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Cyclooxygenase-2 Promoter 765C Increase of Digestive Tract Cancer Risk in the Chinese Population: a Meta-analysis

  • Xu, Yan-Song (Department of Emergency, First Affiliated Hospital, Guangxi Medical University) ;
  • Zhao, Bo (Department of General Surgery, First Affiliated Hospital, Guangxi Medical University) ;
  • Long, Chen-Yan (Department of General Surgery, Center Hospital) ;
  • Li, Hui (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University) ;
  • Lu, Xing (Department of Emergency, First Affiliated Hospital, Guangxi Medical University) ;
  • Liu, Gang (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University) ;
  • Tang, Xiao-Zhun (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University) ;
  • Tang, Wei-Zhong (Department of Colorectal and Anal, First Affiliated Hospital, Guangxi Medical University)
  • Published : 2014.06.15

Abstract

Background: To evaluate relationship between the cyclooxygenase-2 promoter 765G/C polymorphism and digestive cancer risk in China. Materials and Methods: A literature search through February 2014 was performed using PubMed, Chinese Biomedical Literature Database (CBM) and China National Knowledge Infrastructure (CNKI) databases, and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs. Results: In total, 9 articles with 3,263 cases and 4,858 controls were included in this meta-analysis. The pooled OR (95%CIs) in the co-dominant model (GC vs GG) was 1.56 [1.19, 2.06], and in the dominant model ((CC+GC) vs GG), the pooled OR was 1.59 [1.21, 2.09] in overall cancers. In the subgroup analysis, stratified by cancer type, significant associations were found that the-765C allele had increased pancreatic cancer and gastric risk. No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found. Conclusions: These findings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreatic cancer risk.

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