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Prevalence, Risk Factors and Disease Knowledge of Breast Cancer in Pakistan

  • Asif, Hafiz Muhammad (Department of Eastern Medicine & Surgery, Faculty of Medical & Health Sciences, The University of Poonch) ;
  • Sultana, Sabira (Faculty of Pharmacy & Alternative Medicine, The Islamic University of Bahawalpur) ;
  • Akhtar, Naveed (Faculty of Pharmacy & Alternative Medicine, The Islamic University of Bahawalpur) ;
  • Rehman, Jalil Ur. (Faculty of Pharmacy & Alternative Medicine, The Islamic University of Bahawalpur) ;
  • Rehman, Riaz Ur. (Department of Eastern Medicine & Surgery, Directorate of Medical Sciences, GCU)
  • Published : 2014.06.15

Abstract

Breast cancer is the most common cancer in females all over the world with approximately one million new cases each year as well as one of second leading causes of death among females. In Pakistan, the most frequently diagnosed cancer among females is also breast cancer, accounting for nearly one in nine female patients. Its incidence in Pakistan is 2.5 times higher than that in neighboring countries like Iran and India. The risk factors associated with breast cancer are age, family history, early menarche, intake of combined estrogen and progestin menopausal hormones, alcohol consumption, physical inactivity, low socioeconomic status and lack of awareness regarding the disease. This mini-review article aims to provide awareness about breast cancer as well as an updated knowledge about the prevalence, risk factors and disease knowledge of breast cancer in Pakistan.

References

  1. Adrian Lee, Carlos Arteaga (2009). "32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium". Sunday Morning Year-End Review.
  2. American Society of Clinical Oncology (2012). "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation (American Society of Clinical Oncology), retrieved 14 August 2012.
  3. Aziz I, Muhammad UR, Faisal S, Abdul RS (2013). Frequency of pro allele on codon 72 of TP53 in female breast cancer patients of Pakistan. Pak J Zool, 45, 1437-46.
  4. Badar F, Faruqui ZS, Uddin N, et al (2011). Management of breast lesions by breast physicians in a heavily populated south asian developing country. Asian Pac J Cancer Prev, 12, 827-32.
  5. Bhurgri Y (2004). Karachi Cancer Registry Data implications for the National Cancer Control Program of Pakistan. Asian Pac J Cancer Prev, 5, 77-82.
  6. Bhurgri Y, Bhurgri A, Pervez S, et al (2005). Cancer profile of Hyderabad, Pakistan 1998-2002. Asian Pac J Cancer Prev, 6, 474-80.
  7. Bhurgri Y, Kayani N, Faridi N, et al (2007). Patho-epidemiology of breast cancer in Karachi, 1995-1997. Asian Pac J Cancer Prev, 8, 215-20.
  8. Bhurgri, Y, Bhurgri, A, Hasan, SH, et al (2000), Cancer incidence in Karachi, Pakistan: First results from Karachi cancer registry. Int J Cancer, 85, 325-29. https://doi.org/10.1002/(SICI)1097-0215(20000201)85:3<325::AID-IJC5>3.0.CO;2-J
  9. Butt Z, Shahbaz U, Naseem T, et al (2009). Reproductive risk factors for female breast cancer: a case-control study. Annals, 15, 206-10.
  10. Boffetta P, Hashibe M, La Vecchia C, Zatonski W, Rehm J (2006). The burden of cancer attributable to alcohol drinking. Int J Cancer, 119, 884-7. https://doi.org/10.1002/ijc.21903
  11. Brody JG, Rudel RA, Michels KB, et al (2007). Environmental pollutants, diet, physical activity, body size, and breast cancer: where do we stand in research to identify opportunities for prevention? Cancer, 109, 2627-34. https://doi.org/10.1002/cncr.22656
  12. Butt Z, Haider SF, Arif S, et al (2012). Breast cancer risk factors: A comparison between pre-menopausal and post-menopausal women, J Pak Med Assoc, 62, 120-4.
  13. Choi NW, Howe GR, Miller AB, et al (1978). An epidemiologic study of the breast cancer. Am J Epidemiol, 107, 510-21.
  14. Faheem M, Muhammad K, Imran AJ, et al (2007). Risk factors for breast cancer in patients treated at NORI Hospital, Islamabad. J Pak Med Assoc, 57, 242-5.
  15. Farooq A, Naveed AK, Azeem Z, Ahmad T (2011). Breast and ovarian cancer risk due to prevalence of BRCA1 and BRCA2 variants in Pakistani population: a Pakistani database report. J Oncol, 1-8.
  16. Ferro, Roberto (2012). Pesticides and breast cancer. Adv Breast Cancer Res, 1, 30-35. https://doi.org/10.4236/abcr.2012.13005
  17. Gage M, Wattendorf D, Henry LR (2012). “Translational advances regarding hereditary breast cancer syndromes”. J Surg Oncol, 105, 444-51. https://doi.org/10.1002/jso.21856
  18. Gilani GM, Shahid S, Gilani AM (2006). Risk factors for breast cancer for women in Punjab, Pakistan: Results from a case-control study. Pak J Stat Oper Res, 2, 17-26.
  19. Gotzsche PC, Nielsen M (2011). Screening for breast cancer with mammography. Cochrane Database Syst Rev, 1, 1877
  20. Jamal S, Mamoon N, Mushtaq S, Luqman M (2006). Carcinoma of the male breast: a study of 141 cases from Northern Pakistan. Asian Pac J Cancer Prev, 7, 119-21.
  21. Hameed B, Jameela S, Shakeela D, et al (2012). Various aspects, patterns and risk factors in breast cancer patients of Balochistan. Asian Pac J Cancer Prev, 13, 4013-6. https://doi.org/10.7314/APJCP.2012.13.8.4013
  22. Hanif M, Zaidi P, Kamal S, Hameed A (2009). Institution-based cancer incidence in a local population in Pakistan: nine year data analysis. Asian Pac J Cancer Prev, 10, 227-30.
  23. Jahanzeb M (2008). Adjuvant trastuzumab therapy for HER2-positive breast cancer. Clin Breast Cancer, 8, 324-33. https://doi.org/10.3816/CBC.2008.n.037
  24. Jemal A, Bray F, Center MM, et al (2011). Global Cancer statistics. Ca Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  25. Kaiser J (2013). Cancer; Cholesterol forges link between obesity and breast cancer". Science, 342, 1028. https://doi.org/10.1126/science.342.6162.1028
  26. Khaliq S, Hameed A, Khaliq T, et al (2000). P53 mutations, polymorphisms and haplotypes in Pakistani ethnic groups and breast cancer patients. Genet Test, 4, 23-29. https://doi.org/10.1089/109065700316435
  27. Khoker S, Muhammad UQ, Masooma R, Naseem A, Afaf S (2012). Clinicopathologic profile of breast cancer patients in Pakistan: ten years data of a local cancer hospital. Asian Pac J Cancer Prev, 13, 693-8. https://doi.org/10.7314/APJCP.2012.13.2.693
  28. Lai FM, Chen P, Ku HC, et al (1996), A case-control study of Parity, Age at first full term pregnancy, breast-feeding and breast cancer in Taiwanese women. Proc Natl Science Council, ROC, part B: Life Sciences, 20, 71-7.
  29. Mahmood S, Rana TF, Ahmad M (2006). Common determinants of Ca Breast-a case control study in Lahore. Ann King Edward Med Coll, 12, 227-8.
  30. McPherson K, Steel C M, Dixon J M, (2000). Breast cancer; epidemiology, risk factors and genetics. Br Med J, 321, 624-8. https://doi.org/10.1136/bmj.321.7261.624
  31. Petit T, Dufour P, Tannock I (2011). “A critical evaluation of the role of aromatase inhibitors as adjuvant therapy for postmenopausal women with breast cancer”. Endocr Relat Cancer, 18, 79-89. https://doi.org/10.1530/ERC-10-0162
  32. Memon ZA, Shaikh AN, Rizwan S, Sardar MB (2013). Reasons for patient's delay in diagnosis of breast carcinoma in Pakistan. Asian Pac J Cancer Prev, 14, 7409-14 https://doi.org/10.7314/APJCP.2013.14.12.7409
  33. Moore MA, AriyaratneY, Badar F, et al (2009). Cancer epidemiology in South Asia past, present and future. Asian Pac J Cancer Prev, 10, 49-67.
  34. Naeem M, Khan N, Aman Z, et al (2008). Breast cancer: experience at lady reading hospital, Peshawar. J Ayub Med Coll, 20, 22-5.
  35. Rabia T, Sadia H, Marriam ZB, Fatima A (2013). Molecular stress or geography risk factors leading to high prevalence of Breast Cancer, J App Pharm, 4, 706-12.
  36. Rashid UM, Zaidi A, Torres D, et al (2006). Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients. Int J Cancer, 119, 2832-9. https://doi.org/10.1002/ijc.22269
  37. Reeder, JG; Vogel, VG (2008). "Breast cancer prevention" Cancer treatment and research, 141, 149-64. https://doi.org/10.1007/978-0-387-73161-2_10
  38. Sariego J (2010). “Breast cancer in the young patient”. The Amer surgeon, 76, 1397-401.
  39. Saslow D, Hannan J, Osuch J, et al (2004). “Clinical breast examination: practical recommendations for optimizing performance and reporting”. CA: A Cancer J Clini, 54, 327-44. https://doi.org/10.3322/canjclin.54.6.327
  40. Scavalieri E, Chakravarti D, Guttenplan J, et al. (2006). “Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention”. Biochimica et Biophysica Acta, 1766, 63-78
  41. Shamsi U, Khan S, Usman S, Soomro S, Azam I (2013). A Multicenter Matched Case Control Study of Breast Cancer Risk Factors among Women in Karachi, Pakistan. Asian Pac J Cancer Prev, 14, 183-8 https://doi.org/10.7314/APJCP.2013.14.1.183
  42. World Cancer Report (2008). International agency for research on Cancer. http://www.iarc.fr/en/publications/pdfs-online/ wcr/2008/wcr_2008.pdf. Retrieved 2011-02-26.
  43. Sohail S, Alam SN (2007). Breast cancer in Pakistan-awareness and early detection. J Col Phys Surg Pak, 17, 711-2.
  44. Talamini R, Franceschi S, La Vecchia C, et al (1996). The role of reproductive and menstrual factors in cancer of the breast before and after menopause, Europ J Cancer, 32, 303-10. https://doi.org/10.1016/0959-8049(95)00615-X
  45. Watson M (2008). “Assessment of suspected cancer”. InnoAiT, 1, 94-107.
  46. Yager JD (2006). Estrogen carcinogenesis in breast cancer. New Engl J Med, 354, 270-82. https://doi.org/10.1056/NEJMra050776
  47. Yousuf F and Jaffery NA (1985). On the incidence of malignant tumors of breast among females, Pakistan, Pak J Med Res, 24, 123-7.
  48. Yu YH, Liang C, Yuan XZ (2010). Diagnostic value of vacuum-assisted breast biopsy for breast carcinoma: a meta-analysis and systematic review. Breast Cancer Res Treat, 120, 469-79. https://doi.org/10.1007/s10549-010-0750-1
  49. Zahra F, Humayoun F, Yousaf T, Khan NA (2013).Evaluation of risk factors for carcinoma breast in Pakistani women. J Fatima Jinnah Med Assoc, 1, 34-8
  50. Zhu K, Caulfield J, Hunter S, et al (2005). Body mass index and breast cancer risk in African American women. Ann Epidemiol, 15, 123-8. https://doi.org/10.1016/j.annepidem.2004.05.011

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