DOI QR코드

DOI QR Code

Meat Consumption, Animal Products, and the Risk of Bladder Cancer: A Case-Control Study in Uruguayan Men

  • Ronco, Alvaro Luis ;
  • Mendilaharsu, Maria ;
  • Boffetta, Paolo ;
  • Deneo-Pellegrini, Hugo ;
  • Stefani, Eduardo De
  • Published : 2014.07.30

Abstract

In the time period 1996-2004, all incident cases of bladder cancer were included in a case-control study in order to study the role of meat consumption and product animals in the etiology of urothelial cancer. The study included 225 cases and 1,510 hospitalized controls with non-neoplastic conditions, not related to smoking and alcohol drinking. Relative risks, approximated by the odds ratios, were calculated in order to clarify the effect of meat consumption in the etiology of urothelial cancer. Total meat consumption (OR 1.47, 95% CI 1.02-2.11), total processed meat (OR 1.57, 95% CI 1.08-2.27), frankfurters (hot dogs) (OR 2.03, 95% CI 1.28-3.21), ham (OR 1.79, 95% CI 1.21-2.67) and salted meat (OR 2.73, 95% CI 1.78-4.18) were positively associated with risk of bladder cancer. Animal products, like cheese, whole milk, and total eggs were also associated with bladder cancer risk (OR for eggs 4.05, 95% CI 2.68-6.12). In conclusion, total meat, processed meat, and eggs could play an important role in the etiology of bladder cancer in Uruguay.

Keywords

Bladder cancer;meat consumption;red meat;processed meat;eggs;cholesterol;Uruguay

References

  1. Aune D, De Stefani E, Ronco AL, et al (2009a). Meat consumption and cancer risk: a case-control study in Uruguay. Asian Pac J Cancer Prev, 10, 429-436.
  2. Aune D, Ronco A, Boffetta P, et al (2009b). Meat consumption and cancer risk: a multisite case-control study in Uruguay. Cancer Therapy, 7, 174-187.
  3. Aune D, De Stefani E, Ronco AL, et al (2009c). Egg consumption and risk of cancer: a multisite case-control study in Uruguay. Asian Pac J Cancer Prev, 10, 869-876.
  4. Balbi JC, Larrinaga MT, De Stefani E, et al (2001). Food and risk of bladder cancer: a case-control study in Uruguay. Eur J Cancer Prev, 10, 453-458. https://doi.org/10.1097/00008469-200110000-00009
  5. Barrios E, Vassallo JA, Alonso R, et al (2010). III Atlas of Cancer Incidence in Uruguay 2002-2006. National Cancer Registry, Honorary Commission of Fight Against Cancer, Uruguay, (In Spanish).
  6. Brennan P, Fortes C, Butler J, et al (2000). A multicenter casecontrol study of diet and lung cancer among non-smokers. Cancer Causes Control, 11, 49-58. https://doi.org/10.1023/A:1008909519435
  7. Castelao JE, Yuan JM, Gago-Dominguez M, et al (2004). Carotenoids/vitamin C and smoking-related bladder cancer. Int J Cancer, 110, 417-423. https://doi.org/10.1002/ijc.20104
  8. De Stefani E, Aune D, Boffetta P, et al (2009). Salted meat consumption and the risk of cancer: a multisite case-control study in Uruguay. Asian Pac J Cancer Prev, 10, 853-857.
  9. De Stefani E, Deneo-Pellegrini H, Ronco AL, et al (2011). Dietary cholesterol and risk of cancer: a multisite casecontrol study in Uruguay. Med Hypotheses Res, 7, 17-25.
  10. De Stefani E, Boffetta P, Ronco AL, et al (2012). Processed meat consumption and risk of cancer: a multisite case-control study in Uruguay. Br J Cancer, 107, 1584-1588. https://doi.org/10.1038/bjc.2012.433
  11. Fang D, Tan F, Wang C, et al (2012). Egg intake and bladder cancer risk: A meta-analysis. Exper Therap Medicine, 4, 906-912.
  12. Garcia-Closas R, Garcia-Closas M, Kogevinas M, et al (2007). Food, nutrition and heterocyclic amine intake and the risk of bladder cancer. Eur J Cancer, 43, 1731-40. https://doi.org/10.1016/j.ejca.2007.05.007
  13. Hu J, La Vecchia C, DesMeules M, et al (2008). Meat and fish consumption and cancer in Canada. Nutr Cancer, 60, 313-24. https://doi.org/10.1080/01635580701759724
  14. Hu J, La Vecchia C, de Groh M, et al (2012). Dietary cholesterol intake and cancer. Ann Oncol, 23, 491-500. https://doi.org/10.1093/annonc/mdr155
  15. Jakszyn P, Gonzalez CA, Lujan-Barroso L, et al (2011). Red meat, dietary nitrosamines, and heme iron and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomarkers Prev, 20, 555-9. https://doi.org/10.1158/1055-9965.EPI-10-0971
  16. La Vecchia C, Negri E (1996). Nutrition and bladder cancer. Cancer Causes Control, 7, 95-100. https://doi.org/10.1007/BF00115641
  17. Larsson SC, Johansson JE, Andersson SO, Wolk A (2009). Meat consumption and bladder cancer risk in a prospective cohort. Cancer Causes Control, 20, 35-40. https://doi.org/10.1007/s10552-008-9214-x
  18. Michaud DS, Holick CN, Giovannucci E, Stampfer MJ (2006). Meat intake and bladder cancer risk in 2 prospective cohort studies. Am J Clin Nutr, 84, 1177-83.
  19. Moore MA, Baumann F, Foliaki S, et al (2009). Cancer epidemiology in the Pacific Islands-past, present, and future. Asian Pac J Cancer Prev, 10, 93-8.
  20. Rohani-Rasaf M, Abdollahi M, Jazayeri S et al (2013). Correlation of cancer incidence with diet, smoking and socio-economic position across 22 districts of Tehran in 2008. Asian Pac J Cancer Prev, 14, 1669-76. https://doi.org/10.7314/APJCP.2013.14.3.1669
  21. Ronco AL, De Stefani E, Boffetta P, et al (2006). Food patterns and risk of breast cancer: a factor analysis study in Uruguay. Int J Cancer, 119, 1672-8. https://doi.org/10.1002/ijc.22021
  22. Rothman KJ, Greenland S, Lash TL (2008). Modern Epidemiology. Third Edition. Lippincott Williams & Wilkins, Philadelphia, pp 381-417.
  23. StataCorp (2013). Stata Statistical Software: Release 13. College Station, Texas: StataCorp LT.
  24. Tavani A, La Vecchia C, Gallus S, et al (2000). Red meat intake and cancer risk: a study in Italy. Int J Cancer, 86, 425-8. https://doi.org/10.1002/(SICI)1097-0215(20000501)86:3<425::AID-IJC19>3.0.CO;2-S
  25. Wakai K, Hirose K, Takezaki T, et al (2004). Foods and beverages in relation to urothelial cancer: a case-control study in Japan. Int J Urol, 11, 11-9. https://doi.org/10.1111/j.1442-2042.2004.00740.x
  26. Wilkens LR, Kadir MM, Kolonel LN, et al (1996). Risk factors for lower urinary tract cancer: the role of total fluid consumption, nitrites and nitrosamines and selected foods. Cancer Epidemiol Biomarkers Prev, 5, 161-6.
  27. Willett WC (1998). Nutritional Epidemiology. Second Edition. Monographs in Epidemiology and Biostatistics Volume 30. Oxford University Press, New York, pp 273-301.
  28. World Cancer Research Fund/American Institute Cancer Research (2007). Food, Nutrition, Physical Activity, and the Prevention of Cancer, a Global Perspective. Washington DC.

Cited by

  1. Red and processed meat consumption and risk of bladder cancer: a dose–response meta-analysis of epidemiological studies pp.1435-1293, 2016, https://doi.org/10.1007/s00394-016-1356-0
  2. Dietary patterns and risk of recurrence and progression in non-muscle-invasive bladder cancer vol.142, pp.9, 2017, https://doi.org/10.1002/ijc.31214