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Recently Emerging Signaling Landscape of Ataxia-Telangiectasia Mutated (ATM) Kinase

  • Farooqi, Ammad Ahmad (Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College) ;
  • Attar, Rukset (Department of Obstetrics and Gynecology, Yeditepe University Faculty of Medicine) ;
  • Arslan, Belkis Atasever (Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University) ;
  • Romero, Mirna Azalea (Laboratorio de Farmacologia, Unidad Academica de Medicina, Universidad Autonoma de Guerrero) ;
  • ul Haq, Muhammad Fahim (Department of Biochemistry, RLMC) ;
  • Qadir, Muhammad Imran (Institute of Molecular Biology and Biotechnology, BZU)
  • Published : 2014.08.30

Abstract

Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.

Keywords

Ataxia-telangiectasia mutated kinase;signalling landscape;cancer therapy

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