Clinical Applicability of Multi-Tumor Marker Protein Chips for Diagnosing Ovarian Cancer

  • Bian, Jing (Department of Laboratory The First Affiliated Hospital of Zhengzhou University) ;
  • Li, Bo (The Stem Cell Research Center, Medical College of Zhengzhou University) ;
  • Kou, Xian-Juan (College of Health Science, Wuhan Sports University) ;
  • Wang, Xu-Na (Department of Laboratory The First Affiliated Hospital of Zhengzhou University) ;
  • Sun, Xiao-Xu (Department of Laboratory The First Affiliated Hospital of Zhengzhou University) ;
  • Ming, Liang (Department of Laboratory The First Affiliated Hospital of Zhengzhou University)
  • Published : 2014.10.23


Purpose: To assess the value of multi-tumor marker protein chips in the diagnosis and treatment of ovarian cancer. Materials and Methods: Twelve tumor markers (CA19-9, NSE, CEA, CA242, CK19, ${\beta}$-HCG, AFP, SCC, c-PSA, CA125, CA724 and CA15-3) were detected by protein biochip in 220 patients with ovarian carcinomas, 205 with benign ovarian tumors and 200 healthy subjects. Results: The positivity rate was obviously higher in ovarian cancer (77.7%), than that in the benign cases (26.3%, p<0.01) and healthy subjects (4.5%, p<0.01). Serum levels of tumor markers were furthermore significantly higher in cases with lymph node metastasis (86.8%) than those without metastasis (44.7%), p<0.01. Conclusions: Multi-tumor marker protein chips provide important assistance in the diagnosis and treatment evaluation in ovarian cancers.


Protein chip;tumor markers;ovarian cancers;treatment evaluation


Supported by : Zhengzhou University


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