- Volume 15 Issue 14
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Processed Meat Consumption and Squamous Cell Carcinoma of the Oesophagus in a Large Case-Control Study in Uruguay
- Stefani, Eduardo De (Epidemiology Group, Department of Pathology, School of Medicine, University of the Republic) ;
- Boffetta, Paolo (The Tisch Cancer Institute, Mount Sinai School of Medicine) ;
- Ronco, Alvaro Luis (Department of Epidemiology, IUCLAEH School of Medicine) ;
- Deneo-Pellegrini, Hugo (Epidemiology Group, Department of Pathology, School of Medicine, University of the Republic) ;
- Correa, Pelayo (Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center) ;
- Acosta, Gisele (Epidemiology Group, Department of Pathology, School of Medicine, University of the Republic) ;
- Mendilaharsu, Maria (Epidemiology Group, Department of Pathology, School of Medicine, University of the Republic)
- Published : 2014.07.30
Background: The role of processed meat in the aetiology of squamous cell oesophageal cancer has been explored in detail. Methods: In the time period 1990-2005, a case-control study was conducted in Montevideo, Uruguay including 2,368 participants (876 cases of oesophageal cancer and 1,492 controls). Relative risks, approximated by the odds ratios, were estimated by multiple unconditional logistic regression. Results: Processed meat was positively associated with oesophageal cancer (upper quartile vs lower quartile OR 2.30, 95%CI 1.72-3.07), whereas salted meat intake was positively associated with squamous cell oesophageal cancer (OR 3.82, 95%CI 2.74-5.33). Finally other cured meats were positively associated with oesophageal cancer (OR 1.65, 95%CI 1.22-2.22). Conclusions: It could be concluded that processed meat consumption could be an important risk factor for the aetiology of squamous cell oesophageal cancer in Uruguay.
Squamous cell oesophageal cancer;processed meat;salted meat;other cured meats
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