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Genotype Distribution of Human Papillomavirus in Women with Abnormal Cervical Cytology in an Esophageal Carcinoma High Incidence Area of China

  • Mai, Rui-Qin (Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College) ;
  • Huang, Bo (Department of Pathology, Shantou University Medical College) ;
  • Shen, Ling (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Shantou University Medical College) ;
  • Zhang, Guo-Hong (Department of Pathology, Shantou University Medical College) ;
  • Hong, Liang-Li (Department of Pathology, the First Affiliated Hospital of Shantou University Medical College) ;
  • Cai, Ying-Mu (Department of Laboratory Medicine, the First Affiliated Hospital of Shantou University Medical College)
  • Published : 2014.06.30

Abstract

Infection with human papillomavirus (HPV) could affect genesis of both cervical and esophageal cancers. The type-specific distribution of HPV in cervical cytology abnormalities of women has remained unclear in Shantou, an esophageal cancer high-incidence area of China. Data from 22,617 women who were subjected to cervical HPV DNA testing with simultaneous cervical cytological examination during 2009-2013 were therefore here retrospectively evaluated in a hospital-based study. Overall, 16.2% (3,584/22,114)of women with normal cytology were HR-HPV positive, with HPV-52 (4.07%) as the most common type followed by -16 (3.63%), and -58 (2.46%). Prevalence of HR-HPV was 50.3% (253/503) in women with cervical cytological abnormalities, of which in ASC-H 71.4%, ASC-US 39.1%, HSIL 80.3% and LSIL 73.7%. HPV-58 (14.12%) was the most common type for all cervical cytological abnormalities, followed by HPV-16 (13.72%), and -52 (12.72%), while the more common HPV-16 type in ASC-H (42.9%) and HSIL (36.1%), HPV-52 and -58 were the most common types for ASC-US (10.3%) and LSIL (25%), respectively. Multiple HPV co-infections were identified in 33.2% (84/253) cytology abnormalities with positive HR-HPV, and the highest prevalence of HPV-58/16 combination in HSIL (28.6%, 6/21) was observed. Our data indicated a relative high prevalence of HPV-58 and -52 in women with cervical cytological abnormalities, which should be considered in the development of next-generation vaccines for Shantou.

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