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Acute Oral Toxicity Study of Ethanol Extract of Curcuma longa L. in Mice

마우스에서 울금 에탄올 추출물의 단회 경구투여 독성에 관한 연구

  • Kim, Soo-Hwan (Department of Integrated Biomedical and Life Science, Graduate School, Korea University) ;
  • Lee, Hyeong-Seon (Department of Biomedical Laboratory Science, Jungwon University)
  • 김수환 (고려대학교 일반대학원 의생명융합과학과) ;
  • 이형선 (중원대학교 의료보건대학 임상병리학과)
  • Received : 2014.08.18
  • Accepted : 2014.10.14
  • Published : 2014.10.30

Abstract

A yellow-colored pigment is found in turmeric, or Curcuma longa L. (Zingiberaceae), a perennial herb distributed mainly throughout tropical and subtropical regions. C. longa has potent antiviral, antimutagenic, anti-inflammatory, anticancer, and antioxidant properties. However, pharmacological mechanisms of ethanol extract derived from C. longa remain poorly understood. The aim of this study was to investigate the potential acute toxicity of C. longa (Curcuma longa L.) extract in BALB/c mice administered a single oral dose of 0, 20, 200, and 2,000 mg/kg by gavage. After the administration of the agent, signs of toxicity were observed every hour for the first 6 hr and every day for 14 days. No mortality, abnormal clinical signs, or pathological changes were observed compared to a control group, and there were no differences in the body weights of the control and treatment groups. Biological serum activities were not significantly changed in the treatment group compared to the control group. These results indicate that a single oral administration of C. longa extract does not exert any toxic effects at a dose of 2,000 mg/kg body weight and that the $LD_{50}$ of C. longa extract is greater than 2,000 mg/kg body weight. Accordingly, C. longa appears to have potential in various functional agents or foods, without toxicity.

Keywords

Acute toxicity;BALB/c mice;Curcuma longa L.;$LD_{50}$;single oral

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