected Syrian golden hamsters. Cancer Res, 38, 4634-9.
  19. Vichasri S, Viyanant V, Upatham ES (1982). Opisthorchis viverrini: intensity and rates of infection in cyprinoid fish from an endemic focus in northeast Thailand. Southeast Asian J Trop Med Public Health, 3, 138-41.
  20. Wykoff DE, Chittayasothorn K, Winn MM (1966). Clinical manifestation of Opisthorchis viverrini infection in Thailand. Am J Trop Med Hyg, 15, 914-8. https://doi.org/10.4269/ajtmh.1966.15.914

Cited by

  1. Nurses and Television as Sources of Information Effecting Behavioral Improvement Regarding Liver Flukes in Nakhon Ratchasima Province, Thailand vol.17, pp.3, 2016, https://doi.org/10.7314/APJCP.2016.17.3.1097
  2. Effectiveness of a Health Educational Program Based on Self-Efficacy and Social Support for Preventing Liver Fluke Infection in Rural People of Surin Province, Thailand vol.17, pp.3, 2016, https://doi.org/10.7314/APJCP.2016.17.3.1111
  3. Implementation of Health Behavior Education Concerning Liver Flukes among Village Health Volunteers in an Epidemic Area of Thailand vol.17, pp.4, 2016, https://doi.org/10.7314/APJCP.2016.17.4.1713

Acknowledgement

Supported by : Suranaree University of Technology (SUT)