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Association between ABCB1 Immunohistochemical Expression and Overall Survival in Gastric Cancer Patients

  • de Oliveira, Juliana (Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, UNIFESP) ;
  • Felipe, Aledson Vitor (Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, UNIFESP) ;
  • Neto, Ricardo Artigiani (Department of Pathology, Federal University of Sao Paulo, UNIFESP) ;
  • Oshima, Celina Tizuko (Department of Pathology, Federal University of Sao Paulo, UNIFESP) ;
  • de Souza Silva, Marcelo (Department of Pathology, Federal University of Sao Paulo, UNIFESP) ;
  • Forones, Nora Manoukian (Department of Medicine, Gastroenterology Division, Federal University of Sao Paulo, UNIFESP)
  • Published : 2014.08.30

Abstract

Gastric cancer (GC) is one of the most common malignancies worldwide. The ABCB1 protein, a member of the ATP-binding cassette (ABC) transporter family, encoded by the ABCB1 gene, considerably influences the distribution of drugs across cell membranes as well as multidrug resistance (MDR) of antineoplastic drugs. In contrast to the extensive knowledge on the pharmacological action of ABCB1 protein, the correlation between the clinical-pathological data and ABCB1 protein expression in patients with GC remains unclear. The aim was to investigate association between ABCB1 expression and overall survival in GC patients. Human tumor fragments from 57 GC patients were examined by immunohistochemistry assay. We observed lower survival rate of patients with GC who were positive for ABCB1 expression (p=0.030). Based on these observations, we conclude that GC patients with positive ABCB1 protein immunohistochemical expression in their tumors suffer shorter overall survival.

Keywords

ABCB1;immunohistochemistry;gastric cancer;survival

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