- Volume 15 Issue 11
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Chemoradiation Related Acute Morbidity in Carcinoma Cervix and Correlation with Hematologic Toxicity: A South Indian Prospective Study
- Kumaran, Aswathy (Department of Obstetrics Gynecology, Kasturba Medical College) ;
- Guruvare, Shyamala (Department of Obstetrics Gynecology, Kasturba Medical College) ;
- Sharan, Krishna (Department of Radiation Oncology, Kasturba Medical College) ;
- Rai, Lavanya (Department of Obstetrics Gynecology, Kasturba Medical College) ;
- Hebbar, Shripad (Department of Obstetrics Gynecology, Kasturba Medical College)
- Published : 2014.06.15
Purpose: To assess chemoradiation related acute morbidity in women with carcinoma cervix and to find and correlation between hematologic toxicity and organ system specific damage. Materials and Methods: A prospective study was carried out between August 2012 and July 2013 enrolling 79 women with cancer cervix receiving chemo-radiotherapy. Weekly assessment of acute morbidity was done using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4 and the toxicities were graded. Results: Anemia [77 (97.5%)], vomiting [75 (94.8%)] and diarrhea [72 (91.1%)], leukopenia [11 (13.9%)], cystitis [28 (35.4%], dermatitis [19 (24.1%)] and fatigue [29 (36.71%)] were the acute toxicities noted. The toxicities were most severe in
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