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SCYL1BP1 has Tumor-suppressive Functions in Human Lung Squamous Carcinoma Cells by Regulating Degradation of MDM2

  • Yang, Zhi-Ping (Department of Oncology and Pathology, The First Hospital of Jiaxing) ;
  • Xie, Yong-Hong (Department of Pathology, Jiaxing University College of Medicine) ;
  • Ling, Dan-Yan (Shanghai Emay Biotechnologies Co., Ltd.) ;
  • Li, Jin-Rui (Department of Oncology and Pathology, The First Hospital of Jiaxing) ;
  • Jiang, Jin (Department of Oncology and Pathology, The First Hospital of Jiaxing) ;
  • Fan, Yao-Hua (Department of Oncology and Pathology, The First Hospital of Jiaxing) ;
  • Zheng, Jia-Lian (Department of Oncology and Pathology, The First Hospital of Jiaxing) ;
  • Wu, Wan-Xin (Department of Oncology and Pathology, The First Hospital of Jiaxing)
  • Published : 2014.09.15

Abstract

SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior remain poorly understood. In this study, we present evidence that SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung squamous carcinoma cell lines. Functional assays found that reintroduction of SCYL1BP1 into lung squamous carcinoma cell lines significantly inhibited cell proliferation, migration, invasion and tumor formation in nude mice, suggesting strong tumor suppressive function of SCYL1BP1 in lung squamous carcinoma. Taken together, our data suggest that the interaction of SCYL1BP1/MDM2 could accelerate MDM2 degradation, and may function as an important tumor suppressor in lung squamous carcinomas.

Keywords

SCYL1BP1;MDM2;lung squamous carcinoma cells;suppressor action

Acknowledgement

Supported by : Zhejiang province

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