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Combined Effects of Six Cytokine Gene Polymorphisms and SNP-SNP Interactions on Hepatocellular Carcinoma Risk in Southern Guangxi, China

  • Bei, Chun-Hua (Department of Epidemiology, School of Public Health, Guangxi Medical University) ;
  • Bai, Hua (School of Public Health, Kunming Medical University) ;
  • Yu, Hong-Ping (School of Public Health, Guilin Medical University) ;
  • Yang, Yan (Department of Endocrinology, JiangBin Hospital of Guangxi) ;
  • Liang, Qing-Qing (School of Public Health, Guilin Medical University) ;
  • Deng, Ying-Ying (Guilin Disease Pevention and Control Center) ;
  • Tan, Sheng-Kui (School of Public Health, Guilin Medical University) ;
  • Qiu, Xiao-Qiang (Department of Epidemiology, School of Public Health, Guangxi Medical University)
  • Published : 2014.08.30

Abstract

Cytokine gene single nucleotide polymorphisms (SNPs) are involved in the genesis and progression of hepatocellular carcinoma (HCC). We hypothesized that combined effects of cytokine gene SNPs and SNP-SNP interactions are associated with HCC risk. Six SNPs in cytokine genes (IL-2, IFN-${\gamma}$, IL-$1{\beta}$, IL-6, and IL-10) were genotyped in a study of 720 Chinese HCC cases and 784 cancer-free controls. Although none of these SNPs individually had a significant effect on the risk of HCC, we found that the combined effects of these six SNPs may contribute to HCC risk (OR=1.821, 95% CI=1.078-3.075). This risk was pronounced among smokers, drinkers, and hepatitis B virus carriers. A SNP-SNP interaction between IL-2-330 and IFN-${\gamma}$-1615 was associated with an increased HCC risk (OR=1.078, 95% CI=1.022-1.136). In conclusion, combined effects of SNPs and SNP-SNP interactions in cytokine genes may contribute to HCC risk.

Keywords

Cytokine genes;polymorphisms;interaction;risk;hepatocellular carcinoma;China

Acknowledgement

Supported by : National Natural Science Foundation of China

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