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Score Based Risk Assessment of Lung Cancer and its Evaluation for Bangladeshi People

  • Mukti, Roushney Fatima (Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University) ;
  • Samadder, Pratul Dipta (Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University) ;
  • Emran, Abdullah Al (Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University) ;
  • Ahmed, Farzana (Department of Mathematics and Natural Sciences, BRAC University) ;
  • Imran, Iqbal Bin (Faculty of Science and Forestry, University of Eastern Finland) ;
  • Malaker, Anyanna (Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University) ;
  • Yeasmin, Sabina (Department of Genetic Engineering and Biotechnology, University of Dhaka)
  • Published : 2014.09.15

Abstract

Background: The problem of cancer, especially lung cancer, is very acute in Bangladesh. The present study was conducted to evaluate the risk of lung cancer among Bangladeshi people based on hereditary, socio-economic and demographic factors. Materials and Methods: This study was carried out in 208 people (patients-104, controls-104) from January 2012 to September 2013 using a structured questionnaire containing details of lung cancer risk factors including smoking, secondhand smoke, tobacco leaf intake, age, gender, family history, chronic lung diseases, radiotherapy in the chest area, diet, obesity, physical activity, alcohol consumption, occupation, education, and income. Descriptive statistics and testing of hypotheses were used for the analysis using SPSS software (version 20). Results: According to this study, lung cancer was more prevalent in males than females. Smoking was the highest risk factor (OR=9.707; RR=3.924; sensitivity=0.8872 and P<0.0001) followed by previous lung disease (asthma, tuberculosis etc.) (OR=7.095; RR=1.508; sensitivity=0.316 and P<0.0001)) for male patients. Highly cooked food (OR=2.485; RR=1.126; sensitivity=0.418 and P=0.004)) and also genetic inheritance (OR=1.93; RR=1.335; sensitivity=0.163 and P=0.138) demonstrated significant correlation with lung cancer as risk factors after these two and alcohol consumption was not prevalent. On the other hand, for female patients, tobacco leaf intake represented the highest risk (OR=2.00; RR=1.429; sensitivity= 0.667 and P=0.5603) while genetic inheritance and highly cooked food also correlate with lung cancer but not so significantly. Socioeconomic status and education level also play important roles in causing lung cancer. Some 78.5% male and 83.3% of female cancer patients were rural residents, while 58.2% lived at the margin or below the poverty line. Most male (39.8%) and female (50.0%) patients had completed only primary level education, and 27.6% male and 33.3% female patients were illiterate. Smoking was found to be more prevalent among the less educated persons. Conclusions: The results obtained in this study indicate the importance of creating awareness about lung cancer risk factors among Bangladeshi people and making appropriate access to health services for the illiterate, poor, rural people.

Keywords

Lung cancer;risk assessment;smoking;genetic factor;socio-demographics;awareness;Bangladesh

References

  1. Mohammad Abul Bashar Sarker, Md. Harun-Or-Rashid,Tomoya Hirosawa et al (2012). Trends and distributions of common types of cancer in Bangladesh: results from the cancer registry data of 2008-10, Ann Cancer Res Therapy, 20, 32-38. https://doi.org/10.4993/acrt.20.32
  2. Luqman M, Javed MM, Daud S, et al (2014). Risk factors for lung cancer in the Pakistani population. Asian Pac J Cancer Prev, 15, 3035-9. https://doi.org/10.7314/APJCP.2014.15.7.3035
  3. Moore MA, Ariyaratne Y, Badar F, et al (2010). Cancer epidemiology in South Asia - past, present and future. Asian Pac J Cancer Prev, 11, 49-66.
  4. Parkin DM, Darby SC (2011). Cancers in 2010 attributable to ionising radiation exposure in the UK. Br J Cancer, 105, 57-65. https://doi.org/10.1038/bjc.2011.485
  5. Rosenberger A, Bickeboller H, McCormack V, et al (2012). Asthma and lung cancer risk: a systematic investigation by the international lung cancer consortium. Carcinogenesis, 33, 587-97. https://doi.org/10.1093/carcin/bgr307
  6. Rushton L, Hutchings SJ, Fortunato L, et al (2012). Occupational cancer burden in great britain. Br J Cancer, 107, 3-7. https://doi.org/10.1038/bjc.2012.112
  7. Siegel R, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer J Clin, 63, 11-30. https://doi.org/10.3322/caac.21166
  8. Talukder MH, Jabeen S, Islam MJ, Hussain SMA (2008). Distribution of cancer patients at national institute of cancer research and hospital in 2006. Bangladesh Med J, 37, 2-5.
  9. Thun M, Peto R, Boreham J, Lopez AD(2012). Stages of the cigarette epidemic on entering its second century. Tob Control, 21, 96-101. https://doi.org/10.1136/tobaccocontrol-2011-050294
  10. Wingo PA, Ries LAG, GiovinoGA, et al (1999). Annual report to the nation on the status of the cancer, 1973-1996, with special section on lung cancer and tobacco smoking. J Natl Cancer Inst, 91, 675-90. https://doi.org/10.1093/jnci/91.8.675
  11. World Cancer Research Fund/American institute for cancer research (WCRF/AICR). food, nutrition, physical activity, and the prevention of cancer: a global perspective. washington DC: AICR, 2007.
  12. Yano T, Haro A, Shikada Y et al (2011).Non-small cell lung cancer in never smokers as a representative 'non-smokingassociated lung cancer': epidemiology and clinical features. Int J Clin Oncol, 16, 287-93. https://doi.org/10.1007/s10147-010-0160-8
  13. Bagnardi V, Rota M, Botteri E, et al (2011). Alcohol consumption and lung cancer risk in never smokers: a meta-analysis. Ann Oncol, 22, 2631-39. https://doi.org/10.1093/annonc/mdr027
  14. Brenner DR, McLaughlin JR, Hung RJ (2011). Previous lung diseases and lung cancer risk: a systematic review and metaanalysis. PLoS ONE, 6, 174-79.
  15. Chao C, Li Q, Zhang F, White E (2011). Alcohol consumption and risk of lung cancer in the VITamins And Lifestyle Study. Nutr Cancer, 63, 880-8. https://doi.org/10.1080/01635581.2011.582222
  16. Chawla R, Sathian B, Mehra A, et al (2010). Awareness and assessment of risk factors for lung cancer in residents of Pokhara valley. Asian Pac J Cancer Prev, 11, 1789-93.
  17. Cogliano VJ, Baan R, Straif K, et al (2011). Preventable exposures associated with human cancers. J Natl Cancer I, 103, 1827-39. https://doi.org/10.1093/jnci/djr483
  18. Aarts MJ, Kamphuis CB, Louwman MJ et al(2013) Educational inequalities in cancer survival: a role for comorbidities and health behaviours? J Epidemiol Community Health, 67, 365-73 https://doi.org/10.1136/jech-2012-201404
  19. Ahmed K, Emran AA, Jesmin T, et al (2013). Early detection of lung cancer risk using data mining. Asian Pac J Cancer Prev, 14, 595-8. https://doi.org/10.7314/APJCP.2013.14.1.595
  20. Cote ML, Liu M, Bonassi S, Neri M, et al (2012). Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium. Eur J Cancer, 48, 1957-68. https://doi.org/10.1016/j.ejca.2012.01.038
  21. De Onis M, Habicht JP (1996) Anthropometric reference data for international use: recommendations from a world health organization expert committee. Am J Clin Nutrition, 64, 650-8
  22. Ferlay J, Shin HR, Bray F, et al (2010). Cancer incidence and mortality worldwide. GLOBOCAN 2008: IARC cancer Base No.10 [Internet]. Lyon, France: International agency for research on cancer.
  23. Fokhru IM, Nazmul H, Anjuman B, et al ( 2012).Distribution of cancer patients and patterns of cancer treatment at dhaka medical college hospital, Bangladesh. Int Res J Pharmacy, 3, 1-5
  24. Friedenreich CM, Neilson HK, Lynch BM (2010). State of the epidemiological evidence on physical activity and cancer prevention. Eur J Cancer, 46, 2593-604. https://doi.org/10.1016/j.ejca.2010.07.028
  25. Fucic A, Gamulin M, Ferencic Z, et al (2010). Lung cancer and environmental chemical exposure: a review of our current state of knowledge with reference to the role of hormones and hormone receptors as an increased risk factor for developing lung cancer in man. Toxicol Pathol, 38, 849-55. https://doi.org/10.1177/0192623310378136
  26. Hashibe M, Siwakoti B, Wei M, et al (2011). Socioeconomic status and lung cancer risk in Nepal. Asian Pac J Cancer Prev, 12, 1083-8.
  27. Kamsa-Ard S, Promthet S, Lewington S, et al (2013). Association between smoking and mortality: Khon Kaen cohort study, Thailand. Asian Pac J Cancer Prev, 14, 2643-7. https://doi.org/10.7314/APJCP.2013.14.4.2643
  28. Kreuzer M, Heinrich J, Kreienbrock L, et al (2002). Risk factors for lung cancer among nonsmoking women. Int J Cancer, 100, 706-13 https://doi.org/10.1002/ijc.10549

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