Asian Pacific Journal of Cancer Prevention
- Volume 15 Issue 12
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- Pages.4809-4813
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- 2014
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- 1513-7368(pISSN)
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- 2476-762X(eISSN)
DOI QR Code
Tumorigenic Effects of Endocrine-disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells
- Chu, Xiao Ting (Department of Animal Biotechnology, Hankyong National University) ;
- de la Cruz, Joseph (Department of Animal Life and Environmental Science, Hankyong National University) ;
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Hwang, Seong Gu
(Department of Animal Life and Environmental Science, Hankyong National University) ;
- Hong, Heeok (Department of Medical Science, School of Medicine, Konkuk University)
- Published : 2014.06.30
Abstract
Endocrine-disrupting chemicals (EDCs) have been reported to interfere with estrogen signaling. Exposure to these chemicals decreases the immune response and causes a wide range of diseases in animals and humans. Recently, many studies showed that licorice (Glycyrrhiza glabra) root extract (LRE) commonly called "gamcho" in Korea exhibits antioxidative, chemoprotective, and detoxifying properties. This study aimed to investigate the mechanism of action of LRE and to determine if and how LRE can alleviate the toxicity of EDCs. LRE was prepared by vacuum evaporation and freeze-drying after homogenization of licorice root powder that was soaked in 80% ethanol for 72 h. We used 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a representative EDC, which is known to induce tumors or cancers; MCF-7 breast cancer cells, used as a tumor model, were treated with TCDD and various concentrations of LRE (0, 50, 100, 200,
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References
- Abdel-Rahim M, Smith R, Safe S (2003). Aryl hydrocarbon receptor gene silencing with small inhibitory rna differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. Mol Pharmacol, 63, 1373-81. https://doi.org/10.1124/mol.63.6.1373
- Abdel-Rahman WM, Moustafa YM, Ahmed BO, Mostafa RM (2012). Endocrine disruptors and breast cancer risk - time to consider the environment. Asian Pac J Cancer Prev, 13, 5937-46. https://doi.org/10.7314/APJCP.2012.13.12.5937
- Androutsopoulos VP, Tsatsakis AM, Spandidos DA (2009). Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. BMC Cancer, 9, 187. https://doi.org/10.1186/1471-2407-9-187
- Beischlag TV, Morales JL, Hollingshead BD, Perdew GH (2008). The aryl hydrocarbon receptor complex and the control of gene expression. Toxicology, 268, 132-8.
- Bidgoli SA, Khorasani H, Keihan H, Sadeghipour A, Mehdizadeh A (2012). Role of endocrine disrupting chemicals in the occurrence of benign uterine leiomyomata: special emphasis on AhR tissue levels. Asian Pac J Cancer Prev, 11, 5445-50. https://doi.org/10.7314/APJCP.2012.13.11.5445
- Bidgoli SA, Korani M, Bozorgi N, et al (2011). Association between glycodelin and aryl hydrocarbon receptor in Iranian breast cancer patients: impact of environmental endocrine disrupting chemicals. Asian Pac J Cancer Prev, 12, 2431-5.
- Casalini P, Iorio MV, Berno V, et al (2007). Relationship between p53 and p27 expression following HER2 signaling. The Breast, 16, 597-605. https://doi.org/10.1016/j.breast.2007.05.007
- Cheel J, Antwerpen PV, Tumova L, et al (2010). Free radicalscavenging, antioxidant and immunostimulating effects of a licorice infusion (Glycyrrhiza glabra L). Food Chemistry, 122, 508-17. https://doi.org/10.1016/j.foodchem.2010.02.060
- Chen JX, Cheng MC, Li Y, Jiang CB (2011). Relationship between CYP1A1 genetic polymorphisms and renal cancer in China. Asian Pac J Cancer Prev, 12, 2163-6.
- Chen YJ, Hung CM, Kay N, et al (2012). Progesterone receptor is involved in 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-stimulated breast cancer cells proliferation. Cancer Letter, 319, 223-31. https://doi.org/10.1016/j.canlet.2012.01.017
- Craig WJ (1999). Health-promoting properties of common herbs. Am J Clin Nutr, 70, 491-9. https://doi.org/10.1093/ajcn/70.3.491s
- Cravedi JP, Zalko D, Savouret JF, et al (2007). The concept of endocrine disruption and human health. Med Sci, 23, 198-204.
- Fukai T, Satoh K, Nomura T, Sakagami H (2003). Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra. Fitoterapia, 74, 624-9. https://doi.org/10.1016/S0367-326X(03)00164-3
- Giordano A, Normanno N (2009). Breast cancer in the postgenomic era. Brit J Cancer, 103, 155.
- Hrabia A, Lesniak A, Sechman A (2013). In vitro effects of TCDD, PCB126 and PCB153 on estrogen receptors, caspases and metalloproteinase-2 mRNA expression in the chicken shell gland. Folia Biologica, 61, 277-82. https://doi.org/10.3409/fb61_3-4.277
- Hu X, Moscinski LC (2011). CDC2: a monopotent or pluripotent CDK? Cell Prolif, 44, 205-11. https://doi.org/10.1111/j.1365-2184.2011.00753.x
- Jablonska O, Piasecka J, Petroff BK, et al (2011). In vitro effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on ovarian, pituitary and pineal function in pigs. Theriogenology, 76, 921-32. https://doi.org/10.1016/j.theriogenology.2011.04.023
- Kamei J, Nakamura R, Ichiki H, Kubo M (2003). Anti-tussive principles of glycyrrhiza radix, a main component of the kampo preparations bakumondo-to (Mai-men-dong-tang). Eur J Pharmacol, 469, 159-63. https://doi.org/10.1016/S0014-2999(03)01728-X
- Kang JS, Yoon YD, Cho IJ, et al (2005). Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. J Pharmacol Exp Ther, 312, 1187-94.
- Kerdivel G, Habauzit D, Pakdel F (2013). Assessment and molecular actions of endocrine-disrupting chemicals that interfere with estrogen receptor pathways. Int J Endocrinol, 2013, 501851.
- Levine AJ (1997). p53, the cellular gatekeeper for growth and division. Cell, 88, 323-31. https://doi.org/10.1016/S0092-8674(00)81871-1
- Mimuraa J, Fujii-Kuriyama Y (2003). Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta, 1619, 263-8. https://doi.org/10.1016/S0304-4165(02)00485-3
- Pelekanou V, Leclercq G (2011). Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis. Int J Dev Biol, 55, 869-78. https://doi.org/10.1387/ijdb.113369vp
- Polyak K, Lee MH, Erdjument-Bromage H, et al (1994). Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 78, 59-66. https://doi.org/10.1016/0092-8674(94)90572-X
- Read AP, Strachan T (1999). Human molecular genetics 2. New York: Wiley; ISBN 0-471-33061-2. Chapter 18: cancer Genetics.
- Ryan KM, Phillips AC, Vousden KH (2001). Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol, 13, 332-7. https://doi.org/10.1016/S0955-0674(00)00216-7
- Shanle EK, Xu W (2011). Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action. Chem Res Toxicol, 24, 6-19. https://doi.org/10.1021/tx100231n
- Wahl GM, Carr AM (2001). The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol, 3, 277-86. https://doi.org/10.1038/ncb1201-e277
- Warner M, Eskenazi B, Mocarelli P, et al (2002). Serum dioxin concentrations and breast cancer risk in the seveso women's health study. Environ Health Perspect, 110, 625-8.
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