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Anti-inflammatory Effects of Korean red ginseng Extract in formalin-induced Orofacial Pain in Rats

포르말린으로 유도된 안면통증에 대한 홍삼추출물의 항염증 효과

  • Received : 2014.07.23
  • Accepted : 2014.09.11
  • Published : 2014.09.30

Abstract

The effects of korean red ginseng (KRG) extracts on orifacial pain control in terms of the systemic inflammatory response and pharmacological effects as health supplements were investigated. The experimental group were divided into three groups, the control group (n=6), formalin (5%, $50{\mu}{\ell}$) injection group (n=6), and formalin (5%, $50{\mu}{\ell}$) injection added KRG administrated group (4.5 ml/kg, n=6). The KRG administrated group prior to the formalin injection significantly attenuated the behavioral response compared to that of the control group. Pain reduction was suppressed mainly from 15 min to 30 min. The KRG administrated rats showed significantly reduced p38 MAPK, iNOS and Nrf2 expression in the brain and medulla oblongata according to Western blot analysis. These findings suggest that KRE may have a useful effect on orificial pain control functions by preventing the p38 MAPK pathway.

Keywords

Korean red ginseng extract;iNOS;Nrf2;Orofacial pain;p38 MAPK

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Acknowledgement

Supported by : 동의대학교