DOI QR코드

DOI QR Code

Oncoplastic Breast Conserving Surgery with Nipple-areolar Preservation for Centrally Located Breast Cancer: a Retrospective Cohort Study

  • Ren, Zhao-Jun (Department of Pathology, Jiangsu Cancer Hospital) ;
  • Li, Xiu-Juan (Department of General Surgery, Jiangsu Cancer Hospital) ;
  • Xu, Xin-Yu (Department of Pathology, Jiangsu Cancer Hospital) ;
  • Xia, Lei (Department of Pathology, Jiangsu Cancer Hospital) ;
  • Tang, Jin-Hai (Department of General Surgery, Jiangsu Cancer Hospital)
  • Published : 2014.06.30

Abstract

A compariosn was made of survival outcomes of oncoplastic breast conserving therapy (oBCT) with nipple-areolar (NAC) preservation in women with centrally located breast cancer (CLBC) undergoing modified radical mastectomy (MRM) in China in a matched retrospective cohort study. We used a database including patients who received oBCT (n=91) or MRM (n=182) from 2003 to 2013 in our hospital. Matching was conducted according to five variables: age at diagnosis, axillary lymph node status, hormone receptor status, human epidermal growth factor-like receptor 2 status (HER-2) and tumor stage. The match ratio was 1:2. Median follow-up times for the oBCT and MRM groups were 83 and 81 months, respectively. There were no significant differences in 87-month overall, local, or distant recurrence-free survival between patients with oBCT and MRM (89%vs.90%; 93%vs.95%; 91%vs.92%;). For appropriate breast cancer patients, oBCT for CLBC is oncologically safe, oncoplastic techniques improving cosmetic outcomes.

References

  1. Veronesi U, Cascinelli N, Mariani L, et al (2002). Twentyyear follow-up of a randomized study comparing breastconserving surgery with radical mastectomy for early breast cancer. N Engl J Med, 347, 1227-32. https://doi.org/10.1056/NEJMoa020989
  2. Spear SL, Pelletiere CV, Wolfe AJ, et al (2003). Experience with reduction mammaplasty combined with breast conservation therapy in the treatment of breast cancer. Plast Reconstr Surg, 111, 1102-9. https://doi.org/10.1097/01.PRS.0000046491.87997.40
  3. Sun Meng-Qing. Meng Ai-Feng. Huang Xin-En. Wang Mei-Xiang (2013). Comparison of psychological influence on breast cancer patients between breast-conserving surgery and modified radical mastectomy. Asian Pac J Cancer Prev, 14, 149-52. https://doi.org/10.7314/APJCP.2013.14.1.149
  4. Van Dongen JA, Voogd AC, Fentiman IS, et al (2000). Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst, 92, 1143-50. https://doi.org/10.1093/jnci/92.14.1143
  5. Gerber B, Krause A, Reimer T, et al (2003). Skin-sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction is an oncologically safe procedure. Ann Surg, 238, 120-7.
  6. Dale PS, Giuliano AE (1996). Nipple-areolar preservation duringbreast-conserving therapy for subareolar breast carcinomas. Arch Surg, 131, 430-3. https://doi.org/10.1001/archsurg.1996.01430160088019
  7. Fisher B, Anderson S, Bryant J, et al (2002). Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med, 3471, 233-41.
  8. Fitzal F, Mittlboeck M, Trischler H, et al (2008). Breastconserving therapy for centrally located breast cancer. Ann Surg, 247, 470-6. https://doi.org/10.1097/SLA.0b013e31815b6991
  9. Jia WJ, Jia HX, Feng HY, et al (2014). HER2-enriched tumors have the highest risk of local recurrence in Chinese patients treated with breast conservation therapy. Asian Pac J Cancer Prev, 15, 315-20. https://doi.org/10.7314/APJCP.2014.15.1.315
  10. Parry RG, Cochran TC, Wolfort FG (1977). When is there nipple involvement in carcinoma of the breast? Plast Reconstr Surg, 59, 535-7. https://doi.org/10.1097/00006534-197759040-00010
  11. Poggi MM, Danforth DN, Sciuto LC, et al (2003). Eighteenyear results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial. Cancer, 98, 697-702. https://doi.org/10.1002/cncr.11580
  12. Rusby JE, Brachtel EF, Othus M, et al (2008). Development and validation of a model predictive of occult nipple involvement in women undergoing mastectomy. Br J Surg, 95, 1356-61. https://doi.org/10.1002/bjs.6349
  13. Simmons RM, Brennan MB, Christos P, Sckolnick M, Osborne M (2001). Recurrence rates in patients with central or retroareolar breast cancers treated with mastectomy or lumpectomy. Am J Surg, 182, 325-9. https://doi.org/10.1016/S0002-9610(01)00721-8
  14. Arriagada R, Le MG, Guinebretiere JM, et al (2003). Late local recurrences in a randomised trial comparing conservative treatment with total mastectomy in early breast cancer patients. Ann Oncol, 14, 1617-22. https://doi.org/10.1093/annonc/mdg452
  15. Blichert-Toft M, Nielsen M, During M, et al (2008). Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized dbcg-82TM protocol. Acta Oncol, 47, 672-81. https://doi.org/10.1080/02841860801971439
  16. Brachtel EF, Rusby JE, Michaelson JS, et al (2009). Occult nipple involvement in breast cancer: clinicopathologic findings in 316 consecutive mastectomy specimens. J Clin Oncol, 27, 4948-54. https://doi.org/10.1200/JCO.2008.20.8785

Cited by

  1. Cosmetic Outcomes and Quality of Life in Thai Women Post Breast Conserving Therapy for Breast Cancer vol.16, pp.11, 2015, https://doi.org/10.7314/APJCP.2015.16.11.4685