- Volume 15 Issue 5
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Lobaplatin Combined Floxuridine/Pirarubicin-based Transcatheter Hepatic Arterial Chemoembolization for Unresectable Primary Hepatocellular Carcinoma
- Zhao, Chang (Department of Interventional Therapy, Affiliated Tumor Hospital of Guangxi Medical University) ;
- Wang, Xu-Jie (The Affiliated Hospital of Qingdao University) ;
- Wang, Song (The Affiliated Hospital of Qingdao University) ;
- Feng, Wei-Hua (The Affiliated Hospital of Qingdao University) ;
- Shi, Lei (The Affiliated Hospital of Qingdao University) ;
- Yu, Chun-Peng (The Affiliated Hospital of Qingdao University)
- Published : 2014.03.01
Purpose: To assess the effect and safety of lobaplatin combinated floxuridine /pirarubicin in transcatheter hepatic arterial chemoembolization(TACE) of unresectable primary liver cancer. Patients and Methods: TACE combined with the chemotherapy regimen was used to treat 34 unresectable primary liver cancer patients. DSA/MRI/CT/blood routine examinations were used to evaluate short term activity and toxicity after 4-5 weeks, the process being repeated if necessary. Results: Among the 34 cases, 1 (2.9%) showed a complete response, 21 (61.7%) a partial response, 8 (23.5%) stable disease, and 4 progressive disease, with a total effective rate of 67.6%. The content of alpha fetoprotein dropped by over 50% in 20 cases (58.8%). The rate of recovery was hepatalgia (88.2%), ascites (47.1%), appetite (55.9%), Performance Status(30.4%). The median follow-up time (MFT) was 281 days (63-558 days), and median progression-free survival was 118.5 days (95%, CI:88.8-148.2days). Adverse reactions (III-IV grade) were not common, with only 4 cases of vomiting and 2 cases of thrombocytopenia (III grade). Conclusions: Lobaplatin-based TACE is an effective and safe treatment for primary liver cancer.
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- A Randomized Controlled Trial Comparing Clinical Outcomes and Toxicity of Lobaplatin- Versus Cisplatin-Based Concurrent Chemotherapy Plus Radiotherapy and High-Dose-Rate Brachytherapy for FIGO Stage II and III Cervical Cancer vol.16, pp.14, 2015, https://doi.org/10.7314/APJCP.2015.16.14.5957
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- A randomized and open-label phase II trial reports the efficacy of neoadjuvant lobaplatin in breast cancer vol.9, pp.1, 2018, https://doi.org/10.1038/s41467-018-03210-2