- Volume 15 Issue 18
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Association of rs1219648 in FGFR2 and rs1042522 in TP53 with Premenopausal Breast Cancer in an Iranian Azeri Population
- Saadatian, Zahra (International Branch of Tabriz University of Medical Sciences (Aras)) ;
- Gharesouran, Jalal (Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences) ;
- Ghojazadeh, Morteza (Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences) ;
- Ghohari-Lasaki, Sahar (Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences) ;
- Tarkesh-Esfahani, Najime (Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences) ;
- Ardebili, Seyyed Mojtaba Mohaddes (International Branch of Tabriz University of Medical Sciences (Aras))
- Published : 2014.10.11
Breast cancer is the most common cancer among women in the world. In Iran, the incidence of breast cancer is on the increase. We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in development of early onset sporadic breast cancer in Iranian Azeri population to evaluate epistatic effects on the risk of mammary neoplasia. We genotyped the two polymorphisms in 100 women with early onset breast cancer and 100 healthy women by PCR-RFLP. Allele frequency differences were tested using
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