- Volume 15 Issue 18
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The Neutrophil to Lymphocyte Ratio has a High Negative Predictive Value for Pathologic Complete Response in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
- Eryilmaz, Melek Karakurt (Department of Medical Oncology, Akdeniz University School of Medicine) ;
- Mutlu, Hasan (Department of Medical Oncology, Akdeniz University School of Medicine) ;
- Salim, Derya Kivrak (Department of Medical Oncology, Akdeniz University School of Medicine) ;
- Musri, Fatma Yalcin (Department of Medical Oncology, Akdeniz University School of Medicine) ;
- Tural, Deniz (Department of Medical Oncology, Akdeniz University School of Medicine) ;
- Coskun, Hasan Senol (Department of Medical Oncology, Akdeniz University School of Medicine)
- Published : 2014.10.11
Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with pancreatic, colorectal, lung, gastric cancer and renal cell carcinoma. The aim of this study was to determine the relationship between pathological complete response (pCR) and pretreatment NLR values in locally advanced breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Materials and Methods: Datawere collected retrospectively from the Akdeniz University School of Medicine Database for locally advanced BC patients treated with NACT between January 2000-December 2013. Results: A total of 78 patients were analyzed. Sixteen (20%) patients achieved pCR. Estrogen receptor (ER) positivity was lower in pCR+ than pCR-cases (p=0.011). The median NLR values were similar in both arms. The optimum NLR cut-off point for BC patients with PCR+ was 2.33 (AUC:0.544, 95%CI [0.401-0.688], p=0.586) with sensitivity, specificity, positive predictive value and negative predictive value (NPV) of 50%, 51,6%, 21,1%, and 80%, respectively. Conclusions: This study showed no relationship between the pCR and pretreatment NLR values. Because of a considerable high NPV, in the patients with higher NLR who had luminal type BC in which pCR is lower after NACT, such treatment may not be recommended.
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- Diagnostic and Prognostic Importance of the Neutrophil Lymphocyte Ratio in Breast Cancer vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10363
- Preoperative Neutrophil to Lymphocyte Ratio as a Prognostic Factor in Patients with Non-metastatic Renal Cell Carcinoma vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3703
- Pretreatment neutrophil-to-lymphocyte ratio is correlated with response to neoadjuvant chemotherapy as an independent prognostic indicator in breast cancer patients: a retrospective study vol.16, pp.1, 2016, https://doi.org/10.1186/s12885-016-2352-8
- Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer vol.17, pp.4, 2016, https://doi.org/10.7314/APJCP.2016.17.4.2089
- Association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with ER and PR in breast cancer patients and their changes after neoadjuvant chemotherapy vol.19, pp.8, 2017, https://doi.org/10.1007/s12094-017-1630-5
- The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer vol.18, pp.1, 2018, https://doi.org/10.1186/s12885-018-4832-5
- Prognostic role of high neutrophil-to-lymphocyte ratio in breast cancer patients receiving neoadjuvant chemotherapy vol.98, pp.1, 2019, https://doi.org/10.1097/MD.0000000000013842