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Impact of Chemotherapy-Related Hyperglycemia on Prognosis of Child Acute Lymphocytic Leukemia

  • Zhang, Bi-Hong (Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) ;
  • Wang, Jian (Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) ;
  • Xue, Hong-Man (Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) ;
  • Chen, Chun (Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University)
  • Published : 2014.11.06

Abstract

Purpose: To investigate the impact of hyperglycemia during inductive treatment on the prognosis of acute lymphocytic leukemia (ALL) in children. Materials and Methods: Clinical data of 159 ALL childhood cases were reviewed. The patients were divided into the hyperglycemia group (fasting $glucose{\geq}126mg/dl$ and/or random blood $glucose{\geq}200mg/dl$) and the euglycemia group according to the blood glucose values. The X2 test was performed to compare the complete remission rates of the two groups, and Kaplan-Meier and log-rank tests were performed to compare the 5-year overall and relapse-free survival. Results: The incidence of hyperglycemia in the $age{\geq}10-year-old$ group was higher than the younger-age group (P=0.009). Values in the interim- and high-risk groups were higher than the standard-risk group (P=0.028), while there was no significant difference between genders (P=0.056). The complete remission rates of the 2 groups demonstrated no significant difference (P=0.134), while the 5-year OS of the hyperglycemia group was lower than in the euglycemia group ($83.8{\pm}6.0%$ vs $94.9{\pm}2.4%$, P=0.014). The 5 -year RFS was significantly lower than the euglycemia group ($62.9{\pm}8.7%$) vs $80.2{\pm}9.1%$, P<0.001). Conclusions: Children with $age{\geq}10year$ old, and in the middle- and high-risk groups appear prone to complicating hyperglycemia during inductive chemotherapy, associated with lower 5-year OS and RFS.

Keywords

Childhood ALL;chemotherapy-related hyperglycemia;relapse-free rate;overall survival

Acknowledgement

Supported by : National Nature Scientific Grant of China

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