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Lack of Prognostic Significance of SOCS-1 Expression in Colorectal Adenocarcinomas

  • Ayyildiz, Talat (Department of Gastroenterology, School of Medicine, Ondokuz Mayis University) ;
  • Dolar, Enver (Department of Gastroenterology, School of Medicine, Uludag University) ;
  • Adim, Saduman Balaban (Department of Pathology, School of Medicine, Uludag University) ;
  • Eminler, Ahmet Tarik (Department of Gastroenterology, School of Medicine, Uludag University) ;
  • Yerci, Omer (Department of Pathology, School of Medicine, Uludag University)
  • Published : 2014.10.23

Abstract

Introduction: Recent studies have indicated that down-regulation of the suppressor of cytokine signaling-1 (SOCS-1) gene results in tumor formation and that SOCS-1 acts as a tumor suppressor gene. SOCS-1 has been also suggested to function as a tumor suppressor with colorectal cancer. Objectives: In the present study, we aimed to determine the association of SOCS-1 expression in colorectal cancer tissues with clinicopathologic characteristics immunohistochemically and also to identify its prognostic significance. Materials and Methods: SOCS-1 expression was studied immunohistochemically in 67 patients diagnosed with resected colorectal carcinomas and 30 control subjects. Results: SOCS-1 expression was found in 46.3% of tumor tissues and 46.7% of the control group. Statistical analyses did not establish any significant association between SOCS-1 expression and clinicopathologic characteristics. Also, no significant association with SOCS-1 expression was found using progression-free survival and overall survival analyses (p=0.326 and p=0.360, respectively). Conclusions: Our results show that SOCS-1 has no prognostic significance in colorectal cancer.

Keywords

Colorectal carcinoma;methylation;suppressor of cytokine signaling-1;tumour suppressor

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