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Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis

  • Lin, Zhuo (Department of Infection and Liver Diseases, Institution of Hepatology, the First Affiliated Hospital of Wenzhou Medical University) ;
  • Chen, Li (Institute of Genomic Medicine, Wenzhou Medical University) ;
  • Song, Mei (Department of Infection and Liver Diseases, Institution of Hepatology, the First Affiliated Hospital of Wenzhou Medical University) ;
  • Shi, Ke-Qing (Department of Infection and Liver Diseases, Institution of Hepatology, the First Affiliated Hospital of Wenzhou Medical University) ;
  • Tang, Kai-Fu (Institute of Genomic Medicine, Wenzhou Medical University)
  • Published : 2014.09.15

Abstract

MicroRNAs (miRNAs) act as tumor suppressors or promoters in neoplasia by regulating relative geneexpression. The association between a single nucleotide polymorphism (SNP) rs4938723 in miR-34b/c and susceptibility to cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed, Web of Science and Embase to identify all relevant studies in this meta-analysis with 6,036 cases and 6,204 controls. We found that the miR-34b/c rs4938723 polymorphism was significantly associated with increased risk of cancers in the heterozygous model (TC versus TT, OR=1.09, 95% CI=1.01-1.18, P=0.02). Subgroup analysis also revealed increased risk for Asian ethnicity in the heterozygous model (TC versus TT, OR=1.12, 95% CI=1.02-1.22, P=0.02), but decreased risk of colorectal cancer in homozygote model (CC versus TT, OR=0.66, 95% CI=0.47-0.92, P=0.02) and in the recessive model (CC versus TC+TT, OR=0.67, 95% CI=0.48-0.93, P=0.02) by cancer type. The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer. Well-designed studies with larger sample size are required to further validate the results.

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