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Stereocontrolled Dihydroxylation Reactions of Acyclic Allylic Amines

비고리 알릴아민 화합물의 입체선택적 이중알코올화 반응

  • Jeon, Jongho (Research Division for Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Shin, Nara (Department of Chemical and Biological Engineering, Seoul National University) ;
  • Kim, Young Gyu (Department of Chemical and Biological Engineering, Seoul National University)
  • 전종호 (한국원자력연구원 첨단방사선연구소 생명공학연구부) ;
  • 신나라 (서울대학교 공과대학 화학생물공학부) ;
  • 김영규 (서울대학교 공과대학 화학생물공학부)
  • Received : 2014.09.30
  • Published : 2014.10.10

Abstract

The dihydroxylation reaction of allylic amines is a facile and useful synthetic method to obtain amino diol structures that are widely found in lots of biologically important natural products. This review will focus on the recent methods of both substrate-controlled and ligand-controlled dihydroxylation reactions of acyclic allylic amines. In addition, several applications of the diastereoselective dihydroxylation methods to asymmetric syntheses of natural products are presented.

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