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Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

  • Yu, Li-Xiang (Department of Breast Diseases, The Second Hospital of Shandong University) ;
  • Zhou, Nan-Nan (Department of Aged Cardiovascular Diseases, Shandong Provincial Hospital Affiliated to Shandong University) ;
  • Liu, Li-Yuan (Epidemiology Institute, School of Public Health, Shandong University) ;
  • Wang, Fei (Department of Breast Diseases, The Second Hospital of Shandong University) ;
  • Ma, Zhong-Bing (Department of Breast Diseases, The Second Hospital of Shandong University) ;
  • Li, Jie (Nursing Psychology, School of Nursing, Shandong University) ;
  • Yu, Zhi-Gang (Department of Breast Diseases, The Second Hospital of Shandong University)
  • Published : 2014.10.11

Abstract

Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95%CI: 1.21-1.70; G carriers vs A carriers, OR: 1.23, 95%CI: 1.11-1.36; dominant model, OR: 1.28, 95%CI: 1.10-1.49 and recessive model, OR: 1.31, 95%CI: 1.12-1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95%CI: 1.26-1.92; G carriers vs. A carriers OR: 1.30, 95%CI: 1.18-1.43; dominant model OR: 1.31, 95%CI: 1.08-1.60 and recessive model OR: 1.44, 95%CI: 1.26-1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.

Acknowledgement

Supported by : Shandong University

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