DOI QR코드

DOI QR Code

Survival Rate of Early Stage Endometrioid Adenocarcinoma of Endometrium Treated at Srinagarind Hospital

  • Krusun, Srichai (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Pesee, Montien (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Rasio, Withee (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Tangvoraphonkchai, Vorachai (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Supaadirek, Chunsri (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Thamronganatasakul, Komsan (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Supakalin, Narudom (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University) ;
  • Padoongcharoen, Prawat (Division of Radiotherapy, Department of Radiology, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University)
  • Published : 2014.03.01

Abstract

Purpose: To evaluate the survival outcome of early stage endometrioid adenocarcinoma of the endometrium with risk factors for locoregional recurrence treated with combined pelvic external beam radiotherapy (EBRT) and vaginal brachytherapy (VBT) after comprehensive surgery. Materials and Methods: Post-operative radiotherapy by pelvic EBRT and VBT for early stage endometrioid endometrial carcinoma resulted in excellent pelvic control with acceptable complications. This study showed no significant relationships between age, stage, histologic grade and LVSI and overall survival rate. Results: The 5-year overall survival rate (OS) of early stage endometrioid type of endometrial carcinoma was 85.7%. Acute toxicity occurred in 38.1% of the patients, all of whom were grade 1 or 2. Total late toxicity developed in 42.9% of study group, in which 36.99% of them were grade 1-2 and 4.76% were grade 3-4. Conclusions: Post-operative radiotherapy by pelvic EBRT and VBT is acceptable for early stage endometrioid endometrial carcinoma, independent of age, stage, histologic grade and LVSI.

References

  1. Aalders J, Abeler V, Kolstad P, et al (1980). Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathological study of 540 patients. Obstet Gynecol, 56, 419-27.
  2. Algan O, Tabesh T, Hanlon A, et al (1996). Improved outcome in patients treated with postoperative radiation therapy for pathologic stage I/II endometrial cancer. Int J Radiat Oncol Biol Phys, 35, 925-33.
  3. Bliss P, Cowie VJ (1992). Endometrial carcinoma: does the addition of intracavitary vault caesium to external beam therapy postoperatively result in improved control or increased morbidity? Clin Oncol, 4, 373-6. https://doi.org/10.1016/S0936-6555(05)81130-6
  4. Carey MS, O'Connell GJ, Johannson CR, et al (1995). Good outcome associated with a standardized treatment protocol using selective postoperative radiation in patients with clinical stage I adenocarcinoma of the endometrium. Gynecol Oncol, 57, 138-44. https://doi.org/10.1006/gyno.1995.1115
  5. Creasman WT (1997). Endometrial cancer: incidence, prognostic factors, diagnosis and treatment. Semin Oncol, 24, 140-50.
  6. Creutzberg CL, van Putten WL, Koper PC, et al (2000). Surgery and postoperative radiotherapy versus surgery alone for patients with stage-l endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet, 355,1404-11. https://doi.org/10.1016/S0140-6736(00)02139-5
  7. CTCAE (2009). US Department of health and human services. National Institutes of Health. NCI, 15, 1-194.
  8. FIGO (1988). Annual report on the results of treatment in gynecological cancer. Int J Gynecol Obstet, 28,189-3.
  9. Grigsby PW, Perez CA, Kuten A, et al (1992). Clinical stage I endometrial cancer: prognostic factors for local and distant metastasis and implication of the new FIGO surgical staging system. Int J Radiat Oncol BioI Phys, 22, 905-11. https://doi.org/10.1016/0360-3016(92)90786-H
  10. Hanprasertpong J, Sakolprakraikij S, Greater A (2008). Endometrial cancer in Thai women aged 45 years or younger. Asian Pac J Cancer Prev, 9, 58-62.
  11. Keys HM, Roberts JA, Brunetto VL, et al (2004). A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a gynecologic oncology group study. Gynecol Oncol, 92,744-51. https://doi.org/10.1016/j.ygyno.2003.11.048
  12. Khuhaprema T, Attasara P, Sriplung H, et al (2012). Cancer in Thailand 2004-2006, Ministry of public Health, Ministry of education, 6, 49-50.
  13. Kucera H, Vavra N, Weghaupt K (1990). Benefit of external irradiation in pathologic stage I endometrial carcinoma: a prospective clinical trial of 605 patients who received postoperative vaginal irradiation and additional pelvic irradiation in the presence of unfavorable prognostic factors. Gynecol Oncol, 38, 99-104. https://doi.org/10.1016/0090-8258(90)90018-G
  14. Manchana T, Khemapech N (2008). Endometrial adenocarcinoma in young Thai women. Asian Pac J Cancer Prev, 9, 283-6.
  15. Morrow CP, Bundy BN, Kurman RJ, et al (1991). Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a gynecologic oncology group study. Gynecol Oncol, 40, 55-6. https://doi.org/10.1016/0090-8258(91)90086-K
  16. Nori D, Merimsky O, Batata M, et al (1994). Postoperative high dose rate intravaginal brachytherapy combined with external irradiation for early stage endometrial cancer: a long-term follow-up. Int J Radiat Oncol BioI Phys, 309, 831-7.
  17. Nont RA, Smit VTHBM, Putter H, et al (2010). Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial. Lancet, 375, 816-23. https://doi.org/10.1016/S0140-6736(09)62163-2
  18. Rush S, Gal D, Potters L, et al (1995). Pelvic control following external beam radiation for surgical stage I endometrial adenocarcinoma. Int J Radiat Oncol BioI Phys, 33, 851-4. https://doi.org/10.1016/0360-3016(95)02012-8
  19. Podczaski E, Kaminski P, Gurski K, et al (1992). Detection and patterns of treatment failure in 300 consecutive cases of "early" endometrial cancer after primary surgery. Gynecol Oncol, 47, 323-7. https://doi.org/10.1016/0090-8258(92)90134-5
  20. Tangjitgamol S, Manusirivithaya S, Srijaipracharoen S, et al (2010). Endometrial cancer in Thai women: clinicopathological presentation and survival. Asian Pac J Cancer Prev, 11, 1267-72.
  21. Weiss E, Hirnle P, Arnole-Bofinger H, et al (1999). Therapeutic outcome and relation of acute and late side effects in the adjuvant radiotherapy of endometrial carcinoma stage I and II. Radiother Oncol, 53, 37-44. https://doi.org/10.1016/S0167-8140(99)00120-6
  22. Weiss MF, Connell PP, Waggoner S, et al (1999). External pelvic radiation therapy in stage IC endometrial carcinoma. Obstet Gynecol, 93, 599-602. https://doi.org/10.1016/S0029-7844(98)00479-7
  23. Wilairat W, Benjapibal M (2012). Presence of anemia and poor prognostic factors in patients with endometrial carcinoma. Asian Pac J Cancer Prev, 13,3187-90. https://doi.org/10.7314/APJCP.2012.13.7.3187

Cited by

  1. Accuracy of Intraoperative Gross Examination of Myometrial Invasion in Stage I-II Endometrial Cancer vol.15, pp.17, 2014, https://doi.org/10.7314/APJCP.2014.15.17.7061
  2. Accuracy of Sentinel Node in Detecting Lymph Node Metastasis in Primary Endometrial Carcinoma vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6691
  3. Relapse Patterns and Outcomes Following Recurrence of Endometrial Cancer in Northern Thai Women vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3861
  4. Oral Progestin Treatment for Early-Stage Endometrial Cancer vol.26, pp.6, 2016, https://doi.org/10.1097/IGC.0000000000000723