DOI QR코드

DOI QR Code

Body Mass Index Effects on Risk of Ovarian Cancer: A Meta-Analysis

  • Poorolajal, Jalal (Modeling of Noncommunicable Diseases Research Center, Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences) ;
  • Jenabi, Ensiyeh (Department of Midwifery, Toyserkan Branch, Islamic Azad University) ;
  • Masoumi, Seyyedeh Zahra (Mother and Child Care Research Center, Department of Midwifery, School of Nursing and Midwifery, Hamadan University of Medical Sciences)
  • Published : 2014.10.11

Abstract

Objectives: The association between body mass index (BMI) and ovarian cancer risk is unclear and requires further investigation. The present meta-analysis was conducted to assess the effect of overweight and obesity on ovarian cancer risk in the premenopausal and postmenopausal periods. Data sources: Major electronic databases were searched until February 2014 including Medline and Scopus. Reference lists and relevant conference databases were searched and the authors were contacted for additional unpublished references. Review Methods: All cohort and case-control studies addressing the effect of BMI on ovarian cancer were included, irrespective of publication date and language. The effect measure of choice was risk ratio (RR) for cohort studies and odds ratio (OR) for case-control studies. The results were reported using a random effects model with 95% confidence intervals (CIs). Results: Of 3,776 retrieved studies, 19 were ultimately analyzed including 10 cohort studies involving 29,237,219 person-years and 9 case-control studies involving 96,965 people. The results of both cohort and case-control studies showed being overweight and obesity increased the risk of ovarian cancer compared to women with normal weight during both premenopausal and postmenopausal periods: RR=1.08 (95%CI: 0.97, 1.19) and OR=1.26 (95%CI: 0.97, 1.63) for overweight and RR=1.27 (95%CI: 1.16, 1.38) and OR=1.26 (95%CI: 1.06, 1.50) for obesity. Conclusions: There is sufficient evidence that an increase in BMI can increase the risk of ovarian cancer regardless of the menopausal status, mimicking a dose-response relationship although the association is not very strong.

References

  1. Acmaz G, Aksoy H, Albayrak E, et al (2014). Evaluation of endometrial precancerous lesions in postmenopausal obese women--a high risk group? Asian Pac J Cancer Prev, 15, 195-8. https://doi.org/10.7314/APJCP.2014.15.1.195
  2. Alegre MM, Knowles M, Robison RA, et al (2013). Mechanics behind breast cancer prevention-focus on obesity, exercise and dietary fat. Asian Pac J Cancer Prev, 14, 2207-12. https://doi.org/10.7314/APJCP.2013.14.4.2207
  3. Anderson JP, Ross JA, Folsom AR (2004). Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa Women's Health Study. Cancer, 100, 1515-21. https://doi.org/10.1002/cncr.20146
  4. Bandera EV (2007). Nutritional factors in ovarian cancer prevention: What have we learned in the past 5 years? Nutr Cancer, 59, 142-51. https://doi.org/10.1080/01635580701458160
  5. Beehler GP, Sekhon M, Baker JA, et al (2006). Risk of ovarian cancer associated with BMI varies by menopausal status. J Nutr, 136, 2881-6.
  6. Begg CB, Mazumdar M (1994). Operating characteristics of a rank cor relation test for publication bias. Biometrics, 50, 1088-101. https://doi.org/10.2307/2533446
  7. Collaborative Group on Epidemiological Studies of Ovarian Cancer (2012). Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Med, 9, 1001200. https://doi.org/10.1371/journal.pmed.1001200
  8. Brinton LA, Lamb EJ, Moghissi KS, et al (2004). Ovarian cancer risk associated with varying causes of infertility. Fertility and Sterility, 82, 405-14. https://doi.org/10.1016/j.fertnstert.2004.02.109
  9. Cheraghi Z, Poorolajal J, Hashem T, et al (2012). Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis. PloS one, 7, 51446. https://doi.org/10.1371/journal.pone.0051446
  10. Chionh F, Baglietto L, Krishnan K, et al (2010). Physical activity, body size and composition, and risk of ovarian cancer. Cancer Causes Control, 21, 2183-94. https://doi.org/10.1007/s10552-010-9638-y
  11. Delort L, Kwiatkowski F, Chalabi N, et al (2009). Central adiposity as a major risk factor of ovarian cancer. Anticancer Res, 29, 5229-34.
  12. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  13. Egger M, Davey SG, Schneider M, et al (1997). Bias in metaanalysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  14. Engeland A, Tretli S, Bjørge T (2003). Height, body mass index, and ovarian cancer: A follow-up of 1.1 million Norweigian women. J Natl Cancer Inst, 95, 1244-8. https://doi.org/10.1093/jnci/djg010
  15. Gulcelik MA, Colakoglu K, Dincer H, et al (2012). Associations between adiponectin and two different cancers: breast and colon. Asian Pac J Cancer Prev, 13, 395-8. https://doi.org/10.7314/APJCP.2012.13.1.395
  16. Higgins JPT, Thompson SG, Deeks JJ, et al (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60. https://doi.org/10.1136/bmj.327.7414.557
  17. Joshi RK, Lee SA (2014). Obesity related adipokines and colorectal cancer: a review and meta-analysis. Asian Pac J Cancer Prev, 15, 397-405. https://doi.org/10.7314/APJCP.2014.15.1.397
  18. Lacey Jr JV, Leitzmann M, Brinton LA, et al (2006). Weight, height, and body mass index and risk for ovarian cancer in a cohort study. Ann Epidemiol, 16, 869-76. https://doi.org/10.1016/j.annepidem.2006.07.011
  19. Kaneko R, Nakazaki N, Tagawa T, et al (2014). A new index of abdominal obesity which effectively predicts risk of colon tumor development in female Japanese. Asian Pac J Cancer Prev, 15, 1005-10. https://doi.org/10.7314/APJCP.2014.15.2.1005
  20. Kotsopoulos J, Baer HJ, Tworoger SS (2010). Anthropometric measures and risk of epithelial ovarian cancer: Results from the nurses' health study. Obesity, 18, 1625-31. https://doi.org/10.1038/oby.2009.461
  21. Kuper H, Cramer DW, Titus-Ernstoff L (2002). Risk of ovarian cancer in the United States in relation to anthropometric measures: does the association depend on menopausal status? Cancer Causes Control, 13, 455-63. https://doi.org/10.1023/A:1015751105039
  22. Lahmann PH, Cust AE, Friedenreich CM, et al (2010). Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer, 126, 2404-15.
  23. Lawlor DA, Bedford C, Taylor M, et al (2002). Agreement between measured and self reported weight in older women. Results from the British Women's Heart and Health Study. Age Ageing, 31, 169-74. https://doi.org/10.1093/ageing/31.3.169
  24. Leitzmann MF, Koebnick C, Danforth KN, et al (2009). Body mass index and risk of ovarian cancer. Cancer, 115, 812-22. https://doi.org/10.1002/cncr.24086
  25. Lukanova A, Bjor O, Kaaks R, et al (2006). Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort. Int J Cancer, 118, 458-66. https://doi.org/10.1002/ijc.21354
  26. Minatoya M, Kutomi G, Asakura S, et al (2013). Equol, adiponectin, insulin levels and risk of breast cancer. Asian Pac J Cancer Prev, 14, 2191-9. https://doi.org/10.7314/APJCP.2013.14.4.2191
  27. Moorman PG, Palmieri RT, Akushevich L, et al (2009). Ovarian cancer risk factors in African-American and white women. Am J Epidemiol, 170, 598-606. https://doi.org/10.1093/aje/kwp176
  28. Olsen CM, Nagle CM, Whiteman DC, et al (2008). Body size and risk of epithelial ovarian and related cancers: a populationbased case-control study. Int J Cancer, 123, 450-6. https://doi.org/10.1002/ijc.23509
  29. Nagle CM, Olsen CM, Webb PM, et al (2008). Endometrioid and clear cell ovarian cancers - A comparative analysis of risk factors. Eur J Cancer, 44, 2477-84. https://doi.org/10.1016/j.ejca.2008.07.009
  30. Niwa Y, Yatsuya H, Tamakoshi K, et al (2005). Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. J Obstet Gynaecol Res, 31, 452-8. https://doi.org/10.1111/j.1447-0756.2005.00319.x
  31. Olsen CM, Green AC, Whiteman DC, et al (2007). Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer, 43, 690-709. https://doi.org/10.1016/j.ejca.2006.11.010
  32. Organization WH 2000. Obesity: preventing and managing the global epidemic, World Health Organization.
  33. Permuth-Wey J, Sellers TA (2009). Epidemiology of ovarian cancer. In 'Cancer Epidemiology', Eds Springer, 413-37
  34. Peterson NB, Trentham-Dietz A, Newcomb PA, et al (2006). Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States). Cancer Causes Control, 17, 459-67. https://doi.org/10.1007/s10552-005-0416-1
  35. Purdie DM, Bain CJ, Webb PM, et al (2001). Body size and ovarian cancer: case-control study and systematic review (Australia). Cancer Causes Control, 12, 855-63. https://doi.org/10.1023/A:1012267619561
  36. Riman T, Dickman PW, Nilsson S, et al (2001). Risk factors for epithelial borderline ovarian tumors: results of a Swedish case-control study. Gynecol Oncol, 83, 575-85. https://doi.org/10.1006/gyno.2001.6451
  37. Sangrajrang S, Chaiwerawattana A, Ploysawang P, et al (2013). Obesity, diet and physical inactivity and risk of breast cancer in Thai women. Asian Pac J Cancer Prev, 14, 7023-7. https://doi.org/10.7314/APJCP.2013.14.11.7023
  38. Weiderpass E, Sandin S, Inoue M, et al (2012). Risk factors for epithelial ovarian cancer in Japan - results from the Japan Public Health Center-based Prospective Study cohort. Int J Oncol, 40, 21-30.
  39. Schouten LJ, Goldbohm RA, van den Brandt PA (2003). Height, weight, weight change, and ovarian cancer risk in the Netherlands cohort study on diet and cancer. Am J Epidemiol, 157, 424-33. https://doi.org/10.1093/aje/kwf224
  40. Schouten LJ, Rivera C, Hunter DJ, et al (2008). Height, body mass index, and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomarkers Prev, 17, 902-12. https://doi.org/10.1158/1055-9965.EPI-07-2524
  41. Taylor AW, Grande ED, Gill TK, et al (2006). How valid are self reported height and weight? A comparison between CATI self report and clinic measurements using a large cohort study. Aust New Zealand J Public Health, 30, 238-46. https://doi.org/10.1111/j.1467-842X.2006.tb00864.x
  42. Wells GA SB, O'Connell D, Peterson J, et al (2009). The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. PLoS Negl Trop Dis, 7, e2195.
  43. Wells GA, Shea B, O'Connell D, et al 2009. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Online]. Ontario: Ottawa Hospital Research Institute.
  44. Wernli KJ, Newcomb PA, Hampton JM, et al (2008). Hormone therapy and ovarian cancer: incidence and survival. Cancer Causes Control, 19, 605-13. https://doi.org/10.1007/s10552-008-9125-x
  45. World Health Organisation 1996. Research on the Menopause in the 1990's. technical report series 866, Geneva, WHO.
  46. World Health Organization 2000. International classification of disease for oncology, Geneva, WHO.

Cited by

  1. pathway is associated with Advanced Ovarian Cancer in Saudi Patients vol.16, pp.14, 2015, https://doi.org/10.7314/APJCP.2015.16.14.5807
  2. Reproductive factors, adiposity, breastfeeding and their associations with ovarian cancer in an Asian cohort vol.26, pp.11, 2015, https://doi.org/10.1007/s10552-015-0649-6
  3. Substance use disorder and risk of suicidal ideation, suicide attempt and suicide death: a meta-analysis vol.38, pp.3, 2015, https://doi.org/10.1093/pubmed/fdv148
  4. The association between body mass index and preeclampsia: a meta-analysis vol.29, pp.22, 2016, https://doi.org/10.3109/14767058.2016.1140738
  5. Impact of body mass index on ovarian cancer survival varies by stage vol.117, pp.2, 2017, https://doi.org/10.1038/bjc.2017.162
  6. Proportion of cancer in a Middle eastern country attributable to established risk factors vol.17, pp.1, 2017, https://doi.org/10.1186/s12885-017-3304-7
  7. Prepregnancy obesity vol.26, pp.2, 2017, https://doi.org/10.1097/CEJ.0000000000000228
  8. Breast cancer screening (BCS) chart: a basic and preliminary model for making screening mammography more productive and efficient pp.1741-3850, 2017, https://doi.org/10.1093/pubmed/fdx052
  9. Obesity, weight gain, and ovarian cancer risk in African American women vol.139, pp.3, 2016, https://doi.org/10.1002/ijc.30115