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Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

  • Chen, Ying (School of Public Health, Hebei United University) ;
  • Fan, Xue-Yun (School of Public Health, Hebei United University) ;
  • Jin, Yu-Lan (School of Public Health, Hebei United University) ;
  • Yao, San-Qiao (School of Public Health, Hebei United University) ;
  • Yun, Xiang (School of Public Health, Hebei United University) ;
  • Hua, Zheng-Bing (School of Public Health, Hebei United University) ;
  • Shen, Fu-Hai (School of Public Health, Hebei United University)
  • Published : 2014.11.06

Abstract

Background: To explore the relationship between polymorphisms of interleukin17 (IL-17) gene(A-832G 7488A/G) and the susceptibility to silicosis, a risk factor for lung cancer. Materials and Methods: A total of 113 silicosis patients and 116 workers without silicosis were enrolled in the case-control study. IL-17A A-832G and IL-17F 7488A/G polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of AA,GG and AG of IL-17A A-832G locus in the case and control groups were 46.9%, 8.0%, 45.1%, and 49.2%, 7.6%, 43.2%, respectively, with no significant differences (p>0.05).The GG genotype in the IL-17F (7488A/G) locus was not found. The frequencies of AA and GA of IL-17F 7488A/G locus in the case and control groups were 84.1%, 15.9% and 66.4%, 33.6%, respectively (p<0.05). Analysis of combined effects showed that the individuals with GG+AG genotype of IL-17A and GG+GA genotype of IL-17F are protected against silicosis (OR=0.469). Conclusions: IL-17F 7488A/G is associated with susceptibility to silicosis, and G allele may have a protective effect. No relationship was found between IL-17A gene polymorphisms at A-832G and silicosis.

Keywords

Silicosis;IL-17A, IL-17F;polymorphism;disease susceptibility;combined effect

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