Anti-Cancer Effect of Gallic Acid in CT-26 Cells Inoculated Cancer Bearing Balb/C Mice

CT-26 세포 암 유발 마우스에서 Gallic acid의 항암 효과

  • Lee, Jung Hee (Department of Beauty Science, Gwangju Women's University) ;
  • Choi, Hwa-Jung (Department of Beauty Science, Gwangju Women's University) ;
  • Kim, Pom-Ho (Department of Alternative Medicine of Graduate School of Welfare & Management, Namseoul University)
  • 이정희 (광주여자대학교 미용과학과) ;
  • 최화정 (광주여자대학교 미용과학과) ;
  • 김범호 (남서울대학교 복지경영대학원 대체치유학과)
  • Received : 2014.06.16
  • Accepted : 2014.10.10
  • Published : 2014.10.31


This study examined the anti-cancer activity of gallic acid(GA) isolated from P. suffruticosa. was analyzed by ESI-MS, $^1H$-NMR, and $^{13}C$-NMR. The anti-cancer activity was evaluated by measuring the cancer size in CT-26 cancer-allograft mice treated with GA(100 mg/kg p.o) for 14 days. The change in body weight, acute toxicity, weight change of the liver and spleen and biomaker of the liver were evaluated in the mice after the GA treatment. As a result, the cancer size of the CT-26 cancer-allograft mice treated with GA decreased significantly compared to that of the cancer mice without significant changes in weight loss (p<0.05) and acute toxicity. The weight of the liver and spleen and ALT, AST and LPO levels increased by cancer were decreased significantly after the GA treatment, and the GSH levels decreased by cancer were increased significantly with the GA treatment (p<0.05). Therefore, GA could be an attractive lead for the development of anticancer agents.


Anticancer agents;Biochemical markers;Gallic acid;Mice;Paeonia suffruticosa


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