DOI QR코드

DOI QR Code

Cervical Pathology in Cytology-Negative/HPV-Positive Women: Results from Lampang Cancer Hospital, Thailand

  • Paengchit, Kannika (Lampang Cancer Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Kietpeerakool, Chumnan (Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University) ;
  • Wangchai, Warunee (Lampang Cancer Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Pouraeng, Saifon (Lampang Cancer Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Lalitwongsa, Somkiet (Lampang Cancer Hospital, Faculty of Medicine, Khon Kaen University)
  • Published : 2014.10.11

Abstract

Background: To evaluate the cervical pathology of cytology-negative/high-risk human papillomavirus (HR-HPV) positive-women. Materials and Methods: This study recruited 4,583 women aged 30-70 years who had undergone cervical screening by liquid-based cytology and HR-HPV test (14 HR-HPV types) at Lampang Cancer Hospital during October 2012 to July 2013. Colposcopy was carried out in all women. Results: One hundred and ninety-two (4.19%) women were found to be cytology-negative/HR-HPV-positive. However, 23 cases were excluded because of incomplete information, leaving 169 women for further analyses. Of these 169, 45 (26.6%) were infected with HPV 16/18 and 49 (29.0%) with multiple genotypes of HR-HPV. Nineteen of 169 (11.24%) women were found to have CIN 2-3. No women in the present study had AIS or invasive cervical lesions. Prevalence of CIN 2-3 among women infected with HPV 16/18 was 15.6% which was higher than the 9.68% in those with non-HPV 16/18 oncogenic types. Conclusions: Overall, 11% of cytology-negative/HR-HPV-positive women had significant cervical lesions. Risk of harboring such lesions was substantially increased among those who were HPV 16/18 positive.

References

  1. Cox JT, Castle PE, Behrens CM, et al (2013). Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing, and genotyping for HPV 16/18: results from the ATHENA HPV study. Am J Obstet Gynecol, 208, 181-4. https://doi.org/10.1016/j.ajog.2012.07.034
  2. ASCUS-LSIL Traige Study (ALTS) Group (2003). A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations. Am J Obstet Gynecol, 188, 1393-400. https://doi.org/10.1016/S0002-9378(03)00413-7
  3. Chansaenroj J, Lurchachaiwong W, Termrungruanglert W, et al (2010). Prevalence and genotypes of human papillomavirus among Thai women. Asian Pac J Cancer Prev, 11, 117-22.
  4. Khan MJ, Castle PE, Lorincz AT, et al (2005). The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. J Natl Cancer Inst, 97, 1072-9. https://doi.org/10.1093/jnci/dji187
  5. Kietpeerakool C, Manopunya M, Phuprasertsak P, et al (2011). An audit of colposcopy appointment processes in women with abnormal cervical cytology. Cytopathology, 22, 184-8.
  6. Kim K, Kim JJ, Kim SM, et al (2012). Prevalence and determinants of high-risk human papillomavirus infection in women with high socioeconomic status in Seoul, Republic of Korea. Asian Pac J Cancer Prev, 13, 269-73. https://doi.org/10.7314/APJCP.2012.13.1.269
  7. Kitchener HC, Almonte M, Thomson C, et al (2009). HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial. Lancet Oncol, 10, 672-82. https://doi.org/10.1016/S1470-2045(09)70156-1
  8. Rattanalappaiboon D, Kietpeerakool C, Kleebkaow P, et al (2014). Factors affecting compliance in the first year of postcolposcopy surveillance among women with a high incidence of cervical cancer. Int J Gynaecol Obstet, 124, 160-3. https://doi.org/10.1016/j.ijgo.2013.07.026
  9. Leinonen M, Nieminen P, Kotaniemi-Talonen L, et al (2009). Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting. J Natl Cancer Inst, 101, 1612-23. https://doi.org/10.1093/jnci/djp367
  10. Massad LS, Einstein MH, Huh WK, et al (2013). 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. Obstet Gynecol, 121, 829-46. https://doi.org/10.1097/AOG.0b013e3182883a34
  11. Moore MA, Attasara P, Khuhaprema T, et al (2010). Cancer epidemiology in mainland South-East Asia-past, present and future. Asian Pac J Cancer Prev, 11, 67-80.
  12. Rijkaart DC, Berkhof J, Rozendaal L, et al (2012). Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial. Lancet Oncol, 13, 78-88. https://doi.org/10.1016/S1470-2045(11)70296-0
  13. Ronco G, Giorgi-Rossi P, Carozzi F, et al (2010). Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial. Lancet Oncol, 11, 249-57. https://doi.org/10.1016/S1470-2045(09)70360-2
  14. Siriaree S, Srisomboon J, Kietpeerakool C, et al (2006). Highgrade squamous intraepithelial lesion with endocervical cone margin involvement after cervical loop electrosurgical excision: what should a clinician do? Asian Pac J Cancer Prev, 7, 463-6.
  15. Sui S, Jiao Z, Niyazi M, et al (2013). Genotype distribution and behavioral risk factor analysis of human papillomavirus infection in Uyghur women. Asian Pac J Cancer Prev, 14, 5861-5. https://doi.org/10.7314/APJCP.2013.14.10.5861
  16. Swangvaree SS, Kongkaew P, Rugsuj P, et al (2010). Prevalence of high-risk human papillomavirus infection and cytologic results in Thailand. Asian Pac J Cancer Prev, 11, 1465-8.
  17. Wright TC Jr, Stoler MH, Sharma A, et al (2011). Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+cytology-negative results. Am J Clin Pathol, 136, 578-86. https://doi.org/10.1309/AJCPTUS5EXAS6DKZ

Cited by

  1. Histologic Outcomes in HPV-Positive and Cervical Cytology-Negative Women - Screening Results in Northern Thailand vol.16, pp.16, 2015, https://doi.org/10.7314/APJCP.2015.16.16.7271
  2. Prevalence of Human Papillomavirus Types and Phylogenetic Analysis of HPV-16 L1 Variants from Southern India vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.2073
  3. Level of Knowledge and Behavior of Family Health Personnel Workers in Izmir about Early Diagnosis for Breast and Cervix Cancer vol.16, pp.6, 2015, https://doi.org/10.7314/APJCP.2015.16.6.2501
  4. Can the careHPV test performed in mobile units replace cytology for screening in rural and remote areas? vol.124, pp.8, 2016, https://doi.org/10.1002/cncy.21718
  5. High-grade Cervical Histopathology in Women with Atypical Glandular Cell Cytology vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.135