DOI QR코드

DOI QR Code

Discovery of FAK Inhibitors Using Structure Based Drug Design

  • Nam, Ky-Youb ;
  • Jin, Dong-Hoon ;
  • No, Kyoung Tai ;
  • Ahn, Soon Kil
  • Received : 2014.06.27
  • Accepted : 2014.07.11
  • Published : 2014.11.20

Abstract

Keywords

Focal adhesion kinase 1;Kinase inhibitor;Anticancer drug;Quantum mechanical calculations;Structure-based drug design

References

  1. Schlaepfer, D. D.; Hauck, C. R.; Sieg, D. J. Prog. Biophys. Mol. Biol. 1999, 71, 435-478. https://doi.org/10.1016/S0079-6107(98)00052-2
  2. Mitra, S. K.; Hanson, D. A.; Schlaepfer, D. D. Nat. Rev. Mol. Cell Biol. 2005, 6, 56-68. https://doi.org/10.1038/nrm1549
  3. Parsons, J. T. J. Cell Sci. 2003, 116, 1409-1416. https://doi.org/10.1242/jcs.00373
  4. Cance, W. G.; Harris, J. E.; Iacocca, M. V.; Roche, E.; Yang, X.; Chang, J.; Simkins, S.; Xu, L. Clin. Cancer Res. 2000, 6, 2417-2423.
  5. Golubovskaya, V. M.; Conway-Dorsey, K.; Edmiston, S. N.; Tse, C. K.; Lark, A. A.; Livasy, C. A.; Moore, D.; Millikan, R. C.; Cance, W. G. Int. J. Cancer 2009, 125, 1735-1738. https://doi.org/10.1002/ijc.24486
  6. Roberts, W. G.; Ung, E.; Whalen, P.; Cooper, B.; Hulford, C.; Autry, C.; Richter, D.; Emerson, E.; Lin, J.; Kath, J.; Coleman, K.; Yao, L.; Martinez-Alsina, L.; Lorenzen, M.; Berliner, M.; Luzzio, M.; Patel, N.; Schmitt, E.; LaGreca, S.; Jani, J.; Wessel, M.; Marr, E.; Griffor, M.; Vajdos, F. Cancer Res. 2008, 68, 1935-1944. https://doi.org/10.1158/0008-5472.CAN-07-5155
  7. Lim, S.-T.; Chen, X. L.; Lim, Y.; Hanson, D. A.; Vo, T.-T.; Howerton, K.; Larocque, N.; Fisher, S. J.; Schlaepfer, D. D.; Ilic, D. Mol. Cell 2008, 29, 9-22. https://doi.org/10.1016/j.molcel.2007.11.031
  8. Study of a Focal Adhesion Kinase Inhibitor in Subjects With Solid Tumors. Available from: http://clinicaltrials.gov/show/NCT01138033
  9. Liu, T. J.; LaFortune, T.; Honda, T.; Ohmori, O.; Hatakeyama, S.; Meyer, T.; Jackson, D.; de Groot, J.; Yung, W. K. Mol. Cancer Ther. 2007, 4, 1357-1367.
  10. Honorio, K. M.; Moda, T. L.; Andricopulo, A. D. Med. Chem. 2013, 9, 163-176. https://doi.org/10.2174/1573406411309020002
  11. Fujiwara, S. J.; Yamashita, F.; Hashida, M. Int. J. Pharmaceut. 2002, 237, 95-105. https://doi.org/10.1016/S0378-5173(02)00045-5
  12. Kamlet, M. J.; Doherty, R. M.; Fiserova-Bergerova, V.; Carr, P. W.; Abraham, M. H.; Taft, R. W. J. Pharm. Sci. 1987, 76, 14-17. https://doi.org/10.1002/jps.2600760105
  13. Nam, K.-Y.; Choi, I.; Cho, K.-H. Bull. Korean Chem. Soc. 2011, 32, 1125-1126. https://doi.org/10.5012/bkcs.2011.32.4.1125
  14. Lietha, D.; Eck, M. J. PLoS ONE 2008, 3, e3800. https://doi.org/10.1371/journal.pone.0003800
  15. Berman, H. M.; Westbrook, J.; Feng, Z.; Gilliland, G.; Bhat, T. N.; Weissig, H.; Shindyalov, I. N.; Bourne, P. E. Nucleic. Acids Research 2000, 28, 235-242. https://doi.org/10.1093/nar/28.1.235
  16. Discovery Studio 3.0 of Accelrys Inc., San Diego, CA, http://www.accelrys.com.
  17. Frisch, M. J. et al. GAUSSIAN 03, Revision B2; Gaussian Inc.: Pittsburgh, PA, 2003.
  18. Bioinformatics & Molecular Design Research Center, Seoul, Korea, PreADMET, version 2.0. 2007; available at http://preadmet.bmdrc.org/

Cited by

  1. Novel focal adhesion kinase 1 inhibitor sensitizes lung cancer cells to radiation in a p53-independent manner vol.51, pp.5, 2017, https://doi.org/10.3892/ijo.2017.4141

Acknowledgement

Supported by : Incheon National University