- Volume 15 Issue 14
DOI QR Code
Factors Influencing Ventilator-Associated Pneumonia in Cancer Patients
- Park, Sun-A (Office of Infection Control, National Cancer Center in Korea) ;
- Cho, Sung Sook (Office of Infection Control, National Cancer Center in Korea) ;
- Kwak, Gyu Jin (Intensive Care Unit, National Cancer Center in Korea)
- Published : 2014.07.30
Background: With increasing survival periods and diversification of treatment methods, treatment of critically ill cancer patients has become an important factor influencing patient prognosis. Patients with cancer are at high risk of infections and subsequent complications. This study investigated the incidence and factors contributing to the development of ventilator-associated pneumonia (VAP). Materials and Methods: This retrospective study investigated the incidence of VAP and factors leading to infection in patients admitted to the intensive care unit (ICU) of a cancer center from January 1, 2012 to December 31, 2013. Results: The incidence of VAP was 2.13 cases per 1,000 days of intubation, and 13 of 288 patients (4.5%) developed VAP. Lung cancer was the most common cancer associated with VAP (N=7, 53.9%), and longer hospital stays and intubation were associated with increased VAP incidence. In the group using a "ventilator bundle," the incidence was 1.14 cases per 1,000 days compared to 2.89 cases per 1,000 days without its use; however, this difference was not statistically significant (p=0.158). Age (
- Alok G, Avinash A, Sanjay M, et al (2011). Incidence, risk stratification, antibiogram of pathogens isolated and clinical outcome of ventilator associated pneumonia. Indian J Crit Care Med, 15, 96-101. https://doi.org/10.4103/0972-5229.83015
- Ban KO (2007). The Development and Effectiveness of a Program to Prevent Ventilator Associated Pneumoni In the ICU . Seoul:Yonsei Univ.
- Bird D, Zambuto A, O'Donnell C, et al (2010). Adherence to ventilator-associated pneumonia bundle and incidence of ventilator-associated pneumonia in the surgical intensive care unit. Arch Surg, 145, 465-70. https://doi.org/10.1001/archsurg.2010.69
- Chastre, J, Fagon, J Y (2002). Ventilator-associated pneumonia. Am J Respiratory Critical Care Med, 165, 867-903. https://doi.org/10.1164/ajrccm.165.7.2105078
- Chen, YY, Chen, LY, Lin SY, et al (2012). Surveillance on secular trends of incidence and mortality for device-associated infection in the intensive care unit setting at a tertiary medical center in Taiwan, 2000-2008: A retrospective observational study. BioMed Central Infectious Diseases, 209, 1471-2334.
- Cho KH, Park SH, Lee KS, et al (2013). A single measure of cancer burden in Korea from 1999 to 2010. Asian Pac J Cancer Prev, 14, 5249-55. https://doi.org/10.7314/APJCP.2013.14.9.5249
- Cook D J (2000). Ventilator-associated pneumonia: perspectives on the burden of illness. Intensive Care Med, 26, 31-7. https://doi.org/10.1007/s001340050008
- Danai PA, Moss M, Mannino DM, et al (2006). The Epidemiology of sepsis in patients with malignancy. Chest, 129, 1432-40. https://doi.org/10.1378/chest.129.6.1432
- Bufalo CD, Morelli A, Bassein L, et al (1995). Severity score in respiratory intensive care; APACHE II predicted mortality better than SAPSII. Respir Care, 40, 1042-7.
- Fagon JY (2002). Prevention of ventilator-associated pneumonia. Intensive Care Med, 28, 822-3. https://doi.org/10.1007/s00134-002-1341-3
- Harris JR, Miller TH (2000). Preventing nosocomial pneumonia: evidence-based practice. Crit Care Nurse, 20, 51-66.
- Hasan MA, Aiman E, Asgar HR, et al (2012). The result of 6-year epidemiologic surveillance for ventilator-associated pneumonia at a tertiary care intensive care unit in Saudi Arabia. Am J Infection Control, 40, 794-9. https://doi.org/10.1016/j.ajic.2011.10.004
- Jeon MH, Park WB, Kim SR, et al (2012). Korean Nosocomial Infections Surveillance System, Intensive Care Unit Module Report Data Summary from July 2010 through June 2011 (2012). Korean J Nosocomial Infection Control, 16, 1-12.
- Jung KW, Shin HR, Kong HJ, et al (2010). Long-term trends in cancer mortality in Korea (1983-2007):a joinpoint regression analysis. Asian Pac J Cancer Prev, 11, 1451-7.
- Kang NM, Xiao N, Sun XJ et al (2013). Analysis of ICU treatment on resection of giant tumors in the mediastinum of the thoracic cavity. Asian Pac J Cancer Prev, 14, 3843-6. https://doi.org/10.7314/APJCP.2013.14.6.3843
- Kim Y.J, Kim MJ, Cho YJ, et al (2014). Who should be admitted to the intensive care unit? The outcome of intensive care unit admission in stage IIIB--IV lung cancer patients. Med Oncol, 31, 847. https://doi.org/10.1007/s12032-014-0847-1
- Kollef MH, Prentice D, Shapiro SD, et al (1997). Mechanical ventilation with or without daily changes of in-line suction catheters. Am J Respir Crit Care Med, 156, 466-72. https://doi.org/10.1164/ajrccm.156.2.9612083
- Kwak YG, Cho YK, Kim JY, et al (2010). Korean Nosocomial Infections Surveillance System, Intensive Care Unit Module Report Data Summary from July 2008 through June 2009 and analysis of 3-Year Results. Korean J Nosocomial Infection Control, 15, 14-25.
- Kwak YG, Cho YK, Kim JY, et al (2011). Korean Nosocomial Infections Surveillance System, Intensive Care Unit Module Report Data Summary from July 2009 through June 2010. Korean J Nosocomial Infection Control, 16, 1-12.
- Lee JH (2008). Incidence Rate and Risk Factor for Ventilator Associated Pneumonia in Intensive Care Unit. Seoul:Kerea Univ.
- Martin GS, Mannino DM, Eaton S, et al (2003). The Epidemiology of Sepsis in the United States from 1979 through 2000, N Engl J Med, 348, 1546-54. https://doi.org/10.1056/NEJMoa022139
- Maxima L, Ramon P, Manuel C, et al (2006). Nosocomial infection surveillance in a surgical intensive care unit in Spain, 1996-2000 : A time-trend analysis. Infection Control Hospital Epidemiology, 27, 54-9. https://doi.org/10.1086/499167
- Resar R, Pronovost P, Haraden C, et al (2005). Using a bundle approach to improve ventilator care processes and reduce ventilator-associated pneumonia. Jt Comm J Qual Patient Saf, 31, 243-8.
- Safdar A, Armstrong D (2001). Infectious morbidity in critically ill patients with cancer. Crit Care Clin, 17, 531-70. https://doi.org/10.1016/S0749-0704(05)70198-6
- Seo HK, Choi EH, Kim JH (2011). The effect of Oral Hygiene for Ventilator Associated Pneumonia(VAP) Incidence. J Korean Critical Care Nursing, 4, 39-46.
- Shin TR, Cheon SH, Chang JH (1998). Comparative analysis of risk factors and severity of illness scores for predicting mortality in sepsis patients treated in medical intensive care unit. Korean J Med, 55, 11-20.
- Shin HR, Masuyer E, Ferlay J, et al (2010). Cancer in Asia - incidence rates based on data in Cancer Incidence in Five Continents IX (1998-2002). Asian Pac J Cancer Prev, 11, 11-6.
- Tablan OC, Anderson LJ, Besser R, et al (2004). Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep, 53, 1-36.
- Wang Z, Cai XJ, Shi L et al (2014). Risk factors of postoperative nosocomial pneumonia in stage I-IIIa lung cancer patients. Asian Pac J Cancer Prev, 15, 3071-4. https://doi.org/10.7314/APJCP.2014.15.7.3071
- Wigmore TJ, Farquhar-Smith P, Lawson A (2013). Intensive care for the cancer patient - Unique clinical and ethical challenges and outcomeprediction in the critically ill cancer patient. Best Practice Research Clinical Anaesthesiology, 23, 527-43.
- Mannose-modified chitosan microspheres enhance OprF-OprI-mediated protection of mice against Pseudomonas aeruginosa infection via induction of mucosal immunity vol.99, pp.2, 2015, https://doi.org/10.1007/s00253-014-6147-z
- Decreasing incidence and mortality among hospitalized patients suffering a ventilator-associated pneumonia vol.96, pp.30, 2017, https://doi.org/10.1097/MD.0000000000007625