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Treatment Efficacy and Prognostic Factors for Huge HCC Based on Barcelona Clinic Liver Cancer Staging

  • Zhang, Zhi-Ming (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Zhang, Yu-Mei (Department of Chemotherapy, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Gao, Sheng (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Yuan, Wei-Ping (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Zhao, Yin-Nong (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Xiang, Bang-De (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Wu, Fei-Xiang (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Wu, Guo-Bin (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University) ;
  • Liu, Jian-Yong (Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University)
  • Published : 2014.11.06

Abstract

Objective: To explore the most appropriate treatment for patients with hepatocellular cancer (HCC) >10 cm by using the Barcelona Clinic Liver Cancer (BCLC) classification. Materials and Methods: A total of 124 HCC patients undergoing surgery were selected. Disease-free survival (DFS), overall survival (OS) and prognostic factors were respectively assessed. Results: This study showed that the cumulative 1-, 3-, 5-year survival rates were 79.7%, 59.8% and 41.6% in BCLC-A patients, 76.2%, 9.5% and 0% in BCLC-B patients and 44.9%, 0% and 0% in BCLC-C patients, respectively. The 1-, 3-, 5-year DFS rates were 49%, 24.5% and 9.1% in BCLC-A patients, 7.5%, 0% and 0% in BCLC-B patients, respectively. No BCLC-C patients survived 1 year after surgery. Multivariate analysis indicated that hepatitis B surface antigen (HBsAg), vascular invasion, intra-hepatic metastasis, curative resection, tumor rupture and pathologic differentiation were independent prognostic factors. Conclusions: Surgery is effective and safe for patients with HCC >10 cm with sufficient hepatic reserve.

Keywords

Barcelona clinic liver cancer staging;huge hepatocellular carcinoma;hepatectomy;efficacy

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