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Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis

  • Tang, Zhen-Hai (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Zhang, Chi (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Cheng, Pan (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Sun, Hong-Min (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Jin, Yu (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Chen, Yuan-Jing (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University) ;
  • Huang, Fen (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University)
  • Published : 2014.03.01

Abstract

The association between glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and risk of acute leukemia in Asians remains controversial. This study was therefore designed to evaluate the precise association in 23 studies identified by a search of PubMed and several other databases, up to December 2013. Using random or fixed effects models odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated. Heterogeneity across studies was assessed, and funnel plots were constructed to test for publication bias. The meta-analysis showed positive associations between GST polymorphisms (GSTM1 and GSTT1 but not GSTP1) and acute leukemia risk [(OR=1.47, 95% CI 1.18-1.83); (OR=1.32, 95% CI 1.07-1.62); (OR=1.01, 95% CI 0.84-1.23), respectively] and heterogeneity between the studies. The results suggested that the GSTM1 null genotype and GSTT1null genotype, but not the GSTP1 polymorphism, might be a potential risk factors for acute leukemia. Further well-designed studies are needed to confirm our findings.

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