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Lack of Relation of Survivin Gene Expression with Survival and Surgical Prognostic Factors in Endometrial Carcinoma Patients

  • Aksoy, Rifat Taner (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Thran, Ahmet Taner (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Boran, Nurettin (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Tokmak, Aytekin (Zekai Tahir Burak Women Health Education and Research Hospital) ;
  • Isikdogan, Betul Zuhal (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Dogan, Mehmet (Department of Pathology, Oncology Education and Research Hospital) ;
  • Thlunay, Hakki Gokhan (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital)
  • Published : 2014.08.30

Abstract

Background: The relation ofsurvivin gene expression to survival and surgical prognostic factors in the patients with endometrial carcinoma is unclear. Materials and Methods: In this study, 62 cases who were operated due to endometrial carcinoma were investigated between 2003 and 2011 in the the gynecological oncology clinic of Female Disease Training and Investigation Hospital of Etlik Zubeyde, Hanim, Turkey. Clinical and surgical prognostic factors were investigated by screening the records of these cases. With the standard streptavidin-biotin immune peroxidase method, cytoplasmic and nuclear expression of survivin was investigated in sections with specific antibodies (1:100, diagnostic Bio Systems, USA) primer. The aim was to elucidate any relation between survivin expression and defined prognostic factors and survival. Results: There was no statistically significant relationship between cytoplasmic and nuclear indexes identified for survivin and age, body mass index, the levels of preoperative hemoglobin, platelet and Ca 125, stage, grade, lymph node meastasis, the number of meta statical lymph nodes (total, paraaortic and pelvic), myometrial invasion, serosal invasion, adnexal involvement, the presence of acid in the first diagnosis, the involvement of omentum, the adjuvant treatment application of the cases, the presence of recurrence and rate of mortality (p>0.05). Statistical significance was noted for the presence of advanced stage lymph node metastasis (pelvic, paraaortic, pelvic and paraaortic), serosal involvement, positive cytology, lymph vascular space invasion, intra abdominal metastasis, and omentum involvement. When investigated the relation between cytoplasmic and nuclear survivin indexes and total survival, the result was not statistically significant (p>0.05). Conclusions: In our study, there was no statistically significant relationship between the rates of cytoplasmic and nuclear survivin expression with identified prognostic factors and total or non-disease survival.

Keywords

Survivin;endometrial carcinoma;survival;Turkey

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