DOI QR코드

DOI QR Code

Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

  • Chen, Ying (School of Public Health, Hebei United University) ;
  • Fan, Xue-Yun (School of Public Health, Hebei United University) ;
  • Jin, Yu-Lan (School of Public Health, Hebei United University) ;
  • Yao, San-Qiao (School of Public Health, Hebei United University) ;
  • Yun, Xiang (School of Public Health, Hebei United University) ;
  • Hua, Zheng-Bing (School of Public Health, Hebei United University) ;
  • Shen, Fu-Hai (School of Public Health, Hebei United University)
  • Published : 2014.11.06

Abstract

Background: To explore the relationship between polymorphisms of interleukin17 (IL-17) gene(A-832G 7488A/G) and the susceptibility to silicosis, a risk factor for lung cancer. Materials and Methods: A total of 113 silicosis patients and 116 workers without silicosis were enrolled in the case-control study. IL-17A A-832G and IL-17F 7488A/G polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of AA,GG and AG of IL-17A A-832G locus in the case and control groups were 46.9%, 8.0%, 45.1%, and 49.2%, 7.6%, 43.2%, respectively, with no significant differences (p>0.05).The GG genotype in the IL-17F (7488A/G) locus was not found. The frequencies of AA and GA of IL-17F 7488A/G locus in the case and control groups were 84.1%, 15.9% and 66.4%, 33.6%, respectively (p<0.05). Analysis of combined effects showed that the individuals with GG+AG genotype of IL-17A and GG+GA genotype of IL-17F are protected against silicosis (OR=0.469). Conclusions: IL-17F 7488A/G is associated with susceptibility to silicosis, and G allele may have a protective effect. No relationship was found between IL-17A gene polymorphisms at A-832G and silicosis.

References

  1. Arisawa T, Tahara T, Shibata T, et al (2007). Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia. Int J Mol Med, 20, 717-23.
  2. Arisawa T, Tahara T, Shibata T, et al (2008). The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. J Clinical Immunology, 28, 44-9. https://doi.org/10.1007/s10875-007-9125-8
  3. Berran Yucesoy, Val Vallyathan, Douglas P, et al (2001). Association of Tumor Necrosis Factor-$\alpha$ and Interleukin-1 Gene Polymorphisms with Silicosis. Toxicol Appl Pharm, 172, 75-82. https://doi.org/10.1006/taap.2001.9124
  4. Bazzi MD, Sultan MA, Tassan NA (2011). Interleukin17A and F and asthma in Saudi Arabia: gene polymorphisms and Protein Levels. J Investig Allergol Clin Immunol, 21, 551-5.
  5. Chen W, Liu Y, Wang H, et al (2012). Long-term exposure to silica dust and risk of total and cause-specific mortality in Chinese workers: a cohort study. PLoS Med, 9, 1001206. https://doi.org/10.1371/journal.pmed.1001206
  6. Dong Z, Kang Q, Lei W, et al (2012). Effects of interleukin-17 on murine pulmonary fibroblast proliferation transformation and collagen synthesis. Europepmc Org, 32, 75-9.
  7. Hayashi R, Tahara T, Shiroeda H, et al (2012). Association of genetic polymorphisms in IL-17A and IL-17F with gastroduodenal diseases. Original Papers, 21, 243-9.
  8. Fayaz S, Karimmirza M, Tanhaei S, et al (2013). Increased risk of differentiate -d thyroid carcinoma with combined effects of homologous recombination repair gene polymorphisms in an Iranian population. Asian Pac J Cancer Prev, 14, 6727-31. https://doi.org/10.7314/APJCP.2013.14.11.6727
  9. Gaffen SL (2008). An overview of IL-17 function and signaling. Cytokine, 43, 402-7. https://doi.org/10.1016/j.cyto.2008.07.017
  10. Gao C M, Ding J H, Li S P, et al (2013). Polymorphisms in XRCC1 gene, alcohol drinking, and risk of colorectal cancer:case-control study in Jiangsu Province of China. Asian Pac J Cancer Prev, 14, 6613-8. https://doi.org/10.7314/APJCP.2013.14.11.6613
  11. Kawaguchi M, Takahashi D, Hizawa N, et al (2006). IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J Allergy Clin Immun, 117, 795-801. https://doi.org/10.1016/j.jaci.2005.12.1346
  12. Kaabachi W, Amor A B, Kaabachi S (2014). Interleukin-17A and -17F genes polymorphisms in lung cancer. Science Direct, 66, 123-9.
  13. Li Q, Wang J M, Peng Y, et al (2013). Association of DNA Base-excision Repair XRCC1, OGG1 and APE1 gene polymorphisms with nasopharyngeal carcinoma susceptibility in a Chinese population. Asian Pac J Cancer Prev, 14, 5145-51. https://doi.org/10.7314/APJCP.2013.14.9.5145
  14. Mo let S, H amid Q, Davoine F, et al (2001). IL-17 is in creased in asthmatic airways and induces hum an bronchial fibroblasts to produce cytokines. J Allergy C lin Immunol, 108, 430-8. https://doi.org/10.1067/mai.2001.117929
  15. Naidoo RN, Robins TG, Murray J (2005). Respiratory outcomes among South African coal miners at autopsy. Am J Ind Med, 48, 217-24. https://doi.org/10.1002/ajim.20207
  16. Quan Y, Zhou B, Wang Y et al (2012). Association between IL17polymorphisms and risk of cervical cancer in Chinese women. Clin Dev Immunol, 258-93.
  17. Oyunbileg S, Wang JD, Sumberzul N, et al (2011). Health impact of pneumoconiosis in Mongolia: estimation of losses in life expectancy and quality adjusted life expectancy. Am J Ind Med, 54, 285-92. https://doi.org/10.1002/ajim.20930
  18. Paradowska-Gorycka A, Wojtecka-Lukasik E, Trefler J, et al (2010). Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA). Scand J Immunol, 72, 134-41. https://doi.org/10.1111/j.1365-3083.2010.02411.x
  19. Pingle S (2012). Occupational safety and health in India: now and the future. Ind Health, 50, 167-71. https://doi.org/10.2486/indhealth.MS1366
  20. Spielman R S, Bastone L A, Burdick J T, et al (2007). Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet, 39, 226-31. https://doi.org/10.1038/ng1955
  21. Simonian PL, Roark CL, Wehrmann F, et al (2009). Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis. J Immunol, 182, 657-65. https://doi.org/10.4049/jimmunol.182.1.657
  22. Shibata T, Tahara T, Hirata I, et al (2009). Genetic polymorphism of interleukin-17A and interleukin-17F genes in gastric carcinogenesis. Hum Immunol, 70, 547-56. https://doi.org/10.1016/j.humimm.2009.04.030
  23. Shu Q, Yang P, Hou S, et al (2010). Interleukin-17 gene polymorphism is associated with Vogt-Koya nagi-Harada syndr-ome but not with Behcet's disease in a chinese Han population. Hum Imm Unol, 71, 988-91. https://doi.org/10.1016/j.humimm.2010.06.020
  24. Wang H, Kim HY (2005). Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients. Mol Cells, 19, 180-4.
  25. Wang L, Jiang Y, Zhang Y et al (2012). Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. PLoS ONE, 7, 34400. https://doi.org/10.1371/journal.pone.0034400
  26. Wu X Q, Zeng Z R, Chen B, et al (2012). Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. InT J Cancer, 127, 86-92.
  27. Luo Y (2010). Association analysis of interleukin-17 genes' single nucleotide polymorphisms (SNPs) with H.pylori infection associated gastric disease in Chinese population. Third Military Medical University.
  28. Zhang G Q, Han F, Fang X Z, et al (2012). CD4, IL17 and Foxp3 expression in different pTNM stages of operable non-small cell lung cancer and effects on disease prognosis. Asian Pac J Cancer Prev, 13, 3955-60. https://doi.org/10.7314/APJCP.2012.13.8.3955

Cited by

  1. Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana vol.21, pp.5, 2016, https://doi.org/10.1007/s10147-016-0972-2
  2. Association between SNPs at IL-17A and IL-17F and susceptibility to accelerated silicosis vol.33, pp.9, 2017, https://doi.org/10.1177/0748233717695431
  3. Tumor necrosis factor gene polymorphisms are associated with silicosis: a systemic review and meta-analysis vol.39, pp.2, 2019, https://doi.org/10.1042/BSR20181896