- Volume 15 Issue 19
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Meta Analysis of Association of the IL-17F rs763780T>C Gene Polymorphism with Cancer Risk
- Chen, Xiang-Jun (Department of Medical Quality Control, West China Hospital, Sichuan University) ;
- Zhou, Tao-You (Department of Infectious Disease, West China Hospital, Sichuan University) ;
- Chen, Min (Department of Medical Quality Control, West China Hospital, Sichuan University) ;
- Pu, Dan (Clinical Skill Experiment Teaching Center, West China Hospital, Sichuan University)
- Published : 2014.10.23
Purpose: To investigate the association of IL-17F rs763780T>C with cancer risk. Materials and Methods: We searched the Cochrane Central Library, PubMed, MEDLINE, EMBASE, CNKI (China National Knowledge Infrastructure) and WangFang databases until May 2014 for a meta-analysis conducted using RevMan 5.2 software. Results: A total of ten papers were included into this meta analysis, involving 3, 336 cases and 4, 217 healthy people. There were no significant differences on association of IL-17F rs763780T>C polymorphism with cancer risk except in the CC vs TT genetic model. Although the the risk in the gastric cancer group is higher than that in control group, there were no significant differences on the association of IL-17F rs763780T>C polymorphism with other cancers. Conclusions: Our meta analysis reveal the IL-17A rs763780T>C gene polymorphism is involved in risk of gastric cancer but not other tumor types.
- Alexandrakis MG, Pappa CA, Miyakis S, et al (2006). Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma. Eur J Intern Med, 17, 412-6. https://doi.org/10.1016/j.ejim.2006.02.012
- Arisawa T, Tahara T, Shibata T, et al (2008). The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. J Clin Immunol, 28, 44-9. https://doi.org/10.1007/s10875-007-9125-8
- Bettelli E, Carrier Y, Gao W, et al (2006). Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 441, 235-8. https://doi.org/10.1038/nature04753
- Kawaguchi M, Adachi M, Oda N, et al (2004). IL-17 cytokine family. J Allergy Clin Immunol, 114, 1265-73. https://doi.org/10.1016/j.jaci.2004.10.019
- Bondy ML, Scheurer ME, Malmer B, et al (2008). Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer, 113, 1953-68. https://doi.org/10.1002/cncr.23741
- Kaabachi W, ben Amor A, Kaabachi S, et al (2014). Interleukin-17A and -17F genes polymorphisms in lung cancer. Cytokine, 66, 23-9. https://doi.org/10.1016/j.cyto.2013.12.012
- Kato T, Furumoto H, Ogura T, et al (2001). Expression of IL-17 mRNA in ovarian cancer. Biochem Biophys Res Commun, 282, 735-8. https://doi.org/10.1006/bbrc.2001.4618
- Kawaguchi M, Takahashi D, Hizawa N, et al (2006). IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. J Allergy Clin Immunol, 117, 795-801. https://doi.org/10.1016/j.jaci.2005.12.1346
- Kolls JK, Linden A (2004). Interleukin-17 family members and inflammation. Immunity, 21, 467-76. https://doi.org/10.1016/j.immuni.2004.08.018
- Korn T, Bettelli E, Oukka M, et al (2009). IL-17 and Th17 Cells. Annu Rev Immunol, 27, 485-517. https://doi.org/10.1146/annurev.immunol.021908.132710
- Omrane I, Baroudi O, Bougatef K, et al (2014). Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer. Immunol Lett, 158, 189-94. https://doi.org/10.1016/j.imlet.2014.01.002
- Qin LY, Zhao LG, Chen X, et al (2014). The CCND1 G870A gene polymorphism and brain tumor risk: a meta-analysis. Asian Pac J Cancer Prev, 15, 3607-12. https://doi.org/10.7314/APJCP.2014.15.8.3607
- Quan Y, Zhou B, Wang Y, et al (2012). Association between IL17 polymorphisms and risk of cervical cancer in Chinese women. Clin Dev Immunol, 2012, 258293.
- Ramsey CD, Lazarus R, Camargo CA Jr, et al (2005). Polymorphisms in the interleukin 17F gene (IL17F) and asthma. Genes Immun, 6, 236-41. https://doi.org/10.1038/sj.gene.6364170
- Xu S, Cao X (2010). Interleukin-17 and its expanding biological functions. Cell Mol Immunol, 7, 164-74. https://doi.org/10.1038/cmi.2010.21
- Shibata T, Tahara T, Hirata I, et al (2009). Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. Hum Immunol, 70, 547-51. https://doi.org/10.1016/j.humimm.2009.04.030
- Wang L, Jiang Y, Zhang Y, et al (2012). Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. PLoS On, 7, 34400. https://doi.org/10.1371/journal.pone.0034400
- Wu X, Zeng Z, Chen B, et al (2010). Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. Int J Cancer, 127, 86-92. https://doi.org/10.1002/ijc.25027
- Yang Ruan, Yuezi Hu, Ke Tao, et al (2013). Association analysis of IL-17A and IL-17F gene polymorphisms with epithelial ovarian cancer. J Human Normal Univ, 9, 21-4.
- Zhang B, Rong G, Wei H, et al (2008). The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun, 374, 533-7. https://doi.org/10.1016/j.bbrc.2008.07.060
- Zhang X, Zheng L, Sun Y, et al (2014). Analysis of the association of interleukin-17 gene polymorphisms with gastric cancer risk and interaction with Helicobacter pylori infection in a Chinese population. Tumour Biol, 35, 1575-80. https://doi.org/10.1007/s13277-013-1217-x
- Zhou B, Zhang P, Wang Y, et al (2013). Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population. Mol Carcinog, 52, 871-8. https://doi.org/10.1002/mc.21928
- Zhu QH, Wang YY, Chen YF, et al (2014). Effect of interleukin-17A and interleukin-17F gene polymorphisms on the risk of gastric cancer in a Chinese population. Gene, 537, 328-32. https://doi.org/10.1016/j.gene.2013.11.007
- Zhu X, Mulcahy LA, Mohammed RA, et al (2008). IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines. Breast Cancer Res, 10, 95.