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Distribution Characteristics of 3,369 Chinese Colorectal Cancer Patients for Gender, Age, Location and Tumor Size During Colonoscopy

  • Cai, Bin (Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University) ;
  • Wang, Mu-Yong (Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University) ;
  • Liao, Kai (Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University) ;
  • Xu, Yan-Song (Department of Emergency Surgery, First Affiliated Hospital of Guangxi Medical University) ;
  • Wei, Wei-Yuan (Department of Gastrointestinal Surgery, First Affiliated Hospital of Guangxi Medical University) ;
  • Zhuang, Yuan (School of Preclinical Medicine, Guangxi Medical University) ;
  • Zhang, Sen (Department of Colorectal Surgery, First Affiliated Hospital of Guangxi Medical University)
  • Published : 2014.11.06

Abstract

Background: Studies have shown the existence of gender- and age-related differences in the incidence and anatomic distribution of colorectal cancers. The purposes of this study were to analyze the distribution characteristics of colorectal cancer patients regarding gender, age, location and tumor size in the course of colonoscopy. Materials and Methods: All colorectal cancer patients who underwent colonoscopy in the First Affiliated Hospital of Guangxi Medical University from 2003 to 2012 were included in our retrospective study. Demographic information (age and gender) and colonoscopy report information (tumor size and location) were collected and analyzed. To compare the gender differences in tumor location and tumor size, as well as the size differences in tumor location, the chi-square test was used. Results: A total of 3, 369 colorectal cancer patients (2, 007 men vs 1, 362 women) were included in our study. Statistical analysis showed there was no gender difference in the anatomic distribution of the tumors (p>0.05). However, there was a gender difference in tumor size (p<0.05). In addition, our study found there was a significant difference in tumor size between rectal and colon tumors (p<0.001). Conclusions: There was no gender difference in the anatomic distribution of colorectal tumors. In addition, tumors observed in men were larger than in women.

Keywords

Colorectal cancer;gender;age;location;size;China

Acknowledgement

Supported by : National Natural Science Foundation of China

References

  1. Bonithon-Kopp C, Benhamiche AM (1999). Are there several colorectal cancers? Epidemiological data. Eur J Cancer Prev, 8, 3-12. https://doi.org/10.1097/00008469-199912001-00001
  2. Brenner H, Hoffmeister M, Arndt V, et al (2007). Gender differences in colorectal cancer: implications for age at initiation of screening. Br J Cancer, 96, 828-31. https://doi.org/10.1038/sj.bjc.6603628
  3. Chlebowski RT, Wactawski-Wende J, Ritenbaugh C, et al (2004). Estrogen plus progestin and colorectal cancer in postmenopausal women. N Engl J Med, 350, 991-1004. https://doi.org/10.1056/NEJMoa032071
  4. Chong VH (2012). Gender preference and implications for screening colonoscopy: impact of endoscopy nurses. World J Gastroenterol, 18, 3590-4. https://doi.org/10.3748/wjg.v18.i27.3590
  5. Effendi YSR, Zain LH, Siregar GA, et al (2013). Adenomatous Polyposis Coli, mismatch repair, and microsatellite instability in colorectal cancer based on different locations. Acta Med Indones, 45, 275-83.
  6. Elbanna HG, Ebrahim MA, Abbas AM, et al (2012). Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index. J Gastrointest Cancer, 43, 56-62.
  7. Hwang H (2013). Colorectal cancer screening among Asian Americans. Asian Pac J Cancer Prev, 14, 4025-32. https://doi.org/10.7314/APJCP.2013.14.7.4025
  8. Fang YJ, Lu ZH, Wang F, et al (2010). Prognostic impact of ERbeta and MMP7 expression on overall survival in colon cancer. Tumour Biol, 31, 651-8. https://doi.org/10.1007/s13277-010-0082-0
  9. Giovannucci E (2002). Modifiable risk factors for colon cancer. Gastroenterol Clin North Am, 31, 925-43.
  10. Grodstein F, Newcomb PA, Stampfer MJ (1999). Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis. Am J Med, 106, 574-82. https://doi.org/10.1016/S0002-9343(99)00063-7
  11. Jacobs ET, Thompson PA, Martinez ME (2007). Diet, gender, and colorectal neoplasia. J Clin Gastroenterol, 41, 731-46. https://doi.org/10.1097/MCG.0b013e3180338e56
  12. Jassam N, Bell SM, Speirs V, et al (2005). Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging. Oncol Rep, 14, 17-21.
  13. Kennelly R, Kavanagh DO, Hogan AM, et al (2008). Oestrogen and the colon: potential mechanisms for cancer prevention. Lancet Oncol, 9, 385-91. https://doi.org/10.1016/S1470-2045(08)70100-1
  14. Kornprat P, Pollheimer MJ, Lindtner RA, et al (2011). Value of tumor size as a prognostic variable in colorectal cancer: a critical reappraisal. Am J Clin Oncol, 34, 43-9. https://doi.org/10.1097/COC.0b013e3181cae8dd
  15. Kotepui M, Piwkham D, Songsri A, et al (2013). Histopathology analysis of benign colorectal diseases and colorectal cancer in Hatyai Hospital, Songkhla, Thailand. Asian Pac J Cancer Prev, 14, 2667-71. https://doi.org/10.7314/APJCP.2013.14.4.2667
  16. Larsson SC, Wolk A (2006). Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Int J Cancer, 119, 2657-64. https://doi.org/10.1002/ijc.22170
  17. Mogoanta SS, Vasile I, Totolici B, et al (2014). Colorectal cancer - clinical and morphological aspects. Rom J Morphol Embryol, 55, 103-10.
  18. Levin B, Lieberman DA, McFarland B, et al (2008). Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology, 134, 1570-95. https://doi.org/10.1053/j.gastro.2008.02.002
  19. Magaji BA, Moy FM, Roslani AC, et al (2014). Descriptive epidemiology of colorectal cancer in University Malaya Medical Centre, 2001 to 2010. Asian Pac J Cancer Prev, 15, 6059-64. https://doi.org/10.7314/APJCP.2014.15.15.6059
  20. McCashland TM, Brand R, Lyden E, et al (2001). Gender differences in colorectal polyps and tumors. Am J Gastroenterol, 96, 882-6. https://doi.org/10.1111/j.1572-0241.2001.03638.x
  21. Morrison DS, Batty GD, Kivimaki M, et al (2011). Risk factors for colonic and rectal cancer mortality: evidence from 40 years' follow-up in the Whitehall I study. J Epidemiol Community Health, 65, 1053-8. https://doi.org/10.1136/jech.2010.127555
  22. Nawa T, Kato J, Kawamoto H, et al (2008). Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology. J Gastroenterol Hepatol, 23, 418-23. https://doi.org/10.1111/j.1440-1746.2007.04923.x
  23. Omranipour R, Doroudian R, Mahmoodzadeh H (2012). Anatomical distribution of colorectal carcinoma in Iran: a retrospective 15-yr study to evaluate rightward shift. Asian Pac J Cancer Prev, 13, 279-82. https://doi.org/10.7314/APJCP.2012.13.1.279
  24. Papaxoinis K, Triantafyllou K, Sasco AJ, et al (2010). Subsitespecific differences of estrogen receptor beta expression in the normal colonic epithelium: implications for carcinogenesis and colorectal cancer epidemiology. Eur J Gastroenterol Hepatol, 22, 614-9. https://doi.org/10.1097/MEG.0b013e328335ef50
  25. Rundle AG, Lebwohl B, Vogel R, et al (2008). Colonoscopic screening in average-risk individuals ages 40 to 49 vs 50 to 59 years. Gastroenterology, 134, 1311-5. https://doi.org/10.1053/j.gastro.2008.02.032
  26. Shah SA, Neoh HM, Rahim SS, et al (2014). Spatial analysis of colorectal cancer cases in Kuala Lumpur. Asian Pac J Cancer Prev, 15, 1149-54. https://doi.org/10.7314/APJCP.2014.15.3.1149
  27. Siegel R, Ma J, Zou Z, et al (2014a). Cancer statistics, 2014. CA Cancer J Clin, 64, 9-29. https://doi.org/10.3322/caac.21208
  28. Siegel R, Desantis C, Jemal A (2014b). Colorectal cancer statistics, 2014. CA Cancer J Clin, 64, 104-17. https://doi.org/10.3322/caac.21220
  29. Sung JJ, Lau JY, Young GP, et al (2008). Asia Pacific consensus recommendations for colorectal cancer screening. Gut, 57, 1166-76. https://doi.org/10.1136/gut.2007.146316

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