DOI QR코드

DOI QR Code

Prevalence of Local Recurrence of Colorectal Cancer at the Iranian Cancer Institute

  • Omranipour, Ramesh (Department of Surgical Oncology, Faculty of Medicine, Cancer Institute, Tehran University of Medical Sciences) ;
  • Mahmoodzadeh, Habibollah (Department of Surgical Oncology, Faculty of Medicine, Cancer Institute, Tehran University of Medical Sciences) ;
  • Safavi, Farinaz (Neurology, Faculty of Medicine, Thomas Jefferson University)
  • Published : 2014.11.06

Abstract

Background: Although a great deal of progress has been made in the management of colorectal cancer in terms of neoadjuvant modalities, surgical techniques and adjuvant therapies, the recurrence of tumors remains an enigmatic complication in patients. A better understanding of colorectal cancer and of factors that lead to recurrence of disease can provide helpful information for designing more effective screening and surveillance methods. Aim: To investigate the factors that may lead to local recurrence of colorectal cancers. Materials and Methods: The current retrospective case study evaluated 617 patients admitted to the Iranian Cancer Institute (the largest referral cancer center in the country) from 1995 to 2009 with confirmed colorectal cancer. Patients with distant metastasis, or with pathology other than adenocarcinoma and no follow-up, were excluded (175 patients). The remainder (442) included 294 (66.5%) with rectal cancer and 148 (33.5%) with colon cancer. The median duration of follow-up was 26 months. Results: The total rate of recurrence was 17.4%, comprising 19.6% and 16.3% recurrence rates in colon and rectal cancer, respectively. Conclusions: Recurrence of colorectal cancer was significantly correlated to tumor grade (p<0.008).

Keywords

Colorectal cancer;recurrence;grade;stage;prevalence;Iran

Acknowledgement

Supported by : Tehran University of Medical Science

References

  1. Compton CC (2002). Surgical pathology of colorectal cancer. Clin Colorectal Cancer, 2, 149-60 . https://doi.org/10.3816/CCC.2002.n.020
  2. Adsay NY, Klimstra DS (2005). Not all “mucinous carcinomas” are equal: time to redefine and reinvestigate the biologic significance of mucin types and patterns in the GI tract. Virchows Arch, 447, 111-2. https://doi.org/10.1007/s00428-005-1234-2
  3. Andreoni B, Chiappa A, Bertani E, et al (2007). Surgical outcomes for colon and rectal cancer over a decade: results from a consecutive monocentric experience in 902 unselected patients. World J SurgOncol, 4, 73-7.
  4. Center MM, Jemal A, Ward E (2009). International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev, 18, 1688-94. https://doi.org/10.1158/1055-9965.EPI-09-0090
  5. Cusack JC, Giacco GG, Cleary K, et al (1996). Survival factors in 186 patients younger than 40 years old with colorectal adenocarcinoma. J Am CollSurg, 183, 105-9.
  6. Doll D, Gertler R, Maak M, et al (2009). Reduced lymph node yield in rectal carcinoma specimen after neoadjuvant radiochemotherapy has no prognostic relevance. World J Surg, 33, 340-7. https://doi.org/10.1007/s00268-008-9838-8
  7. Enriquez JM, Diez M, Tobaruela E, et al (1998). Clinical, histopathological,cytogenetic and prognostic differences between mucinous and nonmucinous colorectal adenocarcinomas. RevEspEnferm Dig, 90, 563-72.
  8. Farhat MH, Barada KA, Tawil AN, et al (2008). Effect of mucin production on survival in colorectal cancer: a case-control study. World J Gastroenterol, 14, 6981-5. https://doi.org/10.3748/wjg.14.6981
  9. Ferenschild FT, Vermaas M, Verhoef C (2009). Total pelvic exenteration for primary and recurrent malignancies. World J Surg, 33, 1502-8. https://doi.org/10.1007/s00268-009-0066-7
  10. Halvorsen TB (1986). ABO blood groups, rhesus types, and colorectal adenocarcinoma. A retrospective study of 747 cases. Scand J Gastroenterol, 21, 979-83. https://doi.org/10.3109/00365528608996408
  11. Fazeli MS, Adel MG, Lebaschi AH (2007), Colorectal carcinoma: a retrospective, descriptive study of age, gender, subsite, stage, and differentiation in Iran from 1995 to 2001 as observed in Tehran University. Dis Colon Rectum, 50,990-5. https://doi.org/10.1007/s10350-007-0248-z
  12. Fearon ER, Cho KR, Nigro JM, et al (1990). Identification of a chromosome 18q gene that is altered in colorectal cancers. Science, 247, 49-55. https://doi.org/10.1126/science.2294591
  13. Greene FL, Stewart AK, Norton HJ (2002). A new TNM staging strategy for node-positive (stage III) colon cancer: an analysis of 50, 042 patients. Ann Surg, 236, 416-20. https://doi.org/10.1097/00000658-200210000-00003
  14. Hansen MH, Balteskard L, Dorum LM, Eriksen MT, Vonen B (2009). Norwegian colorectal cancer group, locally recurrent rectal cancer in Norway. Br J Surg, 96, 1176-82. https://doi.org/10.1002/bjs.6699
  15. Khalili H, Wolpin BM, Huang ES, et al (2011). ABO blood group and risk of colorectal cancer. CancerEpidemiol Biomarkers Prev, 20, 1017-20. https://doi.org/10.1158/1055-9965.EPI-10-1250
  16. Knut M. Augestad, Rolv-Ole Lindsetmo, Jonah Stulberg et al (2010). International preoperative rectal cancer management: staging,neoadjuvant treatment, and impact of multidisciplinary teams. World J Surg, 34, 2689-700. https://doi.org/10.1007/s00268-010-0738-3
  17. Kraemer M, Wiratkapun S, Seow-Choen F, et al (2001). Stratifying risk factors for follow-up: a comparison ofrecurrent and nonrecurrent colorectal cancer. Dis Colon Rectum, 44, 815-21. https://doi.org/10.1007/BF02234700
  18. Li M, Li JY, Zhao AL, Gu J (2007). Colorectal cancer or colon and rectal cancer ? clinicopathological comparison between colonic and rectal carcinomas. Oncology, 73, 52-7. https://doi.org/10.1159/000120628
  19. Messerini L, Palomba A, Zampi G (1995). Primary signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum, 38, 1189-93. https://doi.org/10.1007/BF02048335
  20. Soreide K, Soreide JA, Korner H (2011). Prognostic role of carcinoembryonic antigen is infuenced by microsatellite instability genotype and stage in locally advanced colorectal cancers. World J Surg, 35, 888-94. https://doi.org/10.1007/s00268-011-0979-9
  21. Nadoshan JJ, Omranipour R, Beiki O, et al (2013). Prognostic value of lymph node ratios in node positive rectal cancer treated with preoperative chemoradiation. APJCP, 14, 3769-72. https://doi.org/10.7314/APJCP.2013.14.6.3769
  22. Omranipour R, Doroudian R, Mahmoodzadeh H (2012). Anatomical distribution of colorectal carcinoma in Iran: a retrospective 15-year study to evaluate rightward shift. Asian Pac J Cancer Prev, 13, 279-82. https://doi.org/10.7314/APJCP.2012.13.1.279
  23. Renato Costi, CinziaAzzoni, Federico Marchesi, et al (2011). Repeated anastomotic recurrence of colorectal tumors: Genetic analysis of two cases. World J Gastroenterol, 17, 3752-8. https://doi.org/10.3748/wjg.v17.i32.3752
  24. Staib L, Link KH, Blatz A, Beger HG (2002). Surgery of colorectal cancer: surgical morbidity and five-and ten-year results.in 2400 patients-monoinstitutional experience. World J Surg, 26, 59-66. https://doi.org/10.1007/s00268-001-0182-5
  25. Vakili C, FatourechiV (1976). Age distribution of patients with carcinoma of the colon in a general hospital in Iran. Surgery, 79, 118-9.
  26. Wang H, Wei XZ, Fu CG (2010). Patterns of lymph node metastasis are different in colon and rectal car-cinomas. World J Gastroenterology, 16, 5375-9. https://doi.org/10.3748/wjg.v16.i42.5375
  27. Wiig JN, Larsen SG, Dueland S (2007). Preoperative irradiation and surgery for local recurrence of rectal and rectosigmoid cancer. Prognostic factors with regard to survival and further local recurrence. Colorectal Disease, 10, 48-57.

Cited by

  1. Colorectal Cancer Patient Characteristics, Treatment and Survival in Oman - a Single Center Study vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.4853
  2. microRNA Expression Profile in Patients with Stage II Colorectal Cancer: A Turkish Referral Center Study vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.1851
  3. Prognostic Factors and the Role of Adjuvant Chemotherapy in Post-curative Surgery for Dukes B and C Colon Cancers and Survival Outcomes: a Malaysian Experience vol.16, pp.6, 2015, https://doi.org/10.7314/APJCP.2015.16.6.2237
  4. Association of XRCC1 Arg399Gln Polymorphism with Colorectal Cancer Risk: A HuGE Meta Analysis of 35 Studies vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3285