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Association of CYP2C19 Polymorphisms with Survival of Breast Cancer Patients Using Tamoxifen: Results of a Meta-analysis

  • Bai, Lan (Department of Pharmacy, Kunming General Hospital of Chengdu Military Command) ;
  • He, Juan (Department of Pharmacy, Kunming General Hospital of Chengdu Military Command) ;
  • He, Gong-Hao (Department of Pharmacy, Kunming General Hospital of Chengdu Military Command) ;
  • He, Jian-Chang (Department of Pharmacy, Kunming General Hospital of Chengdu Military Command) ;
  • Xu, Fan (Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region) ;
  • Xu, Gui-Li (Department of Pharmacy, Kunming General Hospital of Chengdu Military Command)
  • Published : 2014.10.23

Abstract

Background: Previous studies accessing the association of CYP2C19 with outcomes of patients using tamoxifen for breast cancer have yielded conflicting results. The aim of this meta-analysis is to obtain a more precise estimate of effects of CYP2C19 polymorphisms and to clarify their effects on survival of the breast cancer patients using tamoxifen. Materials and Methods: A systematic search of PubMed and Embase was performed, comparing patients with or without $CYP2C19^*2$ and $CYP2C19^*17$, relevant articles searched for. The following outcomes were included from the eligible studies: disease-free survival (DFS) and overall survival (OS), expressed by hazard ratios (HR) with corresponding 95% confidence interval (CI). Subgroup analysis by genotypes was also performed. Pooled estimates were calculated using random-effect model in accordance to the heterogeneity. Results: Six studies met the inclusion criteria. The integrated OR on the association between CYP2C19 and DFS, calculated by the random-effect model, was 0.54 (95%CI=0.34-0.84, p=0.013). Subgroup analysis showed that both $CYP2C19^*2$ and $CYP2C19^*17$ were associated with increased survival. The pooled results of two studies for OS were OR=0.46 (95%CI=0.21-1.01, p=0.233). Conclusions: This meta-analysis suggests that the $CYP2C19^*2$ and $CYP2C19^*17$ genotypes are associated with increased survival in breast cancer patients using tamoxifen.

Keywords

Breast cancer;$CYP2C19^*2$;$CYP2C19^*17$;survival;tamoxifen;meta-analysis

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