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Breast Cancer Risk Factors in Women Participating in a Breast Screening Program: a Study on 11,850 Iranian Females

  • Sepandi, Mojtaba (Epidemiology Department, School of Public Health, Shiraz University of Medical Sciences) ;
  • Akrami, Majid (Breast Diseases Research Center, Shiraz University of Medical Sciences) ;
  • Tabatabaee, Hamidreza (Epidemiology Department, School of Public Health, Shiraz University of Medical Sciences) ;
  • Rajaeefard, Abdolreza (Epidemiology Department, School of Public Health, Shiraz University of Medical Sciences) ;
  • Tahmasebi, Sedigheh (Breast Diseases Research Center, Shiraz University of Medical Sciences) ;
  • Angali, Kambiz Ahmadi (Biostatistics and Epidemiology, Health School, Jundishapur University of Medical Sciences) ;
  • Rezaianzadeh, Abbas (Colorectal Research Center, Shiraz University of Medical Sciences) ;
  • Talei, Abdolrasoul (Breast Diseases Research Center, Shiraz University of Medical Sciences)
  • Published : 2014.10.23

Abstract

The incidence rate of breast cancer in developed countries is almost three-fold higher than in developing countries. Iran has had one of the lowest incidence rates for breast cancer in the world, but during the recent decades a marked increase has been seen. The purpose of this study was to investigate some established risk factors of breast cancer in Iranian women. A study of 11,850 women participating in abreast screening program was conducted. The 197 women diagnosed with breast cancer and 11,653 healthy women were compared. Logistic regression was performed to investigate associations of reproductive and anthropometric factors with breast cancer risk. Family history of breast cancer (OR=1.94, 95%CI=1.35-2.78), occupation (OR= 1.65,95%CI=1.20-2.25), education level (OR=0.50,95%CI=0.28-0.91), parity (OR=0.27, 95%CI=0.12-0.59), menopausal status (OR=3.15, 95%CI=2.35-4.21), age at menarche (OR=0.33, 95%CI=0.15-0.70), and age at the first pregnancy (OR=4.10, 95%CI=1.13-14.77) were related to the risk of breast cancer. Decrease in parity may to some extent explain the rising trend of incidence of breast cancer incidence in Iranian women.

Keywords

Breast neoplasms;risk factors;screening program;epidemiology;Iran

References

  1. Dey S, Soliman AS (2010). Cancer in the global health era: opportunities for the Middle East and Asia. Asia Pac J Pub Health, 22, 75-82. https://doi.org/10.1177/1010539510372846
  2. Abbasi-Shavazi MJ, Hosseini-Chavoshi M, McDonald P (2007). The path to below replacement fertility in the islamic republic of Iran. Asia Pac Popul J, 22.
  3. Clemons M, Goss P (2001). Estrogen and the risk of breast cancer. N Engl J med, 344, 276-85. https://doi.org/10.1056/NEJM200101253440407
  4. Das S, Sen S, Mukherjee A, et al (2012). Risk factors of breast cancer among women in eastern India: a tertiary hospital based case control study. Asian Pac J Cancer Prev, 13, 4979-81. https://doi.org/10.7314/APJCP.2012.13.10.4979
  5. Ghiasvand R, Maram ES, Tahmasebi S, et al (2011). Risk factors for breast cancer among young women in southern Iran. Int J Cancer, 129, 1443-9. https://doi.org/10.1002/ijc.25748
  6. do Carmo Franca-Botelho A, Ferreira M, Franca J, et al (2012). Breastfeeding and its relationship with reduction of breast cancer: a review. Asian Pac J Cancer Prev, 13, 5327-32. https://doi.org/10.7314/APJCP.2012.13.11.5327
  7. Gajalakshmi V, Mathew A, Brennan P, et al (2009). Breastfeeding and breast cancer risk in India: A multicenter case-control study. Int J Cancer, 125, 662-5. https://doi.org/10.1002/ijc.24429
  8. Ghiasvand R, Bahmanyar S, Zendehdel K, et al (2012). Postmenopausal breast cancer in Iran; risk factors and their population attributable fractions. BMC Cancer, 12, 414. https://doi.org/10.1186/1471-2407-12-414
  9. Harirchi I, Azary S, Montazeri A, et al (2012). Literacy and breast cancer prevention: a population-based study from Iran. Asian Pac J Cancer Prev, 13, 3927-30. https://doi.org/10.7314/APJCP.2012.13.8.3927
  10. Hinkula M, Pukkala E, Kyyronen P, et al (2002). Grand multiparity and incidence of endometrial cancer: A population-based study in Finland. Int J Cancer, 98, 912-5. https://doi.org/10.1002/ijc.10267
  11. Huo D, Adebamowo C, Ogundiran T, et al (2008). Parity and breastfeeding are protective against breast cancer in Nigerian women. Br J Cancer, 98, 992-6. https://doi.org/10.1038/sj.bjc.6604275
  12. Jalal Abbasi-Shavazi M, McDonald P (2006). Fertility decline in the islamic republic of Iran: 1972-2000. Asian Population Studies, 2, 217-37. https://doi.org/10.1080/17441730601073789
  13. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  14. Lea CS, Gordon NP, Prebil LA, et al (2009). Differences in reproductive risk factors for breast cancer in middleaged women in Marin County, California and a sociodemographically similar area of Northern California. BMC Women's Health, 9, 6. https://doi.org/10.1186/1472-6874-9-6
  15. Naieni KH, Ardalan A, Mahmoodi M, et al (2007). Risk factors of breast cancer in north of Iran: a case-control in Mazandaran Province. Asian Pac Jcancer Prev, 8, 395.
  16. MacMahon B, Cole P, Lin T, et al (1970). Age at first birth and breast cancer risk. Bull WHO, 43, 209.
  17. McCredie M, Paul C, Skegg DC, et al (1998). Reproductive factors and breast cancer in New Zealand. Int J Cancer, 76, 182-8. https://doi.org/10.1002/(SICI)1097-0215(19980413)76:2<182::AID-IJC3>3.0.CO;2-T
  18. Mousavi SM, Montazeri A, Mohagheghi MA, et al (2007). Breast cancer in Iran: an epidemiological review. Breast J, 13, 383-91. https://doi.org/10.1111/j.1524-4741.2007.00446.x
  19. Peeters P, Verbeek A, Krol A, et al (1995). Age at menarche and breast cancer risk in nulliparous women. Breast Cancer Res Treat, 33, 55-61. https://doi.org/10.1007/BF00666071
  20. Ren S-MW (2012). Risk assessment of breast cancer in Guangdong, China: a community-based survey. Asian Pac J Cancer Prev, 13, 2759-63. https://doi.org/10.7314/APJCP.2012.13.6.2759
  21. Rezaianzadeh A, Heydari S, Hosseini H, et al (2011). Prevalence of breast cancer in a defined population of Iran. Iran Red Crescent Med J, 13, 647.
  22. Ronco AL, De Stefani E, Deneo-Pellegrini H (2012a). Risk factors for premenopausal breast cancer: a case-control study in Uruguay. Asian Pac J Cancer Prev, 13, 2879-86. https://doi.org/10.7314/APJCP.2012.13.6.2879
  23. Ronco AL, De Stefani E, Deneo-Pellegrini H, et al (2012b). Diabetes, overweight and risk of postmenopausal breast cancer: a case-control study in Uruguay. Asian Pac J Cancer Prev, 13, 139-46. https://doi.org/10.7314/APJCP.2012.13.1.139
  24. Russo J, Moral R, Balogh GA, et al (2005). The protective role of pregnancy in breast cancer. Breast Cancer Res, 7, 131-42. https://doi.org/10.1186/bcr1029
  25. Sangrajrang S, Chaiwerawattana A, Ploysawang P, et al (2013). Obesity, diet and physical inactivity and risk of breast cancer in Thai women. Asian Pac J Cancer Prev, 14, 7023-7. https://doi.org/10.7314/APJCP.2013.14.11.7023
  26. Toleutay U, Reznik V, Kalmatayeva Z, et al (2013). Risk factors of breast cancer in Kyzylorda oblast of Kazakhstan: a casecontrol study. Asian Pac J Cancer Prev, 14, 5961-4. https://doi.org/10.7314/APJCP.2013.14.10.5961
  27. Sprague BL, Trentham-Dietz A, Egan KM, et al (2008). Proportion of invasive breast cancer attributable to risk factors modifiable after menopause. Am J Epidemiol, 168, 404-11. https://doi.org/10.1093/aje/kwn143
  28. Taghavi A, Fazeli Z, Vahedi M, et al (2012). Increased trend of breast cancer mortality in Iran. Asian Pac J Cancer Prev, 13, 367-70. https://doi.org/10.7314/APJCP.2012.13.1.367
  29. Tehard B, Lahmann PH, Riboli E, et al (2004). Anthropometry, breast cancer and menopausal status: Use of repeated measurements over 10 years of follow-up-results of the French E3N women's cohort study. Int J Cancer, 111, 264-9. https://doi.org/10.1002/ijc.20213
  30. Yadav NK, Poudel B, Thanpari C, et al (2012). Assessment of biochemical profiles in premenopausal and postmenopausal women with breast cancer. Asian Pac J Cancer Prev, 13, 3385-8. https://doi.org/10.7314/APJCP.2012.13.7.3385
  31. Yavari P, Mosavizadeh M, Sadrol-Hefazi B, et al (2004). Reproductive characteristics and the risk of breast cancer--a case-control study in Iran. Asian Pac J Cancer Prev, 6, 370-5.
  32. Zare N, Haem E, Lankarani KB, et al (2013). Breast cancer risk factors in a defined population: weighted logistic regression approach for rare events. J Breast Cancer, 16, 214-9. https://doi.org/10.4048/jbc.2013.16.2.214

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