- Volume 15 Issue 18
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Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis
- Yu, Li-Xiang (Department of Breast Diseases, The Second Hospital of Shandong University) ;
- Zhou, Nan-Nan (Department of Aged Cardiovascular Diseases, Shandong Provincial Hospital Affiliated to Shandong University) ;
- Liu, Li-Yuan (Epidemiology Institute, School of Public Health, Shandong University) ;
- Wang, Fei (Department of Breast Diseases, The Second Hospital of Shandong University) ;
- Ma, Zhong-Bing (Department of Breast Diseases, The Second Hospital of Shandong University) ;
- Li, Jie (Nursing Psychology, School of Nursing, Shandong University) ;
- Yu, Zhi-Gang (Department of Breast Diseases, The Second Hospital of Shandong University)
- Published : 2014.10.11
Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95%CI: 1.21-1.70; G carriers vs A carriers, OR: 1.23, 95%CI: 1.11-1.36; dominant model, OR: 1.28, 95%CI: 1.10-1.49 and recessive model, OR: 1.31, 95%CI: 1.12-1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95%CI: 1.26-1.92; G carriers vs. A carriers OR: 1.30, 95%CI: 1.18-1.43; dominant model OR: 1.31, 95%CI: 1.08-1.60 and recessive model OR: 1.44, 95%CI: 1.26-1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.
Supported by : Shandong University
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